Supraphysiological Androgens Promote the Tumor Suppressive Activity of the Androgen Receptor through cMYC Repression and Recruitment of the DREAM Complex

The androgen receptor (AR) pathway regulates key cell survival programs in prostate epithelium. The AR represents a near-universal driver and therapeutic vulnerability in metastatic prostate cancer, and targeting AR has a remarkable therapeutic index. Though most approaches directed toward AR focus...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2023-09, Vol.83 (17), p.2938-2951
Hauptverfasser:	Nyquist, Michael D, Coleman, Ilsa M, Lucas, Jared M, Li, Dapei, Hanratty, Brian, Meade, Hannah, Mostaghel, Elahe A, Plymate, Stephen R, Corey, Eva, Haffner, Michael C, Nelson, Peter S
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens - metabolism Cell Line, Tumor Humans Male Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Receptors, Androgen - genetics Receptors, Androgen - metabolism Signal Transduction Translational Cancer Biology
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