A detailed kinetic model of glycolysis in Plasmodium falciparum-infected red blood cells for antimalarial drug target identification

Upon infection by the malaria parasite Plasmodium falciparum, the glycolytic rate of a red blood cell increases up to 100-fold, possibly contributing to lactic acidosis and hypoglycemia in patients with severe malaria. This dramatic increase in glucose uptake and metabolism was correctly predicted b...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of biological chemistry 2023-09, Vol.299 (9), p.105111-105111, Article 105111
Hauptverfasser:	van Niekerk, David D., du Toit, Francois, Green, Kathleen, Palm, Danie, Snoep, Jacky L.
Format:	Artikel
Sprache:	eng
Schlagworte:	glucose transport glycolysis malaria mathematical modelling red blood cell systems biology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!