Evaluation of drug carrier hepatotoxicity using primary cell culture models

This study aims to establish a primary rat hepatocyte culture model to evaluate dose-dependent hepatotoxic effects of drug carriers (lipopolymer nanoparticles; LPNs) temporal. Primary rat hepatocyte cell cultures were used to determine half-maximal Inhibition Concentrations (IC50) of the drug-carrie...

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Veröffentlicht in:	Nanomedicine 2023-02, Vol.48, p.102651-102651, Article 102651
Hauptverfasser:	Kibar, Güneş, Dutta, Subhadeep, Rege, Kaushal, Usta, O. Berk
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumins Animals Cells, Cultured Chemical and Drug Induced Liver Injury - metabolism Drug Carriers - pharmacology Hepatocytes Hepatotoxicity In vitro culture Lipopolymer nanoparticle (LPN) Nanotoxicity Primary Cell Culture Primary rat hepatocyte Rats Urea - metabolism Urea - pharmacology
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