Dietary nutrient intake and cognitive function in the Age-Related Eye Disease Studies 1 and 2
The objective was to analyze associations between dietary intake of multiple nutrients and altered cognitive function and/or decline. Observational analyses of participants (n = 6334) in two randomized trials of nutritional supplements for age-related macular degeneration: Age-Related Eye Disease St...
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| Veröffentlicht in: | Alzheimer's & dementia 2023-10, Vol.19 (10), p.4311-4324 |
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| creator | Keenan, Tiarnan D L Agrón, Elvira Chew, Emily Y |
| description | The objective was to analyze associations between dietary intake of multiple nutrients and altered cognitive function and/or decline.
Observational analyses of participants (n = 6334) in two randomized trials of nutritional supplements for age-related macular degeneration: Age-Related Eye Disease Study (AREDS) and AREDS2.
In AREDS, for 4 of 38 nutrients examined, higher intake quintiles were significantly associated with decreased risk of cognitive impairment on the Modified Mini-Mental State test ( |
| doi_str_mv | 10.1002/alz.13033 |
| format | Article |
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Observational analyses of participants (n = 6334) in two randomized trials of nutritional supplements for age-related macular degeneration: Age-Related Eye Disease Study (AREDS) and AREDS2.
In AREDS, for 4 of 38 nutrients examined, higher intake quintiles were significantly associated with decreased risk of cognitive impairment on the Modified Mini-Mental State test (<80): β-carotene, copper, docosahexaenoic acid, and insoluble fiber. In AREDS2, for 13 of 44 nutrients, higher intake quintiles were associated with decreased risk on the Telephone Interview Cognitive Status-Modified (<30). Rate of cognitive decline over up to 10 years was not significantly different with higher intake of any nutrient.
Higher dietary intake of multiple nutrients, including specific vitamins, minerals, carotenoids, fatty acids, and fiber, was associated with lower risk of cognitive impairment but not slower decline in cognitive function.</description><identifier>ISSN: 1552-5260</identifier><identifier>ISSN: 1552-5279</identifier><identifier>EISSN: 1552-5279</identifier><identifier>DOI: 10.1002/alz.13033</identifier><identifier>PMID: 36939084</identifier><language>eng</language><publisher>United States</publisher><subject>Cognition ; Dietary Supplements ; Eating ; Humans ; Lutein ; Macular Degeneration - prevention & control ; Vitamins ; Zeaxanthins</subject><ispartof>Alzheimer's & dementia, 2023-10, Vol.19 (10), p.4311-4324</ispartof><rights>Published 2023. This article is a U.S. Government work and is in the public domain in the USA.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c341t-f91dbf4d1f004e69981620d3897c077c9817b41120065661200db089e37f585a3</citedby><cites>FETCH-LOGICAL-c341t-f91dbf4d1f004e69981620d3897c077c9817b41120065661200db089e37f585a3</cites><orcidid>0000-0002-2253-1772</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36939084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keenan, Tiarnan D L</creatorcontrib><creatorcontrib>Agrón, Elvira</creatorcontrib><creatorcontrib>Chew, Emily Y</creatorcontrib><creatorcontrib>AREDS and AREDS2 Research Groups</creatorcontrib><creatorcontrib>for the AREDS and AREDS2 Research Groups</creatorcontrib><title>Dietary nutrient intake and cognitive function in the Age-Related Eye Disease Studies 1 and 2</title><title>Alzheimer's & dementia</title><addtitle>Alzheimers Dement</addtitle><description>The objective was to analyze associations between dietary intake of multiple nutrients and altered cognitive function and/or decline.
Observational analyses of participants (n = 6334) in two randomized trials of nutritional supplements for age-related macular degeneration: Age-Related Eye Disease Study (AREDS) and AREDS2.
In AREDS, for 4 of 38 nutrients examined, higher intake quintiles were significantly associated with decreased risk of cognitive impairment on the Modified Mini-Mental State test (<80): β-carotene, copper, docosahexaenoic acid, and insoluble fiber. In AREDS2, for 13 of 44 nutrients, higher intake quintiles were associated with decreased risk on the Telephone Interview Cognitive Status-Modified (<30). Rate of cognitive decline over up to 10 years was not significantly different with higher intake of any nutrient.
Higher dietary intake of multiple nutrients, including specific vitamins, minerals, carotenoids, fatty acids, and fiber, was associated with lower risk of cognitive impairment but not slower decline in cognitive function.</description><subject>Cognition</subject><subject>Dietary Supplements</subject><subject>Eating</subject><subject>Humans</subject><subject>Lutein</subject><subject>Macular Degeneration - prevention & control</subject><subject>Vitamins</subject><subject>Zeaxanthins</subject><issn>1552-5260</issn><issn>1552-5279</issn><issn>1552-5279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUctOwzAQtBCIlseBH0A-wiGwjpM4PqGqLQ-pEhKPI7LcZNMaUqfETiX4ekwLFZxmVzs7u6Mh5ITBBQOIL3X9ecE4cL5D-ixN4yiNhdzd1hn0yIFzrwAJ5CzdJz2eSS4hT_rkZWTQ6_aD2s63Bq2nxnr9hlTbkhbNzBpvVkirzhbeNDZMqZ8jHcwwesBaeyzp-APpyDjUDumj70qDjrL1fnxE9ipdOzz-wUPyfD1-Gt5Gk_ubu-FgEhU8YT6qJCunVVKyKryImZQ5y2IoeS5FAUIUoRfThLEYIEuz7BvLKeQSuajSPNX8kFxtdJfddIFlEXy0ulbL1iyCN9Voo_5PrJmrWbNSDFKQPBZB4exHoW3eO3ReLYwrsK61xaZzKhZ5LmQmkiRQzzfUom2ca7Ha3mGgvvNQIQ-1ziNwT_8-tmX-BsC_ADxihO0</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Keenan, Tiarnan D L</creator><creator>Agrón, Elvira</creator><creator>Chew, Emily Y</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2253-1772</orcidid></search><sort><creationdate>20231001</creationdate><title>Dietary nutrient intake and cognitive function in the Age-Related Eye Disease Studies 1 and 2</title><author>Keenan, Tiarnan D L ; Agrón, Elvira ; Chew, Emily Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-f91dbf4d1f004e69981620d3897c077c9817b41120065661200db089e37f585a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cognition</topic><topic>Dietary Supplements</topic><topic>Eating</topic><topic>Humans</topic><topic>Lutein</topic><topic>Macular Degeneration - prevention & control</topic><topic>Vitamins</topic><topic>Zeaxanthins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keenan, Tiarnan D L</creatorcontrib><creatorcontrib>Agrón, Elvira</creatorcontrib><creatorcontrib>Chew, Emily Y</creatorcontrib><creatorcontrib>AREDS and AREDS2 Research Groups</creatorcontrib><creatorcontrib>for the AREDS and AREDS2 Research Groups</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Alzheimer's & dementia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keenan, Tiarnan D L</au><au>Agrón, Elvira</au><au>Chew, Emily Y</au><aucorp>AREDS and AREDS2 Research Groups</aucorp><aucorp>for the AREDS and AREDS2 Research Groups</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary nutrient intake and cognitive function in the Age-Related Eye Disease Studies 1 and 2</atitle><jtitle>Alzheimer's & dementia</jtitle><addtitle>Alzheimers Dement</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>19</volume><issue>10</issue><spage>4311</spage><epage>4324</epage><pages>4311-4324</pages><issn>1552-5260</issn><issn>1552-5279</issn><eissn>1552-5279</eissn><abstract>The objective was to analyze associations between dietary intake of multiple nutrients and altered cognitive function and/or decline.
Observational analyses of participants (n = 6334) in two randomized trials of nutritional supplements for age-related macular degeneration: Age-Related Eye Disease Study (AREDS) and AREDS2.
In AREDS, for 4 of 38 nutrients examined, higher intake quintiles were significantly associated with decreased risk of cognitive impairment on the Modified Mini-Mental State test (<80): β-carotene, copper, docosahexaenoic acid, and insoluble fiber. In AREDS2, for 13 of 44 nutrients, higher intake quintiles were associated with decreased risk on the Telephone Interview Cognitive Status-Modified (<30). Rate of cognitive decline over up to 10 years was not significantly different with higher intake of any nutrient.
Higher dietary intake of multiple nutrients, including specific vitamins, minerals, carotenoids, fatty acids, and fiber, was associated with lower risk of cognitive impairment but not slower decline in cognitive function.</abstract><cop>United States</cop><pmid>36939084</pmid><doi>10.1002/alz.13033</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-2253-1772</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1552-5260 |
| ispartof | Alzheimer's & dementia, 2023-10, Vol.19 (10), p.4311-4324 |
| issn | 1552-5260 1552-5279 1552-5279 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10509327 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Cognition Dietary Supplements Eating Humans Lutein Macular Degeneration - prevention & control Vitamins Zeaxanthins |
| title | Dietary nutrient intake and cognitive function in the Age-Related Eye Disease Studies 1 and 2 |
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