Establishment of paternal methylation imprint at the H19/Igf2 imprinting control region

The insulator model explains the workings of the H19 and Igf2 imprinted domain in the soma, where insulation of the Igf2 promoter from its enhancers occurs by CTCF in the maternally inherited unmethylated chromosome but not the paternally inherited methylated allele. The molecular mechanism that tar...

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Veröffentlicht in:	Science advances 2023-09, Vol.9 (36), p.eadi2050-eadi2050
Hauptverfasser:	Liao, Ji, Song, Sangmin, Gusscott, Samuel, Fu, Zhen, VanderKolk, Ivan, Busscher, Brianna M., Lau, Kin H., Brind’Amour, Julie, Szabó, Piroska E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedicine and Life Sciences Genetics SciAdv r-articles
Online-Zugang:	Volltext
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