Macrophages immunomodulation induced by Porphyromonas gingivalis and oral antimicrobial peptides
[Abstract] Porphyromonas gingivalis is a keystone pathogen associated with periodontitis development, a chronic inflammatory pathology characterized by the destruction of the supporting teeth structure. Macrophages are recruited cells in the inflammatory infiltrate from patients with periodontitis....
Gespeichert in:
| Veröffentlicht in: | Odontology 2023-10, Vol.111 (4), p.778-792 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 792 |
|---|---|
| container_issue | 4 |
| container_start_page | 778 |
| container_title | Odontology |
| container_volume | 111 |
| creator | Blanca Esther Blancas-Luciano Jaime Zamora-Chimal Pablo Gomes da Silva-de Rosenzweig Mariana Ramos-Mares Ana Maria Fernandez-Presas |
| description | [Abstract] Porphyromonas gingivalis is a keystone pathogen associated with periodontitis development, a chronic inflammatory pathology characterized by the destruction of the supporting teeth structure. Macrophages are recruited cells in the inflammatory infiltrate from patients with periodontitis. They are activated by the P. gingivalis virulence factors arsenal, promoting an inflammatory microenvironment characterized by cytokine production (TNF-α, IL-1β, IL-6), prostaglandins, and metalloproteinases (MMPs) that foster the tissular destruction characteristic of periodontitis. Furthermore, P. gingivalis suppresses the generation of nitric oxide, a potent antimicrobial molecule, through its degradation, and incorporating its byproducts as a source of energy. Oral antimicrobial peptides can contribute to controlling the disease due to their antimicrobial and immunoregulatory activity, which allows them to maintain homeostasis in the oral cavity. This study aimed to analyze the immunopathological role of macrophages activated by P. gingivalis in periodontitis and suggested using antimicrobial peptides as therapeutic agents to treat the disease. |
| doi_str_mv | 10.1007/s10266-023-00798-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10492884</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2863036100</sourcerecordid><originalsourceid>FETCH-LOGICAL-c539t-c6e0df19804f5fe6cb1a50969bdb62db8b57c93f5ad9d03f77a1894891c89ac93</originalsourceid><addsrcrecordid>eNp9Ustu1TAQjRAVrdr-AAsUiQ2bgF_xY4VQBQWpCBawNo7t5BoldrCTVvfvO23KLbBgY3t0Hp7xcVU9x-g1Rki8KRgRzhtEaAOlks3Nk-oEcywbTNr26eHMxHF1XkroECMYI4HbZ9Ux5VIJxvBJ9eOzsTnNOzP4UodpWmOakltHs4QU6xDdar2ru339NeV5t8-ARlPqIcQhXJsxlNpEV6dsRjgsYQrg1gWoZj8vwflyVh31Ziz-_GE_rb5_eP_t4mNz9eXy08W7q8a2VC2N5R65HiuJWN_2ntsOmxYprjrXceI62bXCKtq3ximHaC-EwVIxqbCVygByWr3dfOe1m7yzPi7QlJ5zmEze62SC_huJYaeHdK0xYopIycDh1YNDTr9WXxY9hWL9OJro01o0EZIj1SqMgPryH-rPtOYI82kiOUWUQ0bAIhsL3qSU7PtDNxjpuxD1FqKGEPV9iPoGRC_-nOMg-R0ZEOhGKADFwefHu_9re7mpwDNYM6Y4hugfpXbAyaW4aHKvwvBVGIiJRkJIWBRhRAiuKL0FmBHBeQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2863036100</pqid></control><display><type>article</type><title>Macrophages immunomodulation induced by Porphyromonas gingivalis and oral antimicrobial peptides</title><source>SpringerLink Journals - AutoHoldings</source><creator>Blanca Esther Blancas-Luciano ; Jaime Zamora-Chimal ; Pablo Gomes da Silva-de Rosenzweig ; Mariana Ramos-Mares ; Ana Maria Fernandez-Presas</creator><creatorcontrib>Blanca Esther Blancas-Luciano ; Jaime Zamora-Chimal ; Pablo Gomes da Silva-de Rosenzweig ; Mariana Ramos-Mares ; Ana Maria Fernandez-Presas ; Facultad de Medicina ; Unidad de Posgrado ; Departamento de Microbiologia y Parasitologia ; Unidad de Investigacion en Medicina Experimental ; Ciudad Universitaria ; Universidad Nacional Autonoma de Mexico ; FCS ; Hospital General de Mexico ; Col. Universidad Nacional Autonoma de Mexico ; Centro de Investigacion en Ciencias de la Salud (CICSA ; Universidad Anahuac Mexico Campus Norte ; Posgrado en Ciencias Biologicas</creatorcontrib><description>[Abstract] Porphyromonas gingivalis is a keystone pathogen associated with periodontitis development, a chronic inflammatory pathology characterized by the destruction of the supporting teeth structure. Macrophages are recruited cells in the inflammatory infiltrate from patients with periodontitis. They are activated by the P. gingivalis virulence factors arsenal, promoting an inflammatory microenvironment characterized by cytokine production (TNF-α, IL-1β, IL-6), prostaglandins, and metalloproteinases (MMPs) that foster the tissular destruction characteristic of periodontitis. Furthermore, P. gingivalis suppresses the generation of nitric oxide, a potent antimicrobial molecule, through its degradation, and incorporating its byproducts as a source of energy. Oral antimicrobial peptides can contribute to controlling the disease due to their antimicrobial and immunoregulatory activity, which allows them to maintain homeostasis in the oral cavity. This study aimed to analyze the immunopathological role of macrophages activated by P. gingivalis in periodontitis and suggested using antimicrobial peptides as therapeutic agents to treat the disease.</description><identifier>ISSN: 1618-1247</identifier><identifier>EISSN: 1618-1255</identifier><identifier>DOI: 10.1007/s10266-023-00798-w</identifier><identifier>PMID: 36897441</identifier><language>eng</language><publisher>Singapore: The Society of the Nippon Dental University</publisher><subject>Antimicrobial peptides ; Dentistry ; Gum disease ; Homeostasis ; Immunomodulation ; Immunoregulation ; Inflammation ; Macrophages ; Medicine ; Nitric oxide ; Oral and Maxillofacial Surgery ; Oral cavity ; Periodontitis ; Porphyromonas gingivalis ; Prostaglandins ; Review ; Review Article ; Tumor necrosis factor-α ; Virulence factors</subject><ispartof>Odontology, 2023-10, Vol.111 (4), p.778-792</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-c6e0df19804f5fe6cb1a50969bdb62db8b57c93f5ad9d03f77a1894891c89ac93</citedby><cites>FETCH-LOGICAL-c539t-c6e0df19804f5fe6cb1a50969bdb62db8b57c93f5ad9d03f77a1894891c89ac93</cites><orcidid>0000-0003-3690-0775 ; 0000-0002-6985-1378 ; 0000-0001-8180-7276</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10266-023-00798-w$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10266-023-00798-w$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36897441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blanca Esther Blancas-Luciano</creatorcontrib><creatorcontrib>Jaime Zamora-Chimal</creatorcontrib><creatorcontrib>Pablo Gomes da Silva-de Rosenzweig</creatorcontrib><creatorcontrib>Mariana Ramos-Mares</creatorcontrib><creatorcontrib>Ana Maria Fernandez-Presas</creatorcontrib><creatorcontrib>Facultad de Medicina</creatorcontrib><creatorcontrib>Unidad de Posgrado</creatorcontrib><creatorcontrib>Departamento de Microbiologia y Parasitologia</creatorcontrib><creatorcontrib>Unidad de Investigacion en Medicina Experimental</creatorcontrib><creatorcontrib>Ciudad Universitaria</creatorcontrib><creatorcontrib>Universidad Nacional Autonoma de Mexico</creatorcontrib><creatorcontrib>FCS</creatorcontrib><creatorcontrib>Hospital General de Mexico</creatorcontrib><creatorcontrib>Col. Universidad Nacional Autonoma de Mexico</creatorcontrib><creatorcontrib>Centro de Investigacion en Ciencias de la Salud (CICSA</creatorcontrib><creatorcontrib>Universidad Anahuac Mexico Campus Norte</creatorcontrib><creatorcontrib>Posgrado en Ciencias Biologicas</creatorcontrib><title>Macrophages immunomodulation induced by Porphyromonas gingivalis and oral antimicrobial peptides</title><title>Odontology</title><addtitle>Odontology</addtitle><addtitle>Odontology</addtitle><description>[Abstract] Porphyromonas gingivalis is a keystone pathogen associated with periodontitis development, a chronic inflammatory pathology characterized by the destruction of the supporting teeth structure. Macrophages are recruited cells in the inflammatory infiltrate from patients with periodontitis. They are activated by the P. gingivalis virulence factors arsenal, promoting an inflammatory microenvironment characterized by cytokine production (TNF-α, IL-1β, IL-6), prostaglandins, and metalloproteinases (MMPs) that foster the tissular destruction characteristic of periodontitis. Furthermore, P. gingivalis suppresses the generation of nitric oxide, a potent antimicrobial molecule, through its degradation, and incorporating its byproducts as a source of energy. Oral antimicrobial peptides can contribute to controlling the disease due to their antimicrobial and immunoregulatory activity, which allows them to maintain homeostasis in the oral cavity. This study aimed to analyze the immunopathological role of macrophages activated by P. gingivalis in periodontitis and suggested using antimicrobial peptides as therapeutic agents to treat the disease.</description><subject>Antimicrobial peptides</subject><subject>Dentistry</subject><subject>Gum disease</subject><subject>Homeostasis</subject><subject>Immunomodulation</subject><subject>Immunoregulation</subject><subject>Inflammation</subject><subject>Macrophages</subject><subject>Medicine</subject><subject>Nitric oxide</subject><subject>Oral and Maxillofacial Surgery</subject><subject>Oral cavity</subject><subject>Periodontitis</subject><subject>Porphyromonas gingivalis</subject><subject>Prostaglandins</subject><subject>Review</subject><subject>Review Article</subject><subject>Tumor necrosis factor-α</subject><subject>Virulence factors</subject><issn>1618-1247</issn><issn>1618-1255</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9Ustu1TAQjRAVrdr-AAsUiQ2bgF_xY4VQBQWpCBawNo7t5BoldrCTVvfvO23KLbBgY3t0Hp7xcVU9x-g1Rki8KRgRzhtEaAOlks3Nk-oEcywbTNr26eHMxHF1XkroECMYI4HbZ9Ux5VIJxvBJ9eOzsTnNOzP4UodpWmOakltHs4QU6xDdar2ru339NeV5t8-ARlPqIcQhXJsxlNpEV6dsRjgsYQrg1gWoZj8vwflyVh31Ziz-_GE_rb5_eP_t4mNz9eXy08W7q8a2VC2N5R65HiuJWN_2ntsOmxYprjrXceI62bXCKtq3ximHaC-EwVIxqbCVygByWr3dfOe1m7yzPi7QlJ5zmEze62SC_huJYaeHdK0xYopIycDh1YNDTr9WXxY9hWL9OJro01o0EZIj1SqMgPryH-rPtOYI82kiOUWUQ0bAIhsL3qSU7PtDNxjpuxD1FqKGEPV9iPoGRC_-nOMg-R0ZEOhGKADFwefHu_9re7mpwDNYM6Y4hugfpXbAyaW4aHKvwvBVGIiJRkJIWBRhRAiuKL0FmBHBeQ</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Blanca Esther Blancas-Luciano</creator><creator>Jaime Zamora-Chimal</creator><creator>Pablo Gomes da Silva-de Rosenzweig</creator><creator>Mariana Ramos-Mares</creator><creator>Ana Maria Fernandez-Presas</creator><general>The Society of the Nippon Dental University</general><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3690-0775</orcidid><orcidid>https://orcid.org/0000-0002-6985-1378</orcidid><orcidid>https://orcid.org/0000-0001-8180-7276</orcidid></search><sort><creationdate>20231001</creationdate><title>Macrophages immunomodulation induced by Porphyromonas gingivalis and oral antimicrobial peptides</title><author>Blanca Esther Blancas-Luciano ; Jaime Zamora-Chimal ; Pablo Gomes da Silva-de Rosenzweig ; Mariana Ramos-Mares ; Ana Maria Fernandez-Presas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-c6e0df19804f5fe6cb1a50969bdb62db8b57c93f5ad9d03f77a1894891c89ac93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antimicrobial peptides</topic><topic>Dentistry</topic><topic>Gum disease</topic><topic>Homeostasis</topic><topic>Immunomodulation</topic><topic>Immunoregulation</topic><topic>Inflammation</topic><topic>Macrophages</topic><topic>Medicine</topic><topic>Nitric oxide</topic><topic>Oral and Maxillofacial Surgery</topic><topic>Oral cavity</topic><topic>Periodontitis</topic><topic>Porphyromonas gingivalis</topic><topic>Prostaglandins</topic><topic>Review</topic><topic>Review Article</topic><topic>Tumor necrosis factor-α</topic><topic>Virulence factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blanca Esther Blancas-Luciano</creatorcontrib><creatorcontrib>Jaime Zamora-Chimal</creatorcontrib><creatorcontrib>Pablo Gomes da Silva-de Rosenzweig</creatorcontrib><creatorcontrib>Mariana Ramos-Mares</creatorcontrib><creatorcontrib>Ana Maria Fernandez-Presas</creatorcontrib><creatorcontrib>Facultad de Medicina</creatorcontrib><creatorcontrib>Unidad de Posgrado</creatorcontrib><creatorcontrib>Departamento de Microbiologia y Parasitologia</creatorcontrib><creatorcontrib>Unidad de Investigacion en Medicina Experimental</creatorcontrib><creatorcontrib>Ciudad Universitaria</creatorcontrib><creatorcontrib>Universidad Nacional Autonoma de Mexico</creatorcontrib><creatorcontrib>FCS</creatorcontrib><creatorcontrib>Hospital General de Mexico</creatorcontrib><creatorcontrib>Col. Universidad Nacional Autonoma de Mexico</creatorcontrib><creatorcontrib>Centro de Investigacion en Ciencias de la Salud (CICSA</creatorcontrib><creatorcontrib>Universidad Anahuac Mexico Campus Norte</creatorcontrib><creatorcontrib>Posgrado en Ciencias Biologicas</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Odontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blanca Esther Blancas-Luciano</au><au>Jaime Zamora-Chimal</au><au>Pablo Gomes da Silva-de Rosenzweig</au><au>Mariana Ramos-Mares</au><au>Ana Maria Fernandez-Presas</au><aucorp>Facultad de Medicina</aucorp><aucorp>Unidad de Posgrado</aucorp><aucorp>Departamento de Microbiologia y Parasitologia</aucorp><aucorp>Unidad de Investigacion en Medicina Experimental</aucorp><aucorp>Ciudad Universitaria</aucorp><aucorp>Universidad Nacional Autonoma de Mexico</aucorp><aucorp>FCS</aucorp><aucorp>Hospital General de Mexico</aucorp><aucorp>Col. Universidad Nacional Autonoma de Mexico</aucorp><aucorp>Centro de Investigacion en Ciencias de la Salud (CICSA</aucorp><aucorp>Universidad Anahuac Mexico Campus Norte</aucorp><aucorp>Posgrado en Ciencias Biologicas</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Macrophages immunomodulation induced by Porphyromonas gingivalis and oral antimicrobial peptides</atitle><jtitle>Odontology</jtitle><stitle>Odontology</stitle><addtitle>Odontology</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>111</volume><issue>4</issue><spage>778</spage><epage>792</epage><pages>778-792</pages><issn>1618-1247</issn><eissn>1618-1255</eissn><abstract>[Abstract] Porphyromonas gingivalis is a keystone pathogen associated with periodontitis development, a chronic inflammatory pathology characterized by the destruction of the supporting teeth structure. Macrophages are recruited cells in the inflammatory infiltrate from patients with periodontitis. They are activated by the P. gingivalis virulence factors arsenal, promoting an inflammatory microenvironment characterized by cytokine production (TNF-α, IL-1β, IL-6), prostaglandins, and metalloproteinases (MMPs) that foster the tissular destruction characteristic of periodontitis. Furthermore, P. gingivalis suppresses the generation of nitric oxide, a potent antimicrobial molecule, through its degradation, and incorporating its byproducts as a source of energy. Oral antimicrobial peptides can contribute to controlling the disease due to their antimicrobial and immunoregulatory activity, which allows them to maintain homeostasis in the oral cavity. This study aimed to analyze the immunopathological role of macrophages activated by P. gingivalis in periodontitis and suggested using antimicrobial peptides as therapeutic agents to treat the disease.</abstract><cop>Singapore</cop><pub>The Society of the Nippon Dental University</pub><pmid>36897441</pmid><doi>10.1007/s10266-023-00798-w</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0003-3690-0775</orcidid><orcidid>https://orcid.org/0000-0002-6985-1378</orcidid><orcidid>https://orcid.org/0000-0001-8180-7276</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1618-1247 |
| ispartof | Odontology, 2023-10, Vol.111 (4), p.778-792 |
| issn | 1618-1247 1618-1255 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10492884 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Antimicrobial peptides Dentistry Gum disease Homeostasis Immunomodulation Immunoregulation Inflammation Macrophages Medicine Nitric oxide Oral and Maxillofacial Surgery Oral cavity Periodontitis Porphyromonas gingivalis Prostaglandins Review Review Article Tumor necrosis factor-α Virulence factors |
| title | Macrophages immunomodulation induced by Porphyromonas gingivalis and oral antimicrobial peptides |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T08%3A11%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Macrophages%20immunomodulation%20induced%20by%20Porphyromonas%20gingivalis%20and%20oral%20antimicrobial%20peptides&rft.jtitle=Odontology&rft.au=Blanca%20Esther%20Blancas-Luciano&rft.aucorp=Facultad%20de%20Medicina&rft.date=2023-10-01&rft.volume=111&rft.issue=4&rft.spage=778&rft.epage=792&rft.pages=778-792&rft.issn=1618-1247&rft.eissn=1618-1255&rft_id=info:doi/10.1007/s10266-023-00798-w&rft_dat=%3Cproquest_pubme%3E2863036100%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2863036100&rft_id=info:pmid/36897441&rfr_iscdi=true |