Applications of CRISPR Technology to Breast Cancer and Triple Negative Breast Cancer Research
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology has transformed oncology research in many ways. Breast cancer is the most prevalent malignancy globally and triple negative breast cancer (TNBC) is one of the most aggressive subtypes with numerous challenges still to be f...
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| Veröffentlicht in: | Cancers 2023-09, Vol.15 (17), p.4364 |
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| creator | Pont, Mariona Marqués, Marta Sorolla, Maria Alba Parisi, Eva Urdanibia, Izaskun Morales, Serafín Salud, Antonieta Sorolla, Anabel |
| description | Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology has transformed oncology research in many ways. Breast cancer is the most prevalent malignancy globally and triple negative breast cancer (TNBC) is one of the most aggressive subtypes with numerous challenges still to be faced. In this work, we have explained what CRISPR consists of and listed its applications in breast cancer while focusing on TNBC research. These are disease modelling, the search for novel genes involved in tumour progression, sensitivity to drugs and immunotherapy response, tumour fitness, diagnosis, and treatment. Additionally, we have listed the current delivery methods employed for the delivery of CRISPR systems in vivo. Lastly, we have highlighted the limitations that CRISPR technology is subject to and the future directions that we envisage. Overall, we have provided a round summary of the aspects concerning CRISPR in breast cancer/TNBC research. |
| doi_str_mv | 10.3390/cancers15174364 |
| format | Article |
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Breast cancer is the most prevalent malignancy globally and triple negative breast cancer (TNBC) is one of the most aggressive subtypes with numerous challenges still to be faced. In this work, we have explained what CRISPR consists of and listed its applications in breast cancer while focusing on TNBC research. These are disease modelling, the search for novel genes involved in tumour progression, sensitivity to drugs and immunotherapy response, tumour fitness, diagnosis, and treatment. Additionally, we have listed the current delivery methods employed for the delivery of CRISPR systems in vivo. Lastly, we have highlighted the limitations that CRISPR technology is subject to and the future directions that we envisage. Overall, we have provided a round summary of the aspects concerning CRISPR in breast cancer/TNBC research.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers15174364</identifier><identifier>PMID: 37686639</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Bacteria ; Breast cancer ; Cancer ; Cancer research ; Cancer therapies ; Cell cycle ; Chemotherapy ; CRISPR ; Development and progression ; Diagnosis ; DNA methylation ; Drug resistance ; Enzymes ; Epidermal growth factor ; Epigenetics ; Genes ; Genetic engineering ; Genomes ; Immunotherapy ; Kinases ; Malignancy ; Medical prognosis ; Medical research ; Metastasis ; Mutation ; Oncology, Experimental ; Proteins ; Review ; Transcription factors ; Tumors</subject><ispartof>Cancers, 2023-09, Vol.15 (17), p.4364</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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| subjects | Bacteria Breast cancer Cancer Cancer research Cancer therapies Cell cycle Chemotherapy CRISPR Development and progression Diagnosis DNA methylation Drug resistance Enzymes Epidermal growth factor Epigenetics Genes Genetic engineering Genomes Immunotherapy Kinases Malignancy Medical prognosis Medical research Metastasis Mutation Oncology, Experimental Proteins Review Transcription factors Tumors |
| title | Applications of CRISPR Technology to Breast Cancer and Triple Negative Breast Cancer Research |
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