Inhibition of complement C3 signaling ameliorates locomotor and visual dysfunction in autoimmune inflammatory diseases

Neuromyelitis optica (NMO) is an autoimmune inflammatory disease of the central nervous system (CNS) characterized by transverse myelitis and optic neuritis. The pathogenic serum IgG antibody against the aquaporin-4 (AQP4) on astrocytes triggers the activation of the complement cascade, causing astr...

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Veröffentlicht in:	Molecular therapy 2023-09, Vol.31 (9), p.2715-2733
Hauptverfasser:	Xu, Li, Xu, Huiming, Chen, Siqi, Jiang, Wei, Afridi, Shabbir Khan, Wang, Yuge, Ren, Xin, Zhao, Yipeng, Lai, Shuiqing, Qiu, Xiusheng, Alvin Huang, Yu-Wen, Cui, Yaxiong, Yang, Hui, Qiu, Wei, Tang, Changyong
Format:	Artikel
Sprache:	eng
Schlagworte:	AAV2/9.CR2-Crry Animals AQP4 Aquaporin 4 - metabolism astrocyte Astrocytes - metabolism C3 signaling Complement C3 - genetics Complement C3 - metabolism Mice motor and visual dysfunction neuroinflammation neuromyelitis optica Neuromyelitis Optica - pathology Original Recombinant Fusion Proteins - metabolism Signal Transduction Vision Disorders - complications Vision Disorders - pathology
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