Particle Metrology Approach to Understanding How Storage Conditions Affect Long-Term Liposome Stability

Lipid nanoparticles are a generic type of nanomaterial with broad applicability in medicine as drug delivery vehicles. Liposomes are a subtype of lipid nanoparticles and, as a therapeutic platform, can be loaded with a genetic material or pharmaceutical agents for use as drug treatments. An open que...

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Veröffentlicht in:Langmuir 2023-09, Vol.39 (35), p.12313-12323
Hauptverfasser: Lehman, Sean E., Benkstein, Kurt D., Cleveland, Thomas E., Anderson, Kyle W., Carrier, Michael J., Vreeland, Wyatt N.
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container_end_page 12323
container_issue 35
container_start_page 12313
container_title Langmuir
container_volume 39
creator Lehman, Sean E.
Benkstein, Kurt D.
Cleveland, Thomas E.
Anderson, Kyle W.
Carrier, Michael J.
Vreeland, Wyatt N.
description Lipid nanoparticles are a generic type of nanomaterial with broad applicability in medicine as drug delivery vehicles. Liposomes are a subtype of lipid nanoparticles and, as a therapeutic platform, can be loaded with a genetic material or pharmaceutical agents for use as drug treatments. An open question for these types of lipid nanoparticles is what factor(s) affect the long-term stability of the particles. The stability of the particle is of great interest to understand and predict the effective shelf-life and storage requirements. In this report, we detail a one-year study of liposome stability as a function of lipid composition, buffer composition/pH, and storage temperature. This was done in aqueous solution without freezing. The effect of lipid composition is shown to be a critical factor when evaluating stability of the measured particle size and number concentration. Other factors (i.e., storage temperature and buffer pH/composition) were shown to be less critical but still have some effect. The stability of these particles informs formulation and optimal storage requirements and assists with future developmental planning of a NIST liposome-based reference material. This work also highlights the complex nature of long-term soft particle storage in biopharmaceutical applications.
doi_str_mv 10.1021/acs.langmuir.3c01270
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subjects Biological Products
Biotin
Drug Delivery Systems
Lipids
Liposomes
title Particle Metrology Approach to Understanding How Storage Conditions Affect Long-Term Liposome Stability
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