Bacterial immunotherapy is highly effective in reducing recurrent upper respiratory tract infections in children: a prospective observational study
Purpose Whilst immunotherapy is an appealing option as it could reduce the burden of recurrent pediatric respiratory tract infections (RTI), there is limited evidence on its effectiveness and more research was requested in order to better understand this therapeutic modality. Methods We performed a...
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| Veröffentlicht in: | European archives of oto-rhino-laryngology 2023-10, Vol.280 (10), p.4519-4530 |
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| creator | Rebolledo, Laura Rodríguez-Vigil, Carmen Carmen, Luis Llorente, Eva Guallar, María Villoria, Jesús Vicente, Eugenio |
| description | Purpose
Whilst immunotherapy is an appealing option as it could reduce the burden of recurrent pediatric respiratory tract infections (RTI), there is limited evidence on its effectiveness and more research was requested in order to better understand this therapeutic modality.
Methods
We performed a prospective cohort study involving 57 subjects to assess the safety and effectiveness a 3-month regimen of either typified or patient-specific bacterial lysates could have in reducing the number of RTIs in children aged 0 to 11 years with histories of recurrent episodes.
Results
After a 6-month follow-up, the number of RTIs and school absenteeism dropped sharply and significantly, from an adjusted mean (standard error) of 0.6 (0.04) episodes/month to 0.1 (0.03) episodes/month (74.7% reduction,
P
|
| doi_str_mv | 10.1007/s00405-023-08035-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10477114</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2821340474</sourcerecordid><originalsourceid>FETCH-LOGICAL-c447t-5e8b0c745a6c62b2e281a813b01ef061e65842648a57dac73525d89d87bc72793</originalsourceid><addsrcrecordid>eNp9kcuO1DAQRS0EYpqGH2CBvGQTKL_iNBvEjHhJI7GBteU4lY5HSRzspKV8Bz-MM92MYMPKturc66q6hLxk8IYB6LcJQIIqgIsCKhCqkI_IjkkhC6l5-Zjs4CB0IaXWV-RZSncAoORBPCVXQnMlAdiO_Lq2bsbobU_9MCxjmDuMdlqpT7Tzx65fKbYtutmfkPqRRmwW58djvrglRhxnukwTxvxOk492DnGlc8ymmb7XhTFtQtf5vsn8O2rpFEOaLp6hThhPduNyD2lemvU5edLaPuGLy7knPz59_H7zpbj99vnrzYfbwuWZ5kJhVYPTUtnSlbzmyCtmKyZqYNhCybBUleSlrKzSjXVaKK6a6tBUunaa64PYk_dn32mpB2xcHiba3kzRDzauJlhv_q2MvjPHcDIM8k5Z3vSevL44xPBzwTSbwSeHfW9HDEsyvOJMyExvKD-jLg-fIrYP_zAwW5zmHKfJcZr7OM0mevV3hw-SP_llQJyBlEvjEaO5C0vMm0z_s_0NCrqwAw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2821340474</pqid></control><display><type>article</type><title>Bacterial immunotherapy is highly effective in reducing recurrent upper respiratory tract infections in children: a prospective observational study</title><source>SpringerLink Journals - AutoHoldings</source><creator>Rebolledo, Laura ; Rodríguez-Vigil, Carmen ; Carmen, Luis ; Llorente, Eva ; Guallar, María ; Villoria, Jesús ; Vicente, Eugenio</creator><creatorcontrib>Rebolledo, Laura ; Rodríguez-Vigil, Carmen ; Carmen, Luis ; Llorente, Eva ; Guallar, María ; Villoria, Jesús ; Vicente, Eugenio</creatorcontrib><description>Purpose
Whilst immunotherapy is an appealing option as it could reduce the burden of recurrent pediatric respiratory tract infections (RTI), there is limited evidence on its effectiveness and more research was requested in order to better understand this therapeutic modality.
Methods
We performed a prospective cohort study involving 57 subjects to assess the safety and effectiveness a 3-month regimen of either typified or patient-specific bacterial lysates could have in reducing the number of RTIs in children aged 0 to 11 years with histories of recurrent episodes.
Results
After a 6-month follow-up, the number of RTIs and school absenteeism dropped sharply and significantly, from an adjusted mean (standard error) of 0.6 (0.04) episodes/month to 0.1 (0.03) episodes/month (74.7% reduction,
P
< 0.001), and from an adjusted mean score of 4.6 (1.06) points to 0.0 (0.01) points over 10 (99.5% reduction,
P
< 0.001), respectively. There was also a significant decrease in the severity of symptoms. No adverse reactions were observed.
Conclusion
The use of the study product is associated with a decreased risk of recurrent RTIs in children, with a very favorable safety profile that warrants further investigation in randomized clinical trials.</description><identifier>ISSN: 0937-4477</identifier><identifier>EISSN: 1434-4726</identifier><identifier>DOI: 10.1007/s00405-023-08035-4</identifier><identifier>PMID: 37254001</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Head and Neck Surgery ; Medicine ; Medicine & Public Health ; Neurosurgery ; Otorhinolaryngology ; Rhinology</subject><ispartof>European archives of oto-rhino-laryngology, 2023-10, Vol.280 (10), p.4519-4530</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-5e8b0c745a6c62b2e281a813b01ef061e65842648a57dac73525d89d87bc72793</citedby><cites>FETCH-LOGICAL-c447t-5e8b0c745a6c62b2e281a813b01ef061e65842648a57dac73525d89d87bc72793</cites><orcidid>0000-0002-5911-1667 ; 0000-0003-1169-6499 ; 0000-0002-9377-2610 ; 0000-0001-6724-5158 ; 0000-0001-7518-2257 ; 0000-0001-6508-9083 ; 0000-0002-4282-2139</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00405-023-08035-4$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00405-023-08035-4$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37254001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rebolledo, Laura</creatorcontrib><creatorcontrib>Rodríguez-Vigil, Carmen</creatorcontrib><creatorcontrib>Carmen, Luis</creatorcontrib><creatorcontrib>Llorente, Eva</creatorcontrib><creatorcontrib>Guallar, María</creatorcontrib><creatorcontrib>Villoria, Jesús</creatorcontrib><creatorcontrib>Vicente, Eugenio</creatorcontrib><title>Bacterial immunotherapy is highly effective in reducing recurrent upper respiratory tract infections in children: a prospective observational study</title><title>European archives of oto-rhino-laryngology</title><addtitle>Eur Arch Otorhinolaryngol</addtitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><description>Purpose
Whilst immunotherapy is an appealing option as it could reduce the burden of recurrent pediatric respiratory tract infections (RTI), there is limited evidence on its effectiveness and more research was requested in order to better understand this therapeutic modality.
Methods
We performed a prospective cohort study involving 57 subjects to assess the safety and effectiveness a 3-month regimen of either typified or patient-specific bacterial lysates could have in reducing the number of RTIs in children aged 0 to 11 years with histories of recurrent episodes.
Results
After a 6-month follow-up, the number of RTIs and school absenteeism dropped sharply and significantly, from an adjusted mean (standard error) of 0.6 (0.04) episodes/month to 0.1 (0.03) episodes/month (74.7% reduction,
P
< 0.001), and from an adjusted mean score of 4.6 (1.06) points to 0.0 (0.01) points over 10 (99.5% reduction,
P
< 0.001), respectively. There was also a significant decrease in the severity of symptoms. No adverse reactions were observed.
Conclusion
The use of the study product is associated with a decreased risk of recurrent RTIs in children, with a very favorable safety profile that warrants further investigation in randomized clinical trials.</description><subject>Head and Neck Surgery</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosurgery</subject><subject>Otorhinolaryngology</subject><subject>Rhinology</subject><issn>0937-4477</issn><issn>1434-4726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kcuO1DAQRS0EYpqGH2CBvGQTKL_iNBvEjHhJI7GBteU4lY5HSRzspKV8Bz-MM92MYMPKturc66q6hLxk8IYB6LcJQIIqgIsCKhCqkI_IjkkhC6l5-Zjs4CB0IaXWV-RZSncAoORBPCVXQnMlAdiO_Lq2bsbobU_9MCxjmDuMdlqpT7Tzx65fKbYtutmfkPqRRmwW58djvrglRhxnukwTxvxOk492DnGlc8ymmb7XhTFtQtf5vsn8O2rpFEOaLp6hThhPduNyD2lemvU5edLaPuGLy7knPz59_H7zpbj99vnrzYfbwuWZ5kJhVYPTUtnSlbzmyCtmKyZqYNhCybBUleSlrKzSjXVaKK6a6tBUunaa64PYk_dn32mpB2xcHiba3kzRDzauJlhv_q2MvjPHcDIM8k5Z3vSevL44xPBzwTSbwSeHfW9HDEsyvOJMyExvKD-jLg-fIrYP_zAwW5zmHKfJcZr7OM0mevV3hw-SP_llQJyBlEvjEaO5C0vMm0z_s_0NCrqwAw</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Rebolledo, Laura</creator><creator>Rodríguez-Vigil, Carmen</creator><creator>Carmen, Luis</creator><creator>Llorente, Eva</creator><creator>Guallar, María</creator><creator>Villoria, Jesús</creator><creator>Vicente, Eugenio</creator><general>Springer Berlin Heidelberg</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5911-1667</orcidid><orcidid>https://orcid.org/0000-0003-1169-6499</orcidid><orcidid>https://orcid.org/0000-0002-9377-2610</orcidid><orcidid>https://orcid.org/0000-0001-6724-5158</orcidid><orcidid>https://orcid.org/0000-0001-7518-2257</orcidid><orcidid>https://orcid.org/0000-0001-6508-9083</orcidid><orcidid>https://orcid.org/0000-0002-4282-2139</orcidid></search><sort><creationdate>20231001</creationdate><title>Bacterial immunotherapy is highly effective in reducing recurrent upper respiratory tract infections in children: a prospective observational study</title><author>Rebolledo, Laura ; Rodríguez-Vigil, Carmen ; Carmen, Luis ; Llorente, Eva ; Guallar, María ; Villoria, Jesús ; Vicente, Eugenio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-5e8b0c745a6c62b2e281a813b01ef061e65842648a57dac73525d89d87bc72793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Head and Neck Surgery</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosurgery</topic><topic>Otorhinolaryngology</topic><topic>Rhinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rebolledo, Laura</creatorcontrib><creatorcontrib>Rodríguez-Vigil, Carmen</creatorcontrib><creatorcontrib>Carmen, Luis</creatorcontrib><creatorcontrib>Llorente, Eva</creatorcontrib><creatorcontrib>Guallar, María</creatorcontrib><creatorcontrib>Villoria, Jesús</creatorcontrib><creatorcontrib>Vicente, Eugenio</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European archives of oto-rhino-laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rebolledo, Laura</au><au>Rodríguez-Vigil, Carmen</au><au>Carmen, Luis</au><au>Llorente, Eva</au><au>Guallar, María</au><au>Villoria, Jesús</au><au>Vicente, Eugenio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bacterial immunotherapy is highly effective in reducing recurrent upper respiratory tract infections in children: a prospective observational study</atitle><jtitle>European archives of oto-rhino-laryngology</jtitle><stitle>Eur Arch Otorhinolaryngol</stitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>280</volume><issue>10</issue><spage>4519</spage><epage>4530</epage><pages>4519-4530</pages><issn>0937-4477</issn><eissn>1434-4726</eissn><abstract>Purpose
Whilst immunotherapy is an appealing option as it could reduce the burden of recurrent pediatric respiratory tract infections (RTI), there is limited evidence on its effectiveness and more research was requested in order to better understand this therapeutic modality.
Methods
We performed a prospective cohort study involving 57 subjects to assess the safety and effectiveness a 3-month regimen of either typified or patient-specific bacterial lysates could have in reducing the number of RTIs in children aged 0 to 11 years with histories of recurrent episodes.
Results
After a 6-month follow-up, the number of RTIs and school absenteeism dropped sharply and significantly, from an adjusted mean (standard error) of 0.6 (0.04) episodes/month to 0.1 (0.03) episodes/month (74.7% reduction,
P
< 0.001), and from an adjusted mean score of 4.6 (1.06) points to 0.0 (0.01) points over 10 (99.5% reduction,
P
< 0.001), respectively. There was also a significant decrease in the severity of symptoms. No adverse reactions were observed.
Conclusion
The use of the study product is associated with a decreased risk of recurrent RTIs in children, with a very favorable safety profile that warrants further investigation in randomized clinical trials.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37254001</pmid><doi>10.1007/s00405-023-08035-4</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-5911-1667</orcidid><orcidid>https://orcid.org/0000-0003-1169-6499</orcidid><orcidid>https://orcid.org/0000-0002-9377-2610</orcidid><orcidid>https://orcid.org/0000-0001-6724-5158</orcidid><orcidid>https://orcid.org/0000-0001-7518-2257</orcidid><orcidid>https://orcid.org/0000-0001-6508-9083</orcidid><orcidid>https://orcid.org/0000-0002-4282-2139</orcidid><oa>free_for_read</oa></addata></record> |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Head and Neck Surgery Medicine Medicine & Public Health Neurosurgery Otorhinolaryngology Rhinology |
| title | Bacterial immunotherapy is highly effective in reducing recurrent upper respiratory tract infections in children: a prospective observational study |
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