Treatment Failure and Adverse Events After Amoxicillin-Clavulanate vs Amoxicillin for Pediatric Acute Sinusitis

IMPORTANCE: Acute sinusitis is one of the most common indications for antibiotic prescribing in children, with an estimated 4.9 million such prescriptions in the US annually. Consensus does not exist regarding the optimal empirical antibiotic. OBJECTIVE: To compare amoxicillin-clavulanate vs amoxici...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2023-09, Vol.330 (11), p.1064-1073
Hauptverfasser:	Savage, Timothy J, Kronman, Matthew P, Sreedhara, Sushama Kattinakere, Lee, Su Been, Oduol, Theresa, Huybrechts, Krista F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adolescent Adolescents Adverse events Amoxicillin Amoxicillin - adverse effects Amoxicillin - therapeutic use Amoxicillin-Potassium Clavulanate Combination - adverse effects Amoxicillin-Potassium Clavulanate Combination - therapeutic use Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - therapeutic use Antibiotics Child Child, Preschool Children Cohort Studies Emergency medical care Emergency medical services Failure Female Fungal infections Gastrointestinal symptoms Humans Hypersensitivity Infant Infant, Newborn Male Matching Mycoses - chemically induced Mycoses - etiology Original Investigation Patients Pediatrics Penicillin Risk Sinusitis Sinusitis - drug therapy Treatment Failure Yeast Yeasts
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