Fully human monoclonal antibody targeting activated ADAM10 on colorectal cancer cells

Metastasis and chemoresistance in colorectal cancer are mediated by certain poorly differentiated cancer cells, known as cancer stem cells, that are maintained by Notch downstream signaling initiated upon Notch cleavage by the metalloprotease ADAM10. It has been shown that ADAM10 overexpression corr...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2023-05, Vol.161, p.114494-114494, Article 114494
Hauptverfasser:	Saha, Nayanendu, Baek, Du-San, Mendoza, Rachelle P., Robev, Dorothea, Xu, Yan, Goldgur, Yehuda, De La Cruz, M. Jason, de Stanchina, Elisa, Janes, Peter W., Xu, Kai, Dimitrov, Dimiter S., Nikolov, Dimitar B.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM10 ADAM10 Protein - metabolism Amyloid Precursor Protein Secretases - metabolism Animals Antibodies, Monoclonal - pharmacology Chemotherapy COLO205 Colonic Neoplasms Colorectal cancer Colorectal Neoplasms - drug therapy Humans Male Membrane Proteins - metabolism Mice Monoclonal antibody Notch Xenograft
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