Drug repositioning of anti-microbial agent nifuratel to treat mast cell-mediated allergic responses

Objectives: Our objective was to assess the effects and mechanisms of nifuratel on IgE-mediated mast cell (MC) degranulation and anaphylaxis in both in vitro and in vivo settings. Methods: The anti-allergic activity of nifuratel was evaluated in mast cell cultures and the passive cutaneous anaphylax...

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Veröffentlicht in:	International journal of immunopathology and pharmacology 2023-01, Vol.37, p.3946320231202349-3946320231202349
Hauptverfasser:	Lee, Ji Eon, Choi, Min Yeong, Min, Keun Young, Jo, Min Geun, Kim, Young Mi, Kim, Hyuk Soon, Choi, Wahn Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Allergies Anaphylaxis Antigens Cell activation Degranulation Drug development Immunoblotting Immunoglobulin E Immunoprecipitation Inflammation Kinases Mast cells Nifuratel Original Passive cutaneous anaphylaxis Phosphorylation Protein-tyrosine kinase Signal transduction Syk protein Tumor necrosis factor-α
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