Protective potential of fish oil supplementation against insulin resistance and pancreatic islet damage in STZ-induced Wistar rats
Fish oil, which is regarded as the primary source of omega-3 fatty acids, has been long studied for its potential as an antidiabetic therapy. However, its protective ability against insulin resistance and pancreatic islet alteration remains unclear and controversial. To investigate the beneficial ef...
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Veröffentlicht in: | Open Veterinary Journal 2023-08, Vol.13 (8), p.983-990 |
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creator | Titisari, Nurina Fauzi, Ahmad Razak, Intan Shameha Abdul Samsulrizal, Nurdiana Ahmad, Hafandi |
description | Fish oil, which is regarded as the primary source of omega-3 fatty acids, has been long studied for its potential as an antidiabetic therapy. However, its protective ability against insulin resistance and pancreatic islet alteration remains unclear and controversial.
To investigate the beneficial effects of fish oil consumption on the progression of insulin resistance and pancreatic islet dysfunction in a rat model of diabetes.
Diabetic rats model (
= 30) were divided into five groups and received; 1) NS injection + NS oral (normal control); 2) NS injection + 3 g/kg fish oil (fish oil control); 3) streptozotocin (STZ) injection + NS oral [diabetes control (DC)]; 4) STZ injection + 1 g/kg fish oil (DFO1); and 5) STZ injection + 3 g/kg fish oil (DFO3). Fasting blood insulin was analyzed by commercial rat insulin enzyme-linked immunosorbent assay; meanwhile, the determination of insulin sensitivity was calculated by homeostatic model assessment of insulin resistance (HOMA-IR) and homeostatic model assessment of beta-cell function. A histological study was conducted on pancreas tissue using H and E staining.
Fish oil supplementation reduced hyperglycemia and ameliorated HOMA-IR in STZ-induced animal models indicating that fish oil supplementation improved insulin sensitivity. Furthermore, animals treated with fish oil at a dose of 3 g/kg (DFO3) showed an enhancement in pancreatic islets, which was displayed by less abnormal structures than DC animals. This could imply that the administration of fish oil, especially rich in bioactive omega-3 fatty acids effectively inhibits insulin resistance and restore islet of Langerhans alteration in rats injected with STZ.
Thus, the current study suggested that fish oil supplementation could support the treatment of diabetes but should not be considered as an alternative therapy. |
doi_str_mv | 10.5455/OVJ.2023.v13.i8.4 |
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To investigate the beneficial effects of fish oil consumption on the progression of insulin resistance and pancreatic islet dysfunction in a rat model of diabetes.
Diabetic rats model (
= 30) were divided into five groups and received; 1) NS injection + NS oral (normal control); 2) NS injection + 3 g/kg fish oil (fish oil control); 3) streptozotocin (STZ) injection + NS oral [diabetes control (DC)]; 4) STZ injection + 1 g/kg fish oil (DFO1); and 5) STZ injection + 3 g/kg fish oil (DFO3). Fasting blood insulin was analyzed by commercial rat insulin enzyme-linked immunosorbent assay; meanwhile, the determination of insulin sensitivity was calculated by homeostatic model assessment of insulin resistance (HOMA-IR) and homeostatic model assessment of beta-cell function. A histological study was conducted on pancreas tissue using H and E staining.
Fish oil supplementation reduced hyperglycemia and ameliorated HOMA-IR in STZ-induced animal models indicating that fish oil supplementation improved insulin sensitivity. Furthermore, animals treated with fish oil at a dose of 3 g/kg (DFO3) showed an enhancement in pancreatic islets, which was displayed by less abnormal structures than DC animals. This could imply that the administration of fish oil, especially rich in bioactive omega-3 fatty acids effectively inhibits insulin resistance and restore islet of Langerhans alteration in rats injected with STZ.
Thus, the current study suggested that fish oil supplementation could support the treatment of diabetes but should not be considered as an alternative therapy.</description><identifier>ISSN: 2226-4485</identifier><identifier>EISSN: 2218-6050</identifier><identifier>DOI: 10.5455/OVJ.2023.v13.i8.4</identifier><identifier>PMID: 37701670</identifier><language>eng</language><publisher>Libya: Faculty of Veterinary Medicine</publisher><subject>Animals ; diabetes mellitus ; Diabetes Mellitus, Experimental - chemically induced ; Dietary Supplements ; Fatty Acids, Omega-3 - pharmacology ; Fish Oils - pharmacology ; Insulin ; Insulin Resistance ; islet of langerhans ; Islets of Langerhans ; omega-3 fatty acid ; Original Research ; Rats ; Rats, Wistar ; Streptozocin ; wistar rats</subject><ispartof>Open Veterinary Journal, 2023-08, Vol.13 (8), p.983-990</ispartof><rights>2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495088/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495088/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37701670$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Titisari, Nurina</creatorcontrib><creatorcontrib>Fauzi, Ahmad</creatorcontrib><creatorcontrib>Razak, Intan Shameha Abdul</creatorcontrib><creatorcontrib>Samsulrizal, Nurdiana</creatorcontrib><creatorcontrib>Ahmad, Hafandi</creatorcontrib><title>Protective potential of fish oil supplementation against insulin resistance and pancreatic islet damage in STZ-induced Wistar rats</title><title>Open Veterinary Journal</title><addtitle>Open Vet J</addtitle><description>Fish oil, which is regarded as the primary source of omega-3 fatty acids, has been long studied for its potential as an antidiabetic therapy. However, its protective ability against insulin resistance and pancreatic islet alteration remains unclear and controversial.
To investigate the beneficial effects of fish oil consumption on the progression of insulin resistance and pancreatic islet dysfunction in a rat model of diabetes.
Diabetic rats model (
= 30) were divided into five groups and received; 1) NS injection + NS oral (normal control); 2) NS injection + 3 g/kg fish oil (fish oil control); 3) streptozotocin (STZ) injection + NS oral [diabetes control (DC)]; 4) STZ injection + 1 g/kg fish oil (DFO1); and 5) STZ injection + 3 g/kg fish oil (DFO3). Fasting blood insulin was analyzed by commercial rat insulin enzyme-linked immunosorbent assay; meanwhile, the determination of insulin sensitivity was calculated by homeostatic model assessment of insulin resistance (HOMA-IR) and homeostatic model assessment of beta-cell function. A histological study was conducted on pancreas tissue using H and E staining.
Fish oil supplementation reduced hyperglycemia and ameliorated HOMA-IR in STZ-induced animal models indicating that fish oil supplementation improved insulin sensitivity. Furthermore, animals treated with fish oil at a dose of 3 g/kg (DFO3) showed an enhancement in pancreatic islets, which was displayed by less abnormal structures than DC animals. This could imply that the administration of fish oil, especially rich in bioactive omega-3 fatty acids effectively inhibits insulin resistance and restore islet of Langerhans alteration in rats injected with STZ.
Thus, the current study suggested that fish oil supplementation could support the treatment of diabetes but should not be considered as an alternative therapy.</description><subject>Animals</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - chemically induced</subject><subject>Dietary Supplements</subject><subject>Fatty Acids, Omega-3 - pharmacology</subject><subject>Fish Oils - pharmacology</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>islet of langerhans</subject><subject>Islets of Langerhans</subject><subject>omega-3 fatty acid</subject><subject>Original Research</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Streptozocin</subject><subject>wistar rats</subject><issn>2226-4485</issn><issn>2218-6050</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNpVUk1v1DAUjBCIVkt_ABfkI5cEf8WxTwhVFIoqFYkCEhfrxX7ZusrGwU5W4sovx8uWivpgj_zmzRvZU1UvGW1a2bZvrr99ajjlotkz0QTdyCfVKedM14q29OkBc1VLqduT6iznO1pWxwQ37Hl1IrqOMtXR0-r35xQXdEvYI5kLmpYAI4kDGUK-JTGMJK_zPOKuVGAJcSKwhTDlhZRtHcNEEuaQF5gcEpg8mQtKWKiOhDziQjzsYIuFTr7c_KjD5FeHnnw_9CSSYMkvqmcDjBnP7s9N9fXi_c35x_rq-sPl-bur2kmml9oMhg_UKA--UxoFY7pXOKDv0PCOO9Yz1oJv0aABzoRQwiA6hoL2IJwWm-ryqOsj3Nk5hR2kXzZCsH8vYtpaSMX3iFYKRiVXvKeOS6cH7aSRHhigl13vsGi9PWrNa79D78rrJBgfiT6uTOHWbuPeFl3TUn1w8_peIcWfK-bF7kJ2OI4wYVyz5VpJxTquTKGyI9WlmHPC4WEOo_aQBVuyYA9ZsCULNujif1O9-t_gQ8e_nxd_AIQetD4</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Titisari, Nurina</creator><creator>Fauzi, Ahmad</creator><creator>Razak, Intan Shameha Abdul</creator><creator>Samsulrizal, Nurdiana</creator><creator>Ahmad, Hafandi</creator><general>Faculty of Veterinary Medicine</general><general>Tripoli University</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20230801</creationdate><title>Protective potential of fish oil supplementation against insulin resistance and pancreatic islet damage in STZ-induced Wistar rats</title><author>Titisari, Nurina ; Fauzi, Ahmad ; Razak, Intan Shameha Abdul ; Samsulrizal, Nurdiana ; Ahmad, Hafandi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-9f92f096dad768e3118b6efed7e9272c1b115ad5e9e9a2133639eec1e30ba3c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - chemically induced</topic><topic>Dietary Supplements</topic><topic>Fatty Acids, Omega-3 - pharmacology</topic><topic>Fish Oils - pharmacology</topic><topic>Insulin</topic><topic>Insulin Resistance</topic><topic>islet of langerhans</topic><topic>Islets of Langerhans</topic><topic>omega-3 fatty acid</topic><topic>Original Research</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Streptozocin</topic><topic>wistar rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Titisari, Nurina</creatorcontrib><creatorcontrib>Fauzi, Ahmad</creatorcontrib><creatorcontrib>Razak, Intan Shameha Abdul</creatorcontrib><creatorcontrib>Samsulrizal, Nurdiana</creatorcontrib><creatorcontrib>Ahmad, Hafandi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Open Veterinary Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Titisari, Nurina</au><au>Fauzi, Ahmad</au><au>Razak, Intan Shameha Abdul</au><au>Samsulrizal, Nurdiana</au><au>Ahmad, Hafandi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective potential of fish oil supplementation against insulin resistance and pancreatic islet damage in STZ-induced Wistar rats</atitle><jtitle>Open Veterinary Journal</jtitle><addtitle>Open Vet J</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>13</volume><issue>8</issue><spage>983</spage><epage>990</epage><pages>983-990</pages><issn>2226-4485</issn><eissn>2218-6050</eissn><abstract>Fish oil, which is regarded as the primary source of omega-3 fatty acids, has been long studied for its potential as an antidiabetic therapy. However, its protective ability against insulin resistance and pancreatic islet alteration remains unclear and controversial.
To investigate the beneficial effects of fish oil consumption on the progression of insulin resistance and pancreatic islet dysfunction in a rat model of diabetes.
Diabetic rats model (
= 30) were divided into five groups and received; 1) NS injection + NS oral (normal control); 2) NS injection + 3 g/kg fish oil (fish oil control); 3) streptozotocin (STZ) injection + NS oral [diabetes control (DC)]; 4) STZ injection + 1 g/kg fish oil (DFO1); and 5) STZ injection + 3 g/kg fish oil (DFO3). Fasting blood insulin was analyzed by commercial rat insulin enzyme-linked immunosorbent assay; meanwhile, the determination of insulin sensitivity was calculated by homeostatic model assessment of insulin resistance (HOMA-IR) and homeostatic model assessment of beta-cell function. A histological study was conducted on pancreas tissue using H and E staining.
Fish oil supplementation reduced hyperglycemia and ameliorated HOMA-IR in STZ-induced animal models indicating that fish oil supplementation improved insulin sensitivity. Furthermore, animals treated with fish oil at a dose of 3 g/kg (DFO3) showed an enhancement in pancreatic islets, which was displayed by less abnormal structures than DC animals. This could imply that the administration of fish oil, especially rich in bioactive omega-3 fatty acids effectively inhibits insulin resistance and restore islet of Langerhans alteration in rats injected with STZ.
Thus, the current study suggested that fish oil supplementation could support the treatment of diabetes but should not be considered as an alternative therapy.</abstract><cop>Libya</cop><pub>Faculty of Veterinary Medicine</pub><pmid>37701670</pmid><doi>10.5455/OVJ.2023.v13.i8.4</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals diabetes mellitus Diabetes Mellitus, Experimental - chemically induced Dietary Supplements Fatty Acids, Omega-3 - pharmacology Fish Oils - pharmacology Insulin Insulin Resistance islet of langerhans Islets of Langerhans omega-3 fatty acid Original Research Rats Rats, Wistar Streptozocin wistar rats |
title | Protective potential of fish oil supplementation against insulin resistance and pancreatic islet damage in STZ-induced Wistar rats |
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