Acute Myocardial Infarction Due to Coronary Artery Embolism during Chemotherapy with mFOLFOX-6 Plus Bevacizumab for Metastatic Colon Cancer
Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, may be associated with arterial embolisms. We herein report a case of acute myocardial infarction caused by coronary embolism during combination chemotherapy with mFOLFOX-6 and bevacizumab in a patient with metastatic col...
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| Veröffentlicht in: | Internal Medicine 2023/08/15, Vol.62(16), pp.2361-2364 |
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| creator | Aoshima, Hiroyuki Tawarahara, Kei Kato, Haruta Ishibashi, Fumimaro Tokonami, Yuki Nakamura, Naoki Matsukura, Gaku Kanda, Takahiro Ozeki, Mariko Ukigai, Hiroshi Takeuchi, Ryosuke |
| description | Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, may be associated with arterial embolisms. We herein report a case of acute myocardial infarction caused by coronary embolism during combination chemotherapy with mFOLFOX-6 and bevacizumab in a patient with metastatic colon cancer. Thromboembolism occurred only in the distal right posterolateral branch without stenotic lesions or plaque rupture in the proximal branch of the right coronary artery. Sole thromboaspiration was successfully performed; the final angiogram demonstrated no stenosis in the right coronary artery. Bevacizumab may be associated with acute coronary syndrome in patients with coronary risk factors, despite no significant coronary narrowing. |
| doi_str_mv | 10.2169/internalmedicine.0788-22 |
| format | Article |
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We herein report a case of acute myocardial infarction caused by coronary embolism during combination chemotherapy with mFOLFOX-6 and bevacizumab in a patient with metastatic colon cancer. Thromboembolism occurred only in the distal right posterolateral branch without stenotic lesions or plaque rupture in the proximal branch of the right coronary artery. Sole thromboaspiration was successfully performed; the final angiogram demonstrated no stenosis in the right coronary artery. Bevacizumab may be associated with acute coronary syndrome in patients with coronary risk factors, despite no significant coronary narrowing.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.0788-22</identifier><identifier>PMID: 36450471</identifier><language>eng</language><publisher>Tokyo: The Japanese Society of Internal Medicine</publisher><subject>acute myocardial infarction ; anti-VEGF inhibitors ; Bevacizumab ; Case Report ; Case reports ; Chemotherapy ; Colon cancer ; Coronary artery ; coronary artery embolism ; Embolism ; Internal medicine ; Metastases ; Monoclonal antibodies ; Myocardial infarction ; Risk factors ; Stenosis ; Thromboembolism ; Vascular endothelial growth factor</subject><ispartof>Internal Medicine, 2023/08/15, Vol.62(16), pp.2361-2364</ispartof><rights>2023 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2023</rights><rights>Copyright © 2023 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c588t-114e2131c92dcc15307c54df0d0170c431dd4a020a6bd02ae7a26ee7eb8984df3</citedby><cites>FETCH-LOGICAL-c588t-114e2131c92dcc15307c54df0d0170c431dd4a020a6bd02ae7a26ee7eb8984df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484765/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484765/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,1879,27907,27908,53774,53776</link.rule.ids></links><search><creatorcontrib>Aoshima, Hiroyuki</creatorcontrib><creatorcontrib>Tawarahara, Kei</creatorcontrib><creatorcontrib>Kato, Haruta</creatorcontrib><creatorcontrib>Ishibashi, Fumimaro</creatorcontrib><creatorcontrib>Tokonami, Yuki</creatorcontrib><creatorcontrib>Nakamura, Naoki</creatorcontrib><creatorcontrib>Matsukura, Gaku</creatorcontrib><creatorcontrib>Kanda, Takahiro</creatorcontrib><creatorcontrib>Ozeki, Mariko</creatorcontrib><creatorcontrib>Ukigai, Hiroshi</creatorcontrib><creatorcontrib>Takeuchi, Ryosuke</creatorcontrib><title>Acute Myocardial Infarction Due to Coronary Artery Embolism during Chemotherapy with mFOLFOX-6 Plus Bevacizumab for Metastatic Colon Cancer</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, may be associated with arterial embolisms. We herein report a case of acute myocardial infarction caused by coronary embolism during combination chemotherapy with mFOLFOX-6 and bevacizumab in a patient with metastatic colon cancer. Thromboembolism occurred only in the distal right posterolateral branch without stenotic lesions or plaque rupture in the proximal branch of the right coronary artery. Sole thromboaspiration was successfully performed; the final angiogram demonstrated no stenosis in the right coronary artery. Bevacizumab may be associated with acute coronary syndrome in patients with coronary risk factors, despite no significant coronary narrowing.</description><subject>acute myocardial infarction</subject><subject>anti-VEGF inhibitors</subject><subject>Bevacizumab</subject><subject>Case Report</subject><subject>Case reports</subject><subject>Chemotherapy</subject><subject>Colon cancer</subject><subject>Coronary artery</subject><subject>coronary artery embolism</subject><subject>Embolism</subject><subject>Internal medicine</subject><subject>Metastases</subject><subject>Monoclonal antibodies</subject><subject>Myocardial infarction</subject><subject>Risk factors</subject><subject>Stenosis</subject><subject>Thromboembolism</subject><subject>Vascular endothelial growth factor</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNplkcGO0zAQhiPEii0L72CJC5cstuPYzgmVsIWVuioHkLhZrjNtXCV2sZ1F5RV4aVy1qsTuZSzZ3__PeP6iQATfUsKbD9YlCE4PI3TWWAe3WEhZUvqimJGKNaWgVf2ymOGG5NtcrovXMe4wrqRo6KviuuKsxkyQWfF3bqYE6OHgjQ6d1QO6dxsdTLLeoc8ToORR64N3OhzQPOS2B3Q3rv1g44i6KVi3RW0Po089BL0_oN829WhcrJaL1c-So2_DFNEneNTG_plGvUYbH9ADJB2TTtZk7yE3arUzEN4UVxs9RHh7Pm-KH4u77-3Xcrn6ct_Ol6WppUwlIQwoqYhpaGcMqSssTM26De4wEdiwinQd05hizdcdphqEphxAwFo2MnPVTfHx5Luf1nmDBlwKelD7YMf8S-W1Vf-_ONurrX9UBDPJBK-zw_uzQ_C_JohJjTYaGAbtwE9RUcEY5w0WOKPvnqA7Px2zy5TkTBLacJIpeaJM8DEG2FymIVgdI1dPI1fHyBWlWbo6SXd5pVu4CHXI-x3guZBTRfixnh0upOl1UOCqfzj-wrc</recordid><startdate>20230815</startdate><enddate>20230815</enddate><creator>Aoshima, Hiroyuki</creator><creator>Tawarahara, Kei</creator><creator>Kato, Haruta</creator><creator>Ishibashi, Fumimaro</creator><creator>Tokonami, Yuki</creator><creator>Nakamura, Naoki</creator><creator>Matsukura, Gaku</creator><creator>Kanda, Takahiro</creator><creator>Ozeki, Mariko</creator><creator>Ukigai, Hiroshi</creator><creator>Takeuchi, Ryosuke</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230815</creationdate><title>Acute Myocardial Infarction Due to Coronary Artery Embolism during Chemotherapy with mFOLFOX-6 Plus Bevacizumab for Metastatic Colon Cancer</title><author>Aoshima, Hiroyuki ; Tawarahara, Kei ; Kato, Haruta ; Ishibashi, Fumimaro ; Tokonami, Yuki ; Nakamura, Naoki ; Matsukura, Gaku ; Kanda, Takahiro ; Ozeki, Mariko ; Ukigai, Hiroshi ; Takeuchi, Ryosuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c588t-114e2131c92dcc15307c54df0d0170c431dd4a020a6bd02ae7a26ee7eb8984df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>acute myocardial infarction</topic><topic>anti-VEGF inhibitors</topic><topic>Bevacizumab</topic><topic>Case Report</topic><topic>Case reports</topic><topic>Chemotherapy</topic><topic>Colon cancer</topic><topic>Coronary artery</topic><topic>coronary artery embolism</topic><topic>Embolism</topic><topic>Internal medicine</topic><topic>Metastases</topic><topic>Monoclonal antibodies</topic><topic>Myocardial infarction</topic><topic>Risk factors</topic><topic>Stenosis</topic><topic>Thromboembolism</topic><topic>Vascular endothelial growth factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aoshima, Hiroyuki</creatorcontrib><creatorcontrib>Tawarahara, Kei</creatorcontrib><creatorcontrib>Kato, Haruta</creatorcontrib><creatorcontrib>Ishibashi, Fumimaro</creatorcontrib><creatorcontrib>Tokonami, Yuki</creatorcontrib><creatorcontrib>Nakamura, Naoki</creatorcontrib><creatorcontrib>Matsukura, Gaku</creatorcontrib><creatorcontrib>Kanda, Takahiro</creatorcontrib><creatorcontrib>Ozeki, Mariko</creatorcontrib><creatorcontrib>Ukigai, Hiroshi</creatorcontrib><creatorcontrib>Takeuchi, Ryosuke</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aoshima, Hiroyuki</au><au>Tawarahara, Kei</au><au>Kato, Haruta</au><au>Ishibashi, Fumimaro</au><au>Tokonami, Yuki</au><au>Nakamura, Naoki</au><au>Matsukura, Gaku</au><au>Kanda, Takahiro</au><au>Ozeki, Mariko</au><au>Ukigai, Hiroshi</au><au>Takeuchi, Ryosuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute Myocardial Infarction Due to Coronary Artery Embolism during Chemotherapy with mFOLFOX-6 Plus Bevacizumab for Metastatic Colon Cancer</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2023-08-15</date><risdate>2023</risdate><volume>62</volume><issue>16</issue><spage>2361</spage><epage>2364</epage><pages>2361-2364</pages><artnum>0788-22</artnum><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, may be associated with arterial embolisms. We herein report a case of acute myocardial infarction caused by coronary embolism during combination chemotherapy with mFOLFOX-6 and bevacizumab in a patient with metastatic colon cancer. Thromboembolism occurred only in the distal right posterolateral branch without stenotic lesions or plaque rupture in the proximal branch of the right coronary artery. Sole thromboaspiration was successfully performed; the final angiogram demonstrated no stenosis in the right coronary artery. Bevacizumab may be associated with acute coronary syndrome in patients with coronary risk factors, despite no significant coronary narrowing.</abstract><cop>Tokyo</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>36450471</pmid><doi>10.2169/internalmedicine.0788-22</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | acute myocardial infarction anti-VEGF inhibitors Bevacizumab Case Report Case reports Chemotherapy Colon cancer Coronary artery coronary artery embolism Embolism Internal medicine Metastases Monoclonal antibodies Myocardial infarction Risk factors Stenosis Thromboembolism Vascular endothelial growth factor |
| title | Acute Myocardial Infarction Due to Coronary Artery Embolism during Chemotherapy with mFOLFOX-6 Plus Bevacizumab for Metastatic Colon Cancer |
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