Understanding the Vicious Circle of Pain, Physical Activity, and Mental Health in Lipedema Patients—A Response Surface Analysis
Lipedema is a widespread disease with painful accumulations of subcutaneous fat in the legs and arms. Often, obesity co-occurs. Many patients suffer from impairment in mobility and mental health. Obesity and mental health in turn can be positively influenced by physical activity. In this study, we a...
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| Veröffentlicht in: | Journal of clinical medicine 2023-08, Vol.12 (16), p.5319 |
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| creator | Aitzetmüller-Klietz, Marie-Luise Busch, Lena Hamatschek, Matthias Paul, Matthias Schriek, Carsten Wiebringhaus, Philipp Aitzetmüller-Klietz, Matthias Kückelhaus, Maximilian Hirsch, Tobias |
| description | Lipedema is a widespread disease with painful accumulations of subcutaneous fat in the legs and arms. Often, obesity co-occurs. Many patients suffer from impairment in mobility and mental health. Obesity and mental health in turn can be positively influenced by physical activity. In this study, we aimed to examine the interrelations between pain and physical activity on mental health in lipedema patients. In total, 511 female lipedema patients (age M = 40.16 ± 12.45 years, BMI M = 33.86 ± 7.80 kg/m2) filled in questionnaires measuring pain, physical activity, and mental health (PHQ-9; WHOQOL-BREF with subscales mental, physical, social, environmental, and overall health). Response surface analyses were calculated via R statistics. The explained variance was high for the model predicting depression severity (R2 = 0.18, p < 0.001) and physical health (R2 = 0.30, p < 0.001). Additive incongruence effects of pain and physical activity on depression severity, mental, physical, and overall health were found (all p < 0.001). In our study, physical activity and pain synergistically influenced physical, mental, and overall health. The pain not only led to low mental health but also interfered with the valuable potential of engaging in physical activity in lipedema patients. |
| doi_str_mv | 10.3390/jcm12165319 |
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Often, obesity co-occurs. Many patients suffer from impairment in mobility and mental health. Obesity and mental health in turn can be positively influenced by physical activity. In this study, we aimed to examine the interrelations between pain and physical activity on mental health in lipedema patients. In total, 511 female lipedema patients (age M = 40.16 ± 12.45 years, BMI M = 33.86 ± 7.80 kg/m2) filled in questionnaires measuring pain, physical activity, and mental health (PHQ-9; WHOQOL-BREF with subscales mental, physical, social, environmental, and overall health). Response surface analyses were calculated via R statistics. The explained variance was high for the model predicting depression severity (R2 = 0.18, p < 0.001) and physical health (R2 = 0.30, p < 0.001). Additive incongruence effects of pain and physical activity on depression severity, mental, physical, and overall health were found (all p < 0.001). In our study, physical activity and pain synergistically influenced physical, mental, and overall health. The pain not only led to low mental health but also interfered with the valuable potential of engaging in physical activity in lipedema patients.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm12165319</identifier><identifier>PMID: 37629361</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Chronic pain ; Clinical medicine ; Complications and side effects ; Depression, Mental ; Disease ; Exercise ; Family medical history ; Gastrointestinal surgery ; Health aspects ; Hypotheses ; Liposuction ; Lymphedema ; Mental depression ; Mental health ; Pain ; Physical fitness ; Psychological aspects ; Quality of life ; Questionnaires ; Risk factors ; Variables ; Weight control</subject><ispartof>Journal of clinical medicine, 2023-08, Vol.12 (16), p.5319</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Often, obesity co-occurs. Many patients suffer from impairment in mobility and mental health. Obesity and mental health in turn can be positively influenced by physical activity. In this study, we aimed to examine the interrelations between pain and physical activity on mental health in lipedema patients. In total, 511 female lipedema patients (age M = 40.16 ± 12.45 years, BMI M = 33.86 ± 7.80 kg/m2) filled in questionnaires measuring pain, physical activity, and mental health (PHQ-9; WHOQOL-BREF with subscales mental, physical, social, environmental, and overall health). Response surface analyses were calculated via R statistics. The explained variance was high for the model predicting depression severity (R2 = 0.18, p < 0.001) and physical health (R2 = 0.30, p < 0.001). Additive incongruence effects of pain and physical activity on depression severity, mental, physical, and overall health were found (all p < 0.001). In our study, physical activity and pain synergistically influenced physical, mental, and overall health. The pain not only led to low mental health but also interfered with the valuable potential of engaging in physical activity in lipedema patients.</description><subject>Chronic pain</subject><subject>Clinical medicine</subject><subject>Complications and side effects</subject><subject>Depression, Mental</subject><subject>Disease</subject><subject>Exercise</subject><subject>Family medical history</subject><subject>Gastrointestinal surgery</subject><subject>Health aspects</subject><subject>Hypotheses</subject><subject>Liposuction</subject><subject>Lymphedema</subject><subject>Mental depression</subject><subject>Mental health</subject><subject>Pain</subject><subject>Physical fitness</subject><subject>Psychological aspects</subject><subject>Quality of life</subject><subject>Questionnaires</subject><subject>Risk factors</subject><subject>Variables</subject><subject>Weight control</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptks1q3DAQx01paUKaU19A0Euh2URftuxTMUuaBDY0tE2vQpZGu1psaSvZgb0179An7JNEy4aQlEoHiZnf_KX5KIr3BJ8y1uCztR4IJVXJSPOqOKRYiBlmNXv97H5QHKe0xnnVNadEvC0OmKhowypyWNzfegMxjcob55doXAH66bQLU0JzF3UPKFh0o5w_QTerbXJa9ajVo7tz4_YE5Sh0DX7MxktQ_bhCzqOF24CBQeWw0WVn-vv7T4u-QdoEnwB9n6JVGlDrVZ8F07vijVV9guPH86i4_XL-Y345W3y9uJq3i5nmhI4za3TVlLgE3ZlGMU4UZYaDJcRya8pOCdZQaplhtmlo1TWM1hYborTFHeaaHRWf97qbqRvA6PyzqHq5iW5QcSuDcvKlx7uVXIY7STAvy6rkWeHjo0IMvyZIoxxc0tD3ykMumKR1KWrOsCAZ_fAPug5TzBnvqdyaHflELVUP0nkb8sN6Jyrb3CEuRIVFpk7_Q-Wdi-x08GBdtr8I-LQP0DGkFME-JUmw3E2NfDY17AEDi7Qf</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Aitzetmüller-Klietz, Marie-Luise</creator><creator>Busch, Lena</creator><creator>Hamatschek, Matthias</creator><creator>Paul, Matthias</creator><creator>Schriek, Carsten</creator><creator>Wiebringhaus, Philipp</creator><creator>Aitzetmüller-Klietz, Matthias</creator><creator>Kückelhaus, Maximilian</creator><creator>Hirsch, Tobias</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4827-3238</orcidid><orcidid>https://orcid.org/0000-0002-8005-5639</orcidid><orcidid>https://orcid.org/0000-0002-5780-0135</orcidid></search><sort><creationdate>20230801</creationdate><title>Understanding the Vicious Circle of Pain, Physical Activity, and Mental Health in Lipedema Patients—A Response Surface Analysis</title><author>Aitzetmüller-Klietz, Marie-Luise ; 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Often, obesity co-occurs. Many patients suffer from impairment in mobility and mental health. Obesity and mental health in turn can be positively influenced by physical activity. In this study, we aimed to examine the interrelations between pain and physical activity on mental health in lipedema patients. In total, 511 female lipedema patients (age M = 40.16 ± 12.45 years, BMI M = 33.86 ± 7.80 kg/m2) filled in questionnaires measuring pain, physical activity, and mental health (PHQ-9; WHOQOL-BREF with subscales mental, physical, social, environmental, and overall health). Response surface analyses were calculated via R statistics. The explained variance was high for the model predicting depression severity (R2 = 0.18, p < 0.001) and physical health (R2 = 0.30, p < 0.001). Additive incongruence effects of pain and physical activity on depression severity, mental, physical, and overall health were found (all p < 0.001). 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| subjects | Chronic pain Clinical medicine Complications and side effects Depression, Mental Disease Exercise Family medical history Gastrointestinal surgery Health aspects Hypotheses Liposuction Lymphedema Mental depression Mental health Pain Physical fitness Psychological aspects Quality of life Questionnaires Risk factors Variables Weight control |
| title | Understanding the Vicious Circle of Pain, Physical Activity, and Mental Health in Lipedema Patients—A Response Surface Analysis |
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