Mass-like Lesions Causing Compression of Large Vessels in Granulomatosis with Polyangiitis
A 69-year-old woman with a history of otitis media with anti-neutrophil cytoplasmic antibody-associated vasculitis who had been receiving corticosteroid monotherapy presented with shortness of breath. The otitis media had been alleviated, but she had saddle nose. Chest enhanced computed tomography s...
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| Veröffentlicht in: | Internal Medicine 2023/08/15, Vol.62(16), pp.2427-2431 |
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| container_issue | 16 |
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| container_title | Internal Medicine |
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| creator | Hanzawa, Satoshi Noda, Seiji Hosoya, Tadashi Kawahara, Tatsuo Nukui, Yoshihisa |
| description | A 69-year-old woman with a history of otitis media with anti-neutrophil cytoplasmic antibody-associated vasculitis who had been receiving corticosteroid monotherapy presented with shortness of breath. The otitis media had been alleviated, but she had saddle nose. Chest enhanced computed tomography showed stenoses of the bronchi and large vessels surrounded by mass-like lesions in the mediastinum. These manifestations indicated an active state of granulomatosis with polyangiitis (GPA). After she was started on high-dose corticosteroids and intravenous cyclophosphamide, the mass-like lesions disappeared with improvements of the stenoses. Ameliorating mass-like lesions resulting from GPA requires therapeutic intervention using corticosteroids and immunosuppressants. |
| doi_str_mv | 10.2169/internalmedicine.0561-22 |
| format | Article |
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The otitis media had been alleviated, but she had saddle nose. Chest enhanced computed tomography showed stenoses of the bronchi and large vessels surrounded by mass-like lesions in the mediastinum. These manifestations indicated an active state of granulomatosis with polyangiitis (GPA). After she was started on high-dose corticosteroids and intravenous cyclophosphamide, the mass-like lesions disappeared with improvements of the stenoses. Ameliorating mass-like lesions resulting from GPA requires therapeutic intervention using corticosteroids and immunosuppressants.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.0561-22</identifier><identifier>PMID: 36575013</identifier><language>eng</language><publisher>Tokyo: The Japanese Society of Internal Medicine</publisher><subject>bronchoscopy ; Bronchus ; Case Report ; Computed tomography ; Corticosteroids ; Cyclophosphamide ; enhanced computed tomography image ; Granulomatosis ; granulomatosis with polyangiitis ; Immunosuppressive agents ; Internal medicine ; Lesions ; Leukocytes (neutrophilic) ; mass-like lesion ; Mediastinum ; Otitis media ; otitis media with anti-neutrophil cytoplasmic antibody-associated vasculitis ; stenosis ; Vasculitis</subject><ispartof>Internal Medicine, 2023/08/15, Vol.62(16), pp.2427-2431</ispartof><rights>2023 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2023</rights><rights>Copyright © 2023 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c588t-b8bbbc4669b0affe8487d6b6ce0badf68e85495bf4b42873dc9656796d9c24c53</citedby><cites>FETCH-LOGICAL-c588t-b8bbbc4669b0affe8487d6b6ce0badf68e85495bf4b42873dc9656796d9c24c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484770/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484770/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1883,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Hanzawa, Satoshi</creatorcontrib><creatorcontrib>Noda, Seiji</creatorcontrib><creatorcontrib>Hosoya, Tadashi</creatorcontrib><creatorcontrib>Kawahara, Tatsuo</creatorcontrib><creatorcontrib>Nukui, Yoshihisa</creatorcontrib><title>Mass-like Lesions Causing Compression of Large Vessels in Granulomatosis with Polyangiitis</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A 69-year-old woman with a history of otitis media with anti-neutrophil cytoplasmic antibody-associated vasculitis who had been receiving corticosteroid monotherapy presented with shortness of breath. The otitis media had been alleviated, but she had saddle nose. Chest enhanced computed tomography showed stenoses of the bronchi and large vessels surrounded by mass-like lesions in the mediastinum. These manifestations indicated an active state of granulomatosis with polyangiitis (GPA). After she was started on high-dose corticosteroids and intravenous cyclophosphamide, the mass-like lesions disappeared with improvements of the stenoses. Ameliorating mass-like lesions resulting from GPA requires therapeutic intervention using corticosteroids and immunosuppressants.</description><subject>bronchoscopy</subject><subject>Bronchus</subject><subject>Case Report</subject><subject>Computed tomography</subject><subject>Corticosteroids</subject><subject>Cyclophosphamide</subject><subject>enhanced computed tomography image</subject><subject>Granulomatosis</subject><subject>granulomatosis with polyangiitis</subject><subject>Immunosuppressive agents</subject><subject>Internal medicine</subject><subject>Lesions</subject><subject>Leukocytes (neutrophilic)</subject><subject>mass-like lesion</subject><subject>Mediastinum</subject><subject>Otitis media</subject><subject>otitis media with anti-neutrophil cytoplasmic antibody-associated vasculitis</subject><subject>stenosis</subject><subject>Vasculitis</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNplkUGP0zAQhS0EYsvCf7DEhUsW27Ed-4RQxS5IRcsBOHCxHGeSujh2sRPQ_nsStarEcpmRZr73NJqHEKbkhlGp3_o4QY42jNB55yPcECFpxdgTtKE111XDavEUbYimqmJLuUIvSjkQUqtGs-foqpaiEYTWG_Tjsy2lCv4n4B0Un2LBWzsXHwe8TeMxQ1mHOPV4Z_MA-PsygFCwj_gu2ziHNNopFV_wHz_t8ZcUHmwcvJ98eYme9TYUeHXu1-jb7Yev24_V7v7u0_b9rnJCqalqVdu2jkupW2L7HhRXTSdb6YC0tuulAiW4Fm3PW85UU3dOSyEbLTvtGHeivkbvTr7HuV0e4iBO2QZzzH60-cEk682_m-j3Zki_DSVc8aYhi8Obs0NOv2Yokxl9cRCCjZDmYlgjNCFUKbqgrx-hhzSvUSyUknwhKOcLpU6Uy6mUDP3lGkrMmqB5nKBZEzSMLdL7k_RQJjvARWjz5F2A_4WSGSrXena4kG5vs4FY_wWwlrJg</recordid><startdate>20230815</startdate><enddate>20230815</enddate><creator>Hanzawa, Satoshi</creator><creator>Noda, Seiji</creator><creator>Hosoya, Tadashi</creator><creator>Kawahara, Tatsuo</creator><creator>Nukui, Yoshihisa</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230815</creationdate><title>Mass-like Lesions Causing Compression of Large Vessels in Granulomatosis with Polyangiitis</title><author>Hanzawa, Satoshi ; Noda, Seiji ; Hosoya, Tadashi ; Kawahara, Tatsuo ; Nukui, Yoshihisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c588t-b8bbbc4669b0affe8487d6b6ce0badf68e85495bf4b42873dc9656796d9c24c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>bronchoscopy</topic><topic>Bronchus</topic><topic>Case Report</topic><topic>Computed tomography</topic><topic>Corticosteroids</topic><topic>Cyclophosphamide</topic><topic>enhanced computed tomography image</topic><topic>Granulomatosis</topic><topic>granulomatosis with polyangiitis</topic><topic>Immunosuppressive agents</topic><topic>Internal medicine</topic><topic>Lesions</topic><topic>Leukocytes (neutrophilic)</topic><topic>mass-like lesion</topic><topic>Mediastinum</topic><topic>Otitis media</topic><topic>otitis media with anti-neutrophil cytoplasmic antibody-associated vasculitis</topic><topic>stenosis</topic><topic>Vasculitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hanzawa, Satoshi</creatorcontrib><creatorcontrib>Noda, Seiji</creatorcontrib><creatorcontrib>Hosoya, Tadashi</creatorcontrib><creatorcontrib>Kawahara, Tatsuo</creatorcontrib><creatorcontrib>Nukui, Yoshihisa</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hanzawa, Satoshi</au><au>Noda, Seiji</au><au>Hosoya, Tadashi</au><au>Kawahara, Tatsuo</au><au>Nukui, Yoshihisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mass-like Lesions Causing Compression of Large Vessels in Granulomatosis with Polyangiitis</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2023-08-15</date><risdate>2023</risdate><volume>62</volume><issue>16</issue><spage>2427</spage><epage>2431</epage><pages>2427-2431</pages><artnum>0561-22</artnum><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>A 69-year-old woman with a history of otitis media with anti-neutrophil cytoplasmic antibody-associated vasculitis who had been receiving corticosteroid monotherapy presented with shortness of breath. The otitis media had been alleviated, but she had saddle nose. Chest enhanced computed tomography showed stenoses of the bronchi and large vessels surrounded by mass-like lesions in the mediastinum. These manifestations indicated an active state of granulomatosis with polyangiitis (GPA). After she was started on high-dose corticosteroids and intravenous cyclophosphamide, the mass-like lesions disappeared with improvements of the stenoses. Ameliorating mass-like lesions resulting from GPA requires therapeutic intervention using corticosteroids and immunosuppressants.</abstract><cop>Tokyo</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>36575013</pmid><doi>10.2169/internalmedicine.0561-22</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | bronchoscopy Bronchus Case Report Computed tomography Corticosteroids Cyclophosphamide enhanced computed tomography image Granulomatosis granulomatosis with polyangiitis Immunosuppressive agents Internal medicine Lesions Leukocytes (neutrophilic) mass-like lesion Mediastinum Otitis media otitis media with anti-neutrophil cytoplasmic antibody-associated vasculitis stenosis Vasculitis |
| title | Mass-like Lesions Causing Compression of Large Vessels in Granulomatosis with Polyangiitis |
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