The Putative S1PR1 Modulator ACT-209905 Impairs Growth and Migration of Glioblastoma Cells In Vitro

Glioblastoma (GBM) is still a deadly tumor due to its highly infiltrative growth behavior and its resistance to therapy. Evidence is accumulating that sphingosine-1-phosphate (S1P) acts as an important tumor-promoting molecule that is involved in the activation of the S1P receptor subtype 1 (S1PR1)....

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Veröffentlicht in:	Cancers 2023-08, Vol.15 (17), p.4273
Hauptverfasser:	Bien-Möller, Sandra, Chen, Fan, Xiao, Yong, Köppe, Hanjo, Jedlitschky, Gabriele, Meyer, Ulrike, Tolksdorf, Céline, Grube, Markus, Marx, Sascha, Tzvetkov, Mladen V, Schroeder, Henry W. S, Rauch, Bernhard H
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT1 protein Amino acids Cancer Cell culture Cell growth Extracellular signal-regulated kinase Glioblastoma Glioblastoma cells Glioblastoma multiforme Intercellular adhesion molecule 1 Kinases Leukocyte migration Macrophages Medical prognosis Monocytes Motility P-selectin Sphingosine Sphingosine 1-phosphate Tumors
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