A Pyridyl-Furan Series Developed from the Open Global Health Library Block Red Blood Cell Invasion and Protein Trafficking in Plasmodium falciparum through Potential Inhibition of the Parasite’s PI4KIIIB Enzyme

With the resistance increasing to current antimalarial medicines, there is an urgent need to discover new drug targets and to develop new medicines against these targets. We therefore screened the Open Global Health Library of Merck KGaA, Darmstadt, Germany, of 250 compounds against the asexual bloo...

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Veröffentlicht in:	ACS infectious diseases 2023-09, Vol.9 (9), p.1695-1710
Hauptverfasser:	Ling, Dawson B., Nguyen, William, Looker, Oliver, Razook, Zahra, McCann, Kirsty, Barry, Alyssa E., Scheurer, Christian, Wittlin, Sergio, Famodimu, Mufuliat Toyin, Delves, Michael J, Bullen, Hayley E., Crabb, Brendan S., Sleebs, Brad E., Gilson, Paul R.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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