Are the Associations between Life-style Related Factors and Plasma Total Homocysteine Concentration Different According to Polymorphism of 5, 10-Methylenetetrahydrofolate Reductase Gene(C677T MTHFR)?: A Cross-sectional Study in a Japanese Rural Population
Mild hyperhomocysteinemia is one of the known strong risk factors for atherosclerotic diseases, and therefore it is important to clarify factors that could determine plasma total homocysteine(tHcy)level.A cross-sectional study with a random sample of 455 Japanese rural residents aged 40-69 years was...
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| Veröffentlicht in: | Journal of Epidemiology 2002, Vol.12(2), pp.126-135 |
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| creator | Lwin, Htay Yokoyama, Tetsuji Date, Chigusa Yoshiike, Nobuo Kokubo, Yoshihiro Tanaka, Heizo |
| description | Mild hyperhomocysteinemia is one of the known strong risk factors for atherosclerotic diseases, and therefore it is important to clarify factors that could determine plasma total homocysteine(tHcy)level.A cross-sectional study with a random sample of 455 Japanese rural residents aged 40-69 years was conducted in 2000 to investigate the associations of plasma tHcy concentration with 5, 10-methylenetetrahydrofolate reductase(MTHFR)gene and selected life-style related factors.The frequency of the mutant allele, Valine(V)allele, was 0.40 and the prevalence of W genotype was 14.3 %.Plasma tHcy concentration in W was significantly higher than those in two other genotypes.There were significant inverse associations of plasma tHcy with serum folate and serum vitamin B12(P |
| doi_str_mv | 10.2188/jea.12.126 |
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Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Lwin, Htay ; Yokoyama, Tetsuji ; Date, Chigusa ; Yoshiike, Nobuo ; Kokubo, Yoshihiro ; Tanaka, Heizo</creator><creatorcontrib>Lwin, Htay ; Yokoyama, Tetsuji ; Date, Chigusa ; Yoshiike, Nobuo ; Kokubo, Yoshihiro ; Tanaka, Heizo</creatorcontrib><description>Mild hyperhomocysteinemia is one of the known strong risk factors for atherosclerotic diseases, and therefore it is important to clarify factors that could determine plasma total homocysteine(tHcy)level.A cross-sectional study with a random sample of 455 Japanese rural residents aged 40-69 years was conducted in 2000 to investigate the associations of plasma tHcy concentration with 5, 10-methylenetetrahydrofolate reductase(MTHFR)gene and selected life-style related factors.The frequency of the mutant allele, Valine(V)allele, was 0.40 and the prevalence of W genotype was 14.3 %.Plasma tHcy concentration in W was significantly higher than those in two other genotypes.There were significant inverse associations of plasma tHcy with serum folate and serum vitamin B12(P<0.001 for trend, respectively);both being stronger in W than in other genotypes.The number of cigarettes smoked per day was positively associated with plasma tHcy concentration.A multivariate regression analysis revealed that serum folate, serum vitamin B12, and MTHFR genotype were independently associated with plasma tHcy.The inter-individual variance of plasma tHcy was more explained by serum folate and vitamin B12 than by MTHFR genotype.Higher intakes of folate, vitamin B12, and non-smoking may be important to prevent mild hyperhomocysteinemia and the eventual atherosclerotic diseases in this Japanese rural population.J Epidemiol, 2002;12:126-135</description><identifier>ISSN: 0917-5040</identifier><identifier>EISSN: 1349-9092</identifier><identifier>DOI: 10.2188/jea.12.126</identifier><identifier>PMID: 12033523</identifier><language>eng</language><publisher>Japan: Japan Epidemiological Association</publisher><subject>Alleles ; Analysis of Variance ; Chi-Square Distribution ; Cross-Sectional Studies ; Female ; Genotype ; homocysteine ; Homocysteine - blood ; Humans ; Japan - epidemiology ; Japanese ; Life Style ; Male ; MTHFR ; Original ; Oxidoreductases Acting on CH-NH Group Donors - genetics ; Polymorphism, Genetic ; Regression Analysis ; Risk Factors ; Rural Population ; serum folate and vitamin B12 ; smoking ; Surveys and Questionnaires</subject><ispartof>Journal of Epidemiology, 2002, Vol.12(2), pp.126-135</ispartof><rights>Japan Epidemiological Association</rights><rights>2002 Japan Epidemiological Association. 2002 Japan Epidemiological Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4406-439847c8e7be665b1ddd86de0c4a19d83c0e71981dda556c933281b466fc833c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468345/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468345/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,1884,4025,27927,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12033523$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lwin, Htay</creatorcontrib><creatorcontrib>Yokoyama, Tetsuji</creatorcontrib><creatorcontrib>Date, Chigusa</creatorcontrib><creatorcontrib>Yoshiike, Nobuo</creatorcontrib><creatorcontrib>Kokubo, Yoshihiro</creatorcontrib><creatorcontrib>Tanaka, Heizo</creatorcontrib><title>Are the Associations between Life-style Related Factors and Plasma Total Homocysteine Concentration Different According to Polymorphism of 5, 10-Methylenetetrahydrofolate Reductase Gene(C677T MTHFR)?: A Cross-sectional Study in a Japanese Rural Population</title><title>Journal of Epidemiology</title><addtitle>Journal of Epidemiology</addtitle><description>Mild hyperhomocysteinemia is one of the known strong risk factors for atherosclerotic diseases, and therefore it is important to clarify factors that could determine plasma total homocysteine(tHcy)level.A cross-sectional study with a random sample of 455 Japanese rural residents aged 40-69 years was conducted in 2000 to investigate the associations of plasma tHcy concentration with 5, 10-methylenetetrahydrofolate reductase(MTHFR)gene and selected life-style related factors.The frequency of the mutant allele, Valine(V)allele, was 0.40 and the prevalence of W genotype was 14.3 %.Plasma tHcy concentration in W was significantly higher than those in two other genotypes.There were significant inverse associations of plasma tHcy with serum folate and serum vitamin B12(P<0.001 for trend, respectively);both being stronger in W than in other genotypes.The number of cigarettes smoked per day was positively associated with plasma tHcy concentration.A multivariate regression analysis revealed that serum folate, serum vitamin B12, and MTHFR genotype were independently associated with plasma tHcy.The inter-individual variance of plasma tHcy was more explained by serum folate and vitamin B12 than by MTHFR genotype.Higher intakes of folate, vitamin B12, and non-smoking may be important to prevent mild hyperhomocysteinemia and the eventual atherosclerotic diseases in this Japanese rural population.J Epidemiol, 2002;12:126-135</description><subject>Alleles</subject><subject>Analysis of Variance</subject><subject>Chi-Square Distribution</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Genotype</subject><subject>homocysteine</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Japanese</subject><subject>Life Style</subject><subject>Male</subject><subject>MTHFR</subject><subject>Original</subject><subject>Oxidoreductases Acting on CH-NH Group Donors - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Regression Analysis</subject><subject>Risk Factors</subject><subject>Rural Population</subject><subject>serum folate and vitamin B12</subject><subject>smoking</subject><subject>Surveys and Questionnaires</subject><issn>0917-5040</issn><issn>1349-9092</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkdGOEyEUhidG43ZXb3wAw5VxjbPCMMMwV5tmtFuTbtxs6jWhcKZDMwMVqKZP6GtJba2anEDgfPz_IX-WvSL4piCcf9iAvCFFKvYkmxBaNnmDm-JpNsENqfMKl_giuwxhgzFlvMDPswtSYEqrgk6yn1MPKPaApiE4ZWQ0zga0gvgDwKKF6SAPcT8AeoRBRtBoJlV0PiBpNXoYZBglWrooBzR3o1P7EMFYQK2zCmz0v_XQR9N14NMZTZVyXhu7RtGhBzfsR-e3vQkjch2q3iOC83uIfTK0ECG97_fau84dvNMIeqeiDIDuUvtty-p6ie6X89nj9e2L7FknhwAvT_tV9nX2adnO88WXu8_tdJGrssQsL2nDy1pxqFfAWLUiWmvONGBVStJoThWGmjQ83cuqYqqhtOBkVTLWKU6polfZ7VF3u1uNoI-fHMTWm1H6vXDSiP871vRi7b4LgkvGaVklhTcnBe--7SBEMZqgYBikBbcLoiaHAWiRwHdHUHkXgofu7EKwOAQvUvCCFKlYgl__O9df9JR0AtojsAlRruEMSB-NGuCgRZqGHPSKPws7d1UvvQBLfwEkusSS</recordid><startdate>2002</startdate><enddate>2002</enddate><creator>Lwin, Htay</creator><creator>Yokoyama, Tetsuji</creator><creator>Date, Chigusa</creator><creator>Yoshiike, Nobuo</creator><creator>Kokubo, Yoshihiro</creator><creator>Tanaka, Heizo</creator><general>Japan Epidemiological Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2002</creationdate><title>Are the Associations between Life-style Related Factors and Plasma Total Homocysteine Concentration Different According to Polymorphism of 5, 10-Methylenetetrahydrofolate Reductase Gene(C677T MTHFR)?</title><author>Lwin, Htay ; Yokoyama, Tetsuji ; Date, Chigusa ; Yoshiike, Nobuo ; Kokubo, Yoshihiro ; Tanaka, Heizo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4406-439847c8e7be665b1ddd86de0c4a19d83c0e71981dda556c933281b466fc833c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Alleles</topic><topic>Analysis of Variance</topic><topic>Chi-Square Distribution</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Genotype</topic><topic>homocysteine</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Japanese</topic><topic>Life Style</topic><topic>Male</topic><topic>MTHFR</topic><topic>Original</topic><topic>Oxidoreductases Acting on CH-NH Group Donors - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Regression Analysis</topic><topic>Risk Factors</topic><topic>Rural Population</topic><topic>serum folate and vitamin B12</topic><topic>smoking</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lwin, Htay</creatorcontrib><creatorcontrib>Yokoyama, Tetsuji</creatorcontrib><creatorcontrib>Date, Chigusa</creatorcontrib><creatorcontrib>Yoshiike, Nobuo</creatorcontrib><creatorcontrib>Kokubo, Yoshihiro</creatorcontrib><creatorcontrib>Tanaka, Heizo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lwin, Htay</au><au>Yokoyama, Tetsuji</au><au>Date, Chigusa</au><au>Yoshiike, Nobuo</au><au>Kokubo, Yoshihiro</au><au>Tanaka, Heizo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Are the Associations between Life-style Related Factors and Plasma Total Homocysteine Concentration Different According to Polymorphism of 5, 10-Methylenetetrahydrofolate Reductase Gene(C677T MTHFR)?: A Cross-sectional Study in a Japanese Rural Population</atitle><jtitle>Journal of Epidemiology</jtitle><addtitle>Journal of Epidemiology</addtitle><date>2002</date><risdate>2002</risdate><volume>12</volume><issue>2</issue><spage>126</spage><epage>135</epage><pages>126-135</pages><issn>0917-5040</issn><eissn>1349-9092</eissn><abstract>Mild hyperhomocysteinemia is one of the known strong risk factors for atherosclerotic diseases, and therefore it is important to clarify factors that could determine plasma total homocysteine(tHcy)level.A cross-sectional study with a random sample of 455 Japanese rural residents aged 40-69 years was conducted in 2000 to investigate the associations of plasma tHcy concentration with 5, 10-methylenetetrahydrofolate reductase(MTHFR)gene and selected life-style related factors.The frequency of the mutant allele, Valine(V)allele, was 0.40 and the prevalence of W genotype was 14.3 %.Plasma tHcy concentration in W was significantly higher than those in two other genotypes.There were significant inverse associations of plasma tHcy with serum folate and serum vitamin B12(P<0.001 for trend, respectively);both being stronger in W than in other genotypes.The number of cigarettes smoked per day was positively associated with plasma tHcy concentration.A multivariate regression analysis revealed that serum folate, serum vitamin B12, and MTHFR genotype were independently associated with plasma tHcy.The inter-individual variance of plasma tHcy was more explained by serum folate and vitamin B12 than by MTHFR genotype.Higher intakes of folate, vitamin B12, and non-smoking may be important to prevent mild hyperhomocysteinemia and the eventual atherosclerotic diseases in this Japanese rural population.J Epidemiol, 2002;12:126-135</abstract><cop>Japan</cop><pub>Japan Epidemiological Association</pub><pmid>12033523</pmid><doi>10.2188/jea.12.126</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Alleles Analysis of Variance Chi-Square Distribution Cross-Sectional Studies Female Genotype homocysteine Homocysteine - blood Humans Japan - epidemiology Japanese Life Style Male MTHFR Original Oxidoreductases Acting on CH-NH Group Donors - genetics Polymorphism, Genetic Regression Analysis Risk Factors Rural Population serum folate and vitamin B12 smoking Surveys and Questionnaires |
| title | Are the Associations between Life-style Related Factors and Plasma Total Homocysteine Concentration Different According to Polymorphism of 5, 10-Methylenetetrahydrofolate Reductase Gene(C677T MTHFR)?: A Cross-sectional Study in a Japanese Rural Population |
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