Mechanism of a Dually Catalyzed Enantioselective Oxa-Pictet–Spengler Reaction and the Development of a Stereodivergent Variant

Enantioselective oxa-Pictet–Spengler reactions of tryptophol with aldehydes proceed under weakly acidic conditions utilizing a combination of two catalysts, an indoline HCl salt and a bisthiourea compound. Mechanistic investigations revealed the roles of both catalysts and confirmed the involvement...

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Veröffentlicht in:	ACS catalysis 2023-02, Vol.13 (4), p.2240-2249
Hauptverfasser:	Adili, Alafate, Webster, John-Paul, Zhao, Chenfei, Mallojjala, Sharath Chandra, Romero-Reyes, Moises A., Ghiviriga, Ion, Abboud, Khalil A., Vetticatt, Mathew J., Seidel, Daniel
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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