Transcription-wide impact by RESCUE-induced off-target single-nucleotide variants in mammalian cells

RNA base editing is a promising tool in precise molecular therapy. Currently, there are two widely used RNA base editors, REPAIR and RESCUE. REPAIR only facilitates A-to-I conversions, while RESCUE performs both A-to-I and C-to-U conversions. Thus, RESCUE can generate twice the number of mutations c...

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Veröffentlicht in:	Journal of molecular cell biology 2023-06, Vol.15 (2)
Hauptverfasser:	Li, Guo, Zhu, Xiaoning, Wang, Yihan, Ma, Hongru, Wang, Yuzhe, Wu, Hanyu, Li, Xiangyang, Wang, Yiling, Gao, Jianen, Chen, Xuexin, Huang, Xingxu, Yao, Yuan, Hu, Xiaoxiang
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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