Using Drosophila to identify naturally occurring genetic modifiers of amyloid beta 42- and tau-induced toxicity

Abstract Alzheimer's disease is characterized by 2 pathological proteins, amyloid beta 42 and tau. The majority of Alzheimer's disease cases in the population are sporadic and late-onset Alzheimer's disease, which exhibits high levels of heritability. While several genetic risk factor...

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Veröffentlicht in:	G3 : genes - genomes - genetics 2023-08, Vol.13 (9)
Hauptverfasser:	Yang, Ming, Zinkgraf, Matthew, Fitzgerald-Cook, Cecilia, Harrison, Benjamin R, Putzier, Alexandra, Promislow, Daniel E L, Wang, Adrienne M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer's disease Amyloid beta-Peptides - genetics Animals Apolipoproteins Drosophila Drosophila - genetics Drosophila - metabolism Genetic research Genetic screening Genomics Humans Investigation Medical research Medicine, Experimental Risk factors tau Proteins - genetics tau Proteins - metabolism
Online-Zugang:	Volltext
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