Universal redirection of CAR T cells against solid tumours via membrane-inserted ligands for the CAR

The effectiveness of chimaeric antigen receptor (CAR) T cell therapies for solid tumours is hindered by difficulties in the selection of an effective target antigen, owing to the heterogeneous expression of tumour antigens and to target antigen expression in healthy tissues. Here we show that T cell...

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Veröffentlicht in:	Nature biomedical engineering 2023-09, Vol.7 (9), p.1113-1128
Hauptverfasser:	Zhang, Angela Q., Hostetler, Alexander, Chen, Laura E., Mukkamala, Vainavi, Abraham, Wuhbet, Padilla, Lucia T., Wolff, Alexandra N., Maiorino, Laura, Backlund, Coralie M., Aung, Aereas, Melo, Mariane, Li, Na, Wu, Shengwei, Irvine, Darrell J.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/109 13/21 13/31 13/44 13/51 14 14/19 14/5 38 38/22 38/23 59 631/67/1059/2325 639/301/54/152 64 64/60 692/4028/67/1059/2325 Animals Antigen (tumor-associated) Antigens Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Cell membranes Cell proliferation Chimeric antigen receptors Fluorescein Fluorescein isothiocyanate Fluorescein-5-isothiocyanate - metabolism Humans Immunotherapy, Adoptive Inserts Ligands Lipids Lymphocytes Lymphocytes T Metastases Mice Neoplasms Priming Receptors Solid tumors T-Lymphocytes Tumors Xenotransplantation
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