TERT accelerates BRAF mutant-induced thyroid cancer dedifferentiation and progression by regulating ribosome biogenesis

TERT reactivation occurs frequently in human malignancies, especially advanced cancers. However, in vivo functions of TERT reactivation in cancer progression and the underlying mechanism are not fully understood. In this study, we expressed TERT and/or active BRAF ( V600E) specifically in mouse thyr...

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Veröffentlicht in:	Science advances 2023-09, Vol.9 (35), p.eadg7125
Hauptverfasser:	Yu, Pengcheng, Qu, Ning, Zhu, Rui, Hu, Jiaqian, Han, Peizhen, Wu, Jiahao, Tan, Licheng, Gan, Hualei, He, Cong, Fang, Chuantao, Lei, Yubin, Li, Jian, He, Chenxi, Lan, Fei, Shi, Xiao, Wei, Wenjun, Wang, Yu, Ji, Qinghai, Yu, Fa-Xing, Wang, Yu-Long
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Animals Biomedicine and Life Sciences Cancer Cell Dedifferentiation - genetics Humans Life Sciences Mice Proto-Oncogene Proteins B-raf - genetics Ribosomes - genetics RNA, Ribosomal SciAdv r-articles Telomerase - genetics Thyroid Neoplasms - genetics
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