Cancer-specific apoptosis induction in canine lymphoma cell lines by the endocytosis inhibitor dynasore

Canine lymphoma is the most common cancer in dogs and has a poor prognosis. We recently found that the endocytosis inhibitor dynasore suppresses the viability of human cancer cell lines, especially hematopoietic cancers, by inducing apoptosis. In the present study, we examined the anticancer effects...

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Veröffentlicht in:	Journal of Veterinary Medical Science 2023, Vol.85(8), pp.820-827
Hauptverfasser:	SUEMURA, Miki, MIYATA, Haruki, KAWAMURA, Rio, TAKAHASHI, Sho, IGASE, Masaya, MIZUNO, Takuya, OHAMA, Takashi, SHIBUTANI, Shusaku, IWATA, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cancer Cell Line, Tumor Cell viability DNA damage dog Dog Diseases - genetics Dogs dynamin Endocytosis Genotoxicity Humans Leukocytes (mononuclear) Leukocytes, Mononuclear - metabolism Lymphoma Lymphoma - drug therapy Lymphoma - genetics Lymphoma - veterinary mechanistic/mammalian target of rapamycin complex 1 (mTORC1) Peripheral blood mononuclear cells Pharmacology Tumor cell lines
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