Towards an adiposity-related disease framework for the diagnosis and management of obesities

Obesity is a complex disease that relapses frequently and associates with multiple complications that comprise a worldwide health priority because of its rising prevalence and association with numerous complications, including metabolic disorders, mechanic pathologies, and cancer, among others. Note...

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Veröffentlicht in:Reviews in endocrine & metabolic disorders 2023-10, Vol.24 (5), p.795-807
Hauptverfasser: Perdomo, Carolina M., Avilés-Olmos, Icíar, Dicker, Dror, Frühbeck, Gema
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container_title Reviews in endocrine & metabolic disorders
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creator Perdomo, Carolina M.
Avilés-Olmos, Icíar
Dicker, Dror
Frühbeck, Gema
description Obesity is a complex disease that relapses frequently and associates with multiple complications that comprise a worldwide health priority because of its rising prevalence and association with numerous complications, including metabolic disorders, mechanic pathologies, and cancer, among others. Noteworthy, excess adiposity is accompanied by chronic inflammation, oxidative stress, insulin resistance, and subsequent organ dysfunction. This dysfunctional adipose tissue is initially stored in the visceral depot, overflowing subsequently to produce lipotoxicity in ectopic depots like liver, heart, muscle, and pancreas, among others. People living with obesity need a diagnostic approach that considers an exhaustive pathophysiology and complications assessment. Thus, it is essential to warrant a holistic diagnosis and management that guarantees an adequate health status, and quality of life. The present review summarizes the different complications associated with obesity, at the same time, we aim to fostering a novel framework that enhances a patient-centered approach to obesity management in the precision medicine era.
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subjects Adipose tissue
Adipose tissues
Cardiac muscle
Care and treatment
Development and progression
Diabetes
Diagnosis
Endocrinology
Inflammation
Insulin resistance
Internal Medicine
Liver
Medicine
Medicine & Public Health
Metabolic disorders
Obesity
Oxidative stress
Precision medicine
Quality of life
Type 2 diabetes
Weight control
title Towards an adiposity-related disease framework for the diagnosis and management of obesities
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