Efficacy of Boswellia serrata Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Than 40 Years with Persistent Knee Pain: A Randomized Double-Blind Controlled Clinical Trial
A single-center, randomized, double-blind, controlled clinical trial with four arms was conducted in healthy subjects with persistent knee discomfort (pain intensity on 1–10 cm visual analog scale (VAS) > 3) aged 40 years and older treated with a dietary supplement for 8 weeks. The study groups w...
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| Veröffentlicht in: | Nutrients 2023-09, Vol.15 (17), p.3848 |
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| creator | Pérez-Piñero, Silvia Muñoz-Carrillo, Juan Carlos Victoria-Montesinos, Desirée García-Muñoz, Ana María Andreu-Caravaca, Luis Gómez, Mario Schölzel, Melanie García-Guillén, Ana I. López-Román, Francisco Javier |
| description | A single-center, randomized, double-blind, controlled clinical trial with four arms was conducted in healthy subjects with persistent knee discomfort (pain intensity on 1–10 cm visual analog scale (VAS) > 3) aged 40 years and older treated with a dietary supplement for 8 weeks. The study groups were Boswellia serrata extract (n = 29), an omega-3-based product (AvailOm® 50 High EPA) (n = 31), Boswellia + AvailOm® (n = 30), and placebo (n = 30). The intake of Boswellia + AvailOm® improved the quality of life (QoL) (WOMAC index) and some variables of muscle strength. Statistically significant differences between the AvailOm® and the placebo groups in the decrease of pain intensity were found. Weekly VAS scores showed a significant decrease in pain perception when comparing the AvailOm® product to the placebo, with the lowest VAS scores at week 8. Consumption of Boswellia improved sleep latency. The time to perform the Up and Go test decreased after the intake of AvailOm®. There was an increase in the omega-3 fatty acids, with the greatest increase in the Boswellia + AvailOm® group. AvailOm® was safe and effective in reducing pain and improving the QoL and functionality of subjects over 40 years with persistent knee pain. |
| doi_str_mv | 10.3390/nu15173848 |
| format | Article |
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AvailOm® was safe and effective in reducing pain and improving the QoL and functionality of subjects over 40 years with persistent knee pain.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu15173848</identifier><identifier>PMID: 37686880</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Aging ; Analgesics ; Arthritis ; Body composition ; Cartilage ; Chronic illnesses ; Chronic pain ; Clinical trials ; Cytokines ; Dietary supplements ; Disease prevention ; Double-blind studies ; Exercise ; Fatty acids ; Inflammation ; Informed consent ; Knee ; Muscle strength ; Omega-3 fatty acids ; Osteoarthritis ; Physical fitness ; Sleep ; Womens health</subject><ispartof>Nutrients, 2023-09, Vol.15 (17), p.3848</ispartof><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. 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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Aging Analgesics Arthritis Body composition Cartilage Chronic illnesses Chronic pain Clinical trials Cytokines Dietary supplements Disease prevention Double-blind studies Exercise Fatty acids Inflammation Informed consent Knee Muscle strength Omega-3 fatty acids Osteoarthritis Physical fitness Sleep Womens health |
| title | Efficacy of Boswellia serrata Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Than 40 Years with Persistent Knee Pain: A Randomized Double-Blind Controlled Clinical Trial |
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