Serum folate levels in children on long-term anti-seizure medication in a Nigerian tertiary center—Implications for practice and public health
Background: Epilepsy is the most common childhood neurological disorder in Nigeria. Treatment of epilepsy is long-term and sometimes lifelong with anti-seizure medications. There are conflicting reports on the effect of anti-seizure medications on serum folate. There is therefore a need to determine...
Gespeichert in:
| Veröffentlicht in: | Science progress (1916) 2021-10, Vol.104 (4), p.1-12 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 12 |
|---|---|
| container_issue | 4 |
| container_start_page | 1 |
| container_title | Science progress (1916) |
| container_volume | 104 |
| creator | Bisi-Onyemaechi, Adaobi I Chikani, Ugo N Uwaezuoke, Ndubuisi A Aronu, Ann E Ojinnaka, Ngozi C |
| description | Background:
Epilepsy is the most common childhood neurological disorder in Nigeria. Treatment of epilepsy is long-term and sometimes lifelong with anti-seizure medications. There are conflicting reports on the effect of anti-seizure medications on serum folate. There is therefore a need to determine the effect of a commonly used anti-seizure medication's on serum folate levels of children. This would provide an evidence-based consideration for folic acid supplementation in children on anti-seizure medication as has been suggested by some studies.
Study objectives:
To determine whether serum folate levels were lower in children taking long-term carbamazepine or sodium valproate, compared to a control group.
Methods:
Serum folic acid levels were measured from well-nourished children between the ages of 1–17 years on carbamazepine and sodium valproate monotherapy and their age/sex-matched controls, using spectrophotometry.
Results:
The mean serum folate levels of patients on carbamazepine (43) and sodium valproate (22) were 0.032 mg/l ± 0.009 and 0.028 mg/l ± 0.008, respectively. The mean folate levels of the controls were 0.046 mg/l ± 0.03 (p = 0 001). No statistically significant difference was observed between the serum folate levels of children on the two anti-seizure medications, that is, carbamazepine and valproate.
Conclusion:
The children on treatment with carbamazepine and sodium valproate for more than 6 months had statistically significantly lower serum levels of folic acid compared to the standard reference range and controls. The serum folate levels of children on carbamazepine were not statistically different from those on sodium valproate. |
| doi_str_mv | 10.1177/00368504211057680 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10461376</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>27157710</jstor_id><sage_id>10.1177_00368504211057680</sage_id><sourcerecordid>27157710</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-8f3900bde36f53258ccba03e1235815d050cbefe0d091863029689c20c88758a3</originalsourceid><addsrcrecordid>eNp9kc2O0zAQxy0EYkvhATiALHHhkmUmTmznhFYrPlZawQE4R64zaV05SbGdleDEI3DgCXkSXLWUL4mTLc3v_5sZDWMPEc4RlXoGIKSuoSoRoVZSwy22KKFShUIpbrPFvl7sgTN2L8YtANYo9V12JiqNUulywb6-ozAPvJ-8ScQ93ZCP3I3cbpzvAo18GrmfxnWRKAzcjMkVkdznORAfqHPWJJeJHDD8jVtTcGbkGU3OhE_c0pj_3798uxp2_sjG3CvwXTA2OUvZ2PHdvMpVviHj0-Y-u9MbH-nB8V2yDy9fvL98XVy_fXV1eXFd2KrCVOheNACrjoTsa1HW2tqVAUFYilpj3UENdkU9QQcNaimgbKRubAlWa1VrI5bs-cGbu-dN9qMG49tdcEMevZ2Ma_-sjG7TrqebFqGSKJTMhqdHQ5g-zhRTO7hoyXsz0jTHtpSAjVIa9uiTv9DtNIcx75cpLGUDOjuXDA-UDVOMgfrTNAjt_uDtPwfPmce_r3FK_LxwBs4PQDRr-tX2f8ZHh8A2pimchKXCWikE8QNgeb-H</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2612690861</pqid></control><display><type>article</type><title>Serum folate levels in children on long-term anti-seizure medication in a Nigerian tertiary center—Implications for practice and public health</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Sage Journals GOLD Open Access 2024</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Bisi-Onyemaechi, Adaobi I ; Chikani, Ugo N ; Uwaezuoke, Ndubuisi A ; Aronu, Ann E ; Ojinnaka, Ngozi C</creator><creatorcontrib>Bisi-Onyemaechi, Adaobi I ; Chikani, Ugo N ; Uwaezuoke, Ndubuisi A ; Aronu, Ann E ; Ojinnaka, Ngozi C</creatorcontrib><description>Background:
Epilepsy is the most common childhood neurological disorder in Nigeria. Treatment of epilepsy is long-term and sometimes lifelong with anti-seizure medications. There are conflicting reports on the effect of anti-seizure medications on serum folate. There is therefore a need to determine the effect of a commonly used anti-seizure medication's on serum folate levels of children. This would provide an evidence-based consideration for folic acid supplementation in children on anti-seizure medication as has been suggested by some studies.
Study objectives:
To determine whether serum folate levels were lower in children taking long-term carbamazepine or sodium valproate, compared to a control group.
Methods:
Serum folic acid levels were measured from well-nourished children between the ages of 1–17 years on carbamazepine and sodium valproate monotherapy and their age/sex-matched controls, using spectrophotometry.
Results:
The mean serum folate levels of patients on carbamazepine (43) and sodium valproate (22) were 0.032 mg/l ± 0.009 and 0.028 mg/l ± 0.008, respectively. The mean folate levels of the controls were 0.046 mg/l ± 0.03 (p = 0 001). No statistically significant difference was observed between the serum folate levels of children on the two anti-seizure medications, that is, carbamazepine and valproate.
Conclusion:
The children on treatment with carbamazepine and sodium valproate for more than 6 months had statistically significantly lower serum levels of folic acid compared to the standard reference range and controls. The serum folate levels of children on carbamazepine were not statistically different from those on sodium valproate.</description><identifier>ISSN: 0036-8504</identifier><identifier>EISSN: 2047-7163</identifier><identifier>DOI: 10.1177/00368504211057680</identifier><identifier>PMID: 34816782</identifier><language>eng</language><publisher>London, England: Sage Publications, Ltd</publisher><subject>Adolescent ; Anticonvulsants - therapeutic use ; Carbamazepine ; Carbamazepine - therapeutic use ; Child ; Child, Preschool ; Children ; Convulsions & seizures ; Epilepsy ; Epilepsy - drug therapy ; Erythrocytes ; Folic acid ; Folic Acid - therapeutic use ; Humans ; Infant ; Neurological diseases ; Nigeria - epidemiology ; Original Manuscript ; Public Health ; Seizures ; Serum levels ; Sodium ; Sodium valproate ; Spectrophotometry ; Statistical analysis ; Supplements ; Valproic acid ; Valproic Acid - therapeutic use ; Vitamin B</subject><ispartof>Science progress (1916), 2021-10, Vol.104 (4), p.1-12</ispartof><rights>The Author(s) 2021</rights><rights>2021. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( https://creativecommons.org/licenses/by-nc/4.0/ ) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page ( https://us.sagepub.com/en-us/nam/open-access-at-sage ). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2021 2021 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c441t-8f3900bde36f53258ccba03e1235815d050cbefe0d091863029689c20c88758a3</cites><orcidid>0000-0001-8416-6312</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461376/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461376/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,21964,27851,27922,27923,44943,45331,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34816782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bisi-Onyemaechi, Adaobi I</creatorcontrib><creatorcontrib>Chikani, Ugo N</creatorcontrib><creatorcontrib>Uwaezuoke, Ndubuisi A</creatorcontrib><creatorcontrib>Aronu, Ann E</creatorcontrib><creatorcontrib>Ojinnaka, Ngozi C</creatorcontrib><title>Serum folate levels in children on long-term anti-seizure medication in a Nigerian tertiary center—Implications for practice and public health</title><title>Science progress (1916)</title><addtitle>Sci Prog</addtitle><description>Background:
Epilepsy is the most common childhood neurological disorder in Nigeria. Treatment of epilepsy is long-term and sometimes lifelong with anti-seizure medications. There are conflicting reports on the effect of anti-seizure medications on serum folate. There is therefore a need to determine the effect of a commonly used anti-seizure medication's on serum folate levels of children. This would provide an evidence-based consideration for folic acid supplementation in children on anti-seizure medication as has been suggested by some studies.
Study objectives:
To determine whether serum folate levels were lower in children taking long-term carbamazepine or sodium valproate, compared to a control group.
Methods:
Serum folic acid levels were measured from well-nourished children between the ages of 1–17 years on carbamazepine and sodium valproate monotherapy and their age/sex-matched controls, using spectrophotometry.
Results:
The mean serum folate levels of patients on carbamazepine (43) and sodium valproate (22) were 0.032 mg/l ± 0.009 and 0.028 mg/l ± 0.008, respectively. The mean folate levels of the controls were 0.046 mg/l ± 0.03 (p = 0 001). No statistically significant difference was observed between the serum folate levels of children on the two anti-seizure medications, that is, carbamazepine and valproate.
Conclusion:
The children on treatment with carbamazepine and sodium valproate for more than 6 months had statistically significantly lower serum levels of folic acid compared to the standard reference range and controls. The serum folate levels of children on carbamazepine were not statistically different from those on sodium valproate.</description><subject>Adolescent</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Carbamazepine</subject><subject>Carbamazepine - therapeutic use</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Convulsions & seizures</subject><subject>Epilepsy</subject><subject>Epilepsy - drug therapy</subject><subject>Erythrocytes</subject><subject>Folic acid</subject><subject>Folic Acid - therapeutic use</subject><subject>Humans</subject><subject>Infant</subject><subject>Neurological diseases</subject><subject>Nigeria - epidemiology</subject><subject>Original Manuscript</subject><subject>Public Health</subject><subject>Seizures</subject><subject>Serum levels</subject><subject>Sodium</subject><subject>Sodium valproate</subject><subject>Spectrophotometry</subject><subject>Statistical analysis</subject><subject>Supplements</subject><subject>Valproic acid</subject><subject>Valproic Acid - therapeutic use</subject><subject>Vitamin B</subject><issn>0036-8504</issn><issn>2047-7163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><recordid>eNp9kc2O0zAQxy0EYkvhATiALHHhkmUmTmznhFYrPlZawQE4R64zaV05SbGdleDEI3DgCXkSXLWUL4mTLc3v_5sZDWMPEc4RlXoGIKSuoSoRoVZSwy22KKFShUIpbrPFvl7sgTN2L8YtANYo9V12JiqNUulywb6-ozAPvJ-8ScQ93ZCP3I3cbpzvAo18GrmfxnWRKAzcjMkVkdznORAfqHPWJJeJHDD8jVtTcGbkGU3OhE_c0pj_3798uxp2_sjG3CvwXTA2OUvZ2PHdvMpVviHj0-Y-u9MbH-nB8V2yDy9fvL98XVy_fXV1eXFd2KrCVOheNACrjoTsa1HW2tqVAUFYilpj3UENdkU9QQcNaimgbKRubAlWa1VrI5bs-cGbu-dN9qMG49tdcEMevZ2Ma_-sjG7TrqebFqGSKJTMhqdHQ5g-zhRTO7hoyXsz0jTHtpSAjVIa9uiTv9DtNIcx75cpLGUDOjuXDA-UDVOMgfrTNAjt_uDtPwfPmce_r3FK_LxwBs4PQDRr-tX2f8ZHh8A2pimchKXCWikE8QNgeb-H</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Bisi-Onyemaechi, Adaobi I</creator><creator>Chikani, Ugo N</creator><creator>Uwaezuoke, Ndubuisi A</creator><creator>Aronu, Ann E</creator><creator>Ojinnaka, Ngozi C</creator><general>Sage Publications, Ltd</general><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JQ2</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8416-6312</orcidid></search><sort><creationdate>20211001</creationdate><title>Serum folate levels in children on long-term anti-seizure medication in a Nigerian tertiary center—Implications for practice and public health</title><author>Bisi-Onyemaechi, Adaobi I ; Chikani, Ugo N ; Uwaezuoke, Ndubuisi A ; Aronu, Ann E ; Ojinnaka, Ngozi C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-8f3900bde36f53258ccba03e1235815d050cbefe0d091863029689c20c88758a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Carbamazepine</topic><topic>Carbamazepine - therapeutic use</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Convulsions & seizures</topic><topic>Epilepsy</topic><topic>Epilepsy - drug therapy</topic><topic>Erythrocytes</topic><topic>Folic acid</topic><topic>Folic Acid - therapeutic use</topic><topic>Humans</topic><topic>Infant</topic><topic>Neurological diseases</topic><topic>Nigeria - epidemiology</topic><topic>Original Manuscript</topic><topic>Public Health</topic><topic>Seizures</topic><topic>Serum levels</topic><topic>Sodium</topic><topic>Sodium valproate</topic><topic>Spectrophotometry</topic><topic>Statistical analysis</topic><topic>Supplements</topic><topic>Valproic acid</topic><topic>Valproic Acid - therapeutic use</topic><topic>Vitamin B</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bisi-Onyemaechi, Adaobi I</creatorcontrib><creatorcontrib>Chikani, Ugo N</creatorcontrib><creatorcontrib>Uwaezuoke, Ndubuisi A</creatorcontrib><creatorcontrib>Aronu, Ann E</creatorcontrib><creatorcontrib>Ojinnaka, Ngozi C</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science progress (1916)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bisi-Onyemaechi, Adaobi I</au><au>Chikani, Ugo N</au><au>Uwaezuoke, Ndubuisi A</au><au>Aronu, Ann E</au><au>Ojinnaka, Ngozi C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum folate levels in children on long-term anti-seizure medication in a Nigerian tertiary center—Implications for practice and public health</atitle><jtitle>Science progress (1916)</jtitle><addtitle>Sci Prog</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>104</volume><issue>4</issue><spage>1</spage><epage>12</epage><pages>1-12</pages><issn>0036-8504</issn><eissn>2047-7163</eissn><abstract>Background:
Epilepsy is the most common childhood neurological disorder in Nigeria. Treatment of epilepsy is long-term and sometimes lifelong with anti-seizure medications. There are conflicting reports on the effect of anti-seizure medications on serum folate. There is therefore a need to determine the effect of a commonly used anti-seizure medication's on serum folate levels of children. This would provide an evidence-based consideration for folic acid supplementation in children on anti-seizure medication as has been suggested by some studies.
Study objectives:
To determine whether serum folate levels were lower in children taking long-term carbamazepine or sodium valproate, compared to a control group.
Methods:
Serum folic acid levels were measured from well-nourished children between the ages of 1–17 years on carbamazepine and sodium valproate monotherapy and their age/sex-matched controls, using spectrophotometry.
Results:
The mean serum folate levels of patients on carbamazepine (43) and sodium valproate (22) were 0.032 mg/l ± 0.009 and 0.028 mg/l ± 0.008, respectively. The mean folate levels of the controls were 0.046 mg/l ± 0.03 (p = 0 001). No statistically significant difference was observed between the serum folate levels of children on the two anti-seizure medications, that is, carbamazepine and valproate.
Conclusion:
The children on treatment with carbamazepine and sodium valproate for more than 6 months had statistically significantly lower serum levels of folic acid compared to the standard reference range and controls. The serum folate levels of children on carbamazepine were not statistically different from those on sodium valproate.</abstract><cop>London, England</cop><pub>Sage Publications, Ltd</pub><pmid>34816782</pmid><doi>10.1177/00368504211057680</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-8416-6312</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8504 |
| ispartof | Science progress (1916), 2021-10, Vol.104 (4), p.1-12 |
| issn | 0036-8504 2047-7163 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10461376 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Sage Journals GOLD Open Access 2024; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Anticonvulsants - therapeutic use Carbamazepine Carbamazepine - therapeutic use Child Child, Preschool Children Convulsions & seizures Epilepsy Epilepsy - drug therapy Erythrocytes Folic acid Folic Acid - therapeutic use Humans Infant Neurological diseases Nigeria - epidemiology Original Manuscript Public Health Seizures Serum levels Sodium Sodium valproate Spectrophotometry Statistical analysis Supplements Valproic acid Valproic Acid - therapeutic use Vitamin B |
| title | Serum folate levels in children on long-term anti-seizure medication in a Nigerian tertiary center—Implications for practice and public health |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T14%3A11%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serum%20folate%20levels%20in%20children%20on%20long-term%20anti-seizure%20medication%20in%20a%20Nigerian%20tertiary%20center%E2%80%94Implications%20for%20practice%20and%20public%20health&rft.jtitle=Science%20progress%20(1916)&rft.au=Bisi-Onyemaechi,%20Adaobi%20I&rft.date=2021-10-01&rft.volume=104&rft.issue=4&rft.spage=1&rft.epage=12&rft.pages=1-12&rft.issn=0036-8504&rft.eissn=2047-7163&rft_id=info:doi/10.1177/00368504211057680&rft_dat=%3Cjstor_pubme%3E27157710%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2612690861&rft_id=info:pmid/34816782&rft_jstor_id=27157710&rft_sage_id=10.1177_00368504211057680&rfr_iscdi=true |