LEF1 enhances β-catenin transactivation through IDR-dependent liquid–liquid phase separation

Wnt/β-catenin signaling plays a crucial role in cancer development, primarily activated by β-catenin forming a transcription complex with LEF/TCF in the nucleus and initiating the transcription of Wnt target genes. Here, we report that LEF1, a member of the LEF/TCF family, can form intrinsically dis...

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Veröffentlicht in:	Life science alliance 2023-11, Vol.6 (11), p.e202302118
Hauptverfasser:	Zhao, Bing, Li, Zhuoxin, Yu, Shaoqing, Li, Tingting, Wang, Wen, Liu, Ran, Zhang, Biyu, Fang, Xiya, Shen, Yezhuang, Han, Qiuying, Xu, Xin, Wang, Kai, Gong, Weili, Li, Tao, Li, Ailing, Zhou, Tao, Li, Weihua, Li, Teng
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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