Photocatalytic and Photothermal Antimicrobial Mussel-Inspired Nanocomposites for Biomedical Applications
Bacterial infection has traditionally been treated with antibiotics, but their overuse is leading to the development of antibiotic resistance. This may be mitigated by alternative approaches to prevent or treat bacterial infections without utilization of antibiotics. Among the alternatives is the us...
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| Veröffentlicht in: | International journal of molecular sciences 2023-09, Vol.24 (17), p.13272 |
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| creator | Soto-Garcia, Luis F Guerrero-Rodriguez, Ingrid D Hoang, Luu Laboy-Segarra, Samantha Lauren Phan, Ngan T. K Villafuerte, Enrique Lee, Juhyun Nguyen, Kytai T |
| description | Bacterial infection has traditionally been treated with antibiotics, but their overuse is leading to the development of antibiotic resistance. This may be mitigated by alternative approaches to prevent or treat bacterial infections without utilization of antibiotics. Among the alternatives is the use of photo-responsive antimicrobial nanoparticles and/or nanocomposites, which present unique properties activated by light. In this study, we explored the combined use of titanium oxide and polydopamine to create nanoparticles with photocatalytic and photothermal antibacterial properties triggered by visible or near-infrared light. Furthermore, as a proof-of-concept, these photo-responsive nanoparticles were combined with mussel-inspired catechol-modified hyaluronic acid hydrogels to form novel light-driven antibacterial nanocomposites. The materials were challenged with models of Gram-negative and Gram-positive bacteria. For visible light, the average percentage killed (PK) was 94.6 for E. coli and 92.3 for S. aureus. For near-infrared light, PK for E. coli reported 52.8 and 99.2 for S. aureus. These results confirm the exciting potential of these nanocomposites to prevent the development of antibiotic resistance and also to open the door for further studies to optimize their composition in order to increase their bactericidal efficacy for biomedical applications. |
| doi_str_mv | 10.3390/ijms241713272 |
| format | Article |
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Furthermore, as a proof-of-concept, these photo-responsive nanoparticles were combined with mussel-inspired catechol-modified hyaluronic acid hydrogels to form novel light-driven antibacterial nanocomposites. The materials were challenged with models of Gram-negative and Gram-positive bacteria. For visible light, the average percentage killed (PK) was 94.6 for E. coli and 92.3 for S. aureus. For near-infrared light, PK for E. coli reported 52.8 and 99.2 for S. aureus. These results confirm the exciting potential of these nanocomposites to prevent the development of antibiotic resistance and also to open the door for further studies to optimize their composition in order to increase their bactericidal efficacy for biomedical applications.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms241713272</identifier><identifier>PMID: 37686076</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Antibiotics ; Antimicrobial agents ; Bacteria ; Bacterial infections ; Biomedical materials ; Carbon ; Catechin ; Chemical reactions ; Dopamine ; Drug delivery systems ; Drug resistance in microorganisms ; E coli ; Escherichia coli ; Health aspects ; Hyaluronic acid ; Hydrogels ; Infection ; Infection control ; Light ; Methicillin ; Nanocomposites ; Nanoparticles ; Photocatalysis ; Polymerization ; Silver ; Skin ; Spectrum analysis ; Thermal energy ; Wound healing</subject><ispartof>International journal of molecular sciences, 2023-09, Vol.24 (17), p.13272</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. 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| subjects | Antibiotics Antimicrobial agents Bacteria Bacterial infections Biomedical materials Carbon Catechin Chemical reactions Dopamine Drug delivery systems Drug resistance in microorganisms E coli Escherichia coli Health aspects Hyaluronic acid Hydrogels Infection Infection control Light Methicillin Nanocomposites Nanoparticles Photocatalysis Polymerization Silver Skin Spectrum analysis Thermal energy Wound healing |
| title | Photocatalytic and Photothermal Antimicrobial Mussel-Inspired Nanocomposites for Biomedical Applications |
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