Clinicopathologic and Genomic Factors Impacting Efficacy of First-Line Chemoimmunotherapy in Advanced NSCLC

Although programmed cell death protein 1 and programmed death-ligand 1 (PD-L1) blockade in combination with platinum-doublet chemotherapy has become a mainstay of first-line treatment for advanced NSCLC, factors associated with efficacy of chemoimmunotherapy (CIT) are not well characterized. In this...

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Veröffentlicht in:	Journal of thoracic oncology 2023-06, Vol.18 (6), p.731-743
Hauptverfasser:	Alessi, Joao V., Elkrief, Arielle, Ricciuti, Biagio, Wang, Xinan, Cortellini, Alessio, Vaz, Victor R., Lamberti, Giuseppe, Frias, Rosa L., Venkatraman, Deepti, Fulgenzi, Claudia A.M., Pecci, Federica, Recondo, Gonzalo, Di Federico, Alessandro, Barrichello, Adriana, Park, Hyesun, Nishino, Mizuki, Hambelton, Grace M., Egger, Jacklynn V., Ladanyi, Marc, Digumarthy, Subba, Johnson, Bruce E., Christiani, David C., Lin, Xihong, Gainor, Justin F., Lin, Jessica J., Pinato, David J., Schoenfeld, Adam J., Awad, Mark M.
Format:	Artikel
Sprache:	eng
Schlagworte:	B7-H1 Antigen - metabolism Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Chemoimmunotherapy DNA Helicases - genetics First-line Genomics Humans Kelch-Like ECH-Associated Protein 1 - genetics KRAS Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Mutation NF-E2-Related Factor 2 - genetics NSCLC Nuclear Proteins - genetics PD-L1 expression Protein Serine-Threonine Kinases - genetics Proto-Oncogene Proteins p21(ras) - genetics Retrospective Studies Transcription Factors - genetics Tumor mutational burden
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