Change in Androgenic Status and Cardiometabolic Profile of Middle-Aged Women with Polycystic Ovary Syndrome
Understanding the cardiovascular disease (CVD) risk for women with polycystic ovary syndrome (PCOS) at reproductive age is crucial. To investigate this, we compared the cardiometabolic profiles of different PCOS groups over a median interval of 15.8 years. The study focused on three groups: (1) wome...
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| Veröffentlicht in: | Journal of clinical medicine 2023-08, Vol.12 (16), p.5226 |
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| creator | van der Ham, Kim Koster, Maria P. H Velthuis, Birgitta K Budde, Ricardo P. J Fauser, Bart C. J. M Laven, Joop S. E Louwers, Yvonne V |
| description | Understanding the cardiovascular disease (CVD) risk for women with polycystic ovary syndrome (PCOS) at reproductive age is crucial. To investigate this, we compared the cardiometabolic profiles of different PCOS groups over a median interval of 15.8 years. The study focused on three groups: (1) women with PCOS who were hyperandrogenic at both initial and follow-up screening (HA-HA), (2) those who transitioned from hyperandrogenic to normoandrogenic (HA-NA), and (3) those who remained normoandrogenic (NA-NA). At initial and follow-up screenings, both HA-HA and HA-NA groups showed higher body mass indexes compared to the NA-NA group. Additionally, at follow-up, the HA-HA and HA-NA groups exhibited higher blood pressure, a higher prevalence of hypertension, elevated serum triglycerides and insulin levels, and lower levels of HDL cholesterol compared to the NA-NA group. Even after adjusting for BMI, significant differences persisted in HDL cholesterol levels and hypertension prevalence among the groups (HA-HA: 53.8%, HA-NA: 53.1%, NA-NA: 14.3%, p < 0.01). However, calcium scores and the prevalence of coronary plaques on CT scans were similar across all groups. In conclusion, women with PCOS and hyperandrogenism during their reproductive years exhibited an unfavorable cardiometabolic profile during their post-reproductive years, even if they changed to a normoandrogenic status. |
| doi_str_mv | 10.3390/jcm12165226 |
| format | Article |
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H ; Velthuis, Birgitta K ; Budde, Ricardo P. J ; Fauser, Bart C. J. M ; Laven, Joop S. E ; Louwers, Yvonne V</creator><creatorcontrib>van der Ham, Kim ; Koster, Maria P. H ; Velthuis, Birgitta K ; Budde, Ricardo P. J ; Fauser, Bart C. J. M ; Laven, Joop S. E ; Louwers, Yvonne V</creatorcontrib><description>Understanding the cardiovascular disease (CVD) risk for women with polycystic ovary syndrome (PCOS) at reproductive age is crucial. To investigate this, we compared the cardiometabolic profiles of different PCOS groups over a median interval of 15.8 years. The study focused on three groups: (1) women with PCOS who were hyperandrogenic at both initial and follow-up screening (HA-HA), (2) those who transitioned from hyperandrogenic to normoandrogenic (HA-NA), and (3) those who remained normoandrogenic (NA-NA). At initial and follow-up screenings, both HA-HA and HA-NA groups showed higher body mass indexes compared to the NA-NA group. Additionally, at follow-up, the HA-HA and HA-NA groups exhibited higher blood pressure, a higher prevalence of hypertension, elevated serum triglycerides and insulin levels, and lower levels of HDL cholesterol compared to the NA-NA group. Even after adjusting for BMI, significant differences persisted in HDL cholesterol levels and hypertension prevalence among the groups (HA-HA: 53.8%, HA-NA: 53.1%, NA-NA: 14.3%, p < 0.01). However, calcium scores and the prevalence of coronary plaques on CT scans were similar across all groups. In conclusion, women with PCOS and hyperandrogenism during their reproductive years exhibited an unfavorable cardiometabolic profile during their post-reproductive years, even if they changed to a normoandrogenic status.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm12165226</identifier><identifier>PMID: 37629271</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Age ; Androgens ; Atherosclerosis ; Blood pressure ; Calcification ; Cardiovascular disease ; Cardiovascular diseases ; Clinical medicine ; Complications and side effects ; Coronary vessels ; Diabetes ; Diagnosis ; Estrogens ; Gonadal disorders ; Health aspects ; High density lipoprotein ; Housework ; Hypertension ; Menstruation ; Metabolic disorders ; Middle aged women ; Morphology ; Ovaries ; Polycystic ovary syndrome ; Questionnaires ; Risk factors ; Stein-Leventhal syndrome ; Testosterone ; Triglycerides ; Ultrasonic imaging ; Vitamin deficiency ; Womens health</subject><ispartof>Journal of clinical medicine, 2023-08, Vol.12 (16), p.5226</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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At initial and follow-up screenings, both HA-HA and HA-NA groups showed higher body mass indexes compared to the NA-NA group. Additionally, at follow-up, the HA-HA and HA-NA groups exhibited higher blood pressure, a higher prevalence of hypertension, elevated serum triglycerides and insulin levels, and lower levels of HDL cholesterol compared to the NA-NA group. Even after adjusting for BMI, significant differences persisted in HDL cholesterol levels and hypertension prevalence among the groups (HA-HA: 53.8%, HA-NA: 53.1%, NA-NA: 14.3%, p < 0.01). However, calcium scores and the prevalence of coronary plaques on CT scans were similar across all groups. In conclusion, women with PCOS and hyperandrogenism during their reproductive years exhibited an unfavorable cardiometabolic profile during their post-reproductive years, even if they changed to a normoandrogenic status.</description><subject>Age</subject><subject>Androgens</subject><subject>Atherosclerosis</subject><subject>Blood pressure</subject><subject>Calcification</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Clinical medicine</subject><subject>Complications and side effects</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>Diagnosis</subject><subject>Estrogens</subject><subject>Gonadal disorders</subject><subject>Health aspects</subject><subject>High density lipoprotein</subject><subject>Housework</subject><subject>Hypertension</subject><subject>Menstruation</subject><subject>Metabolic disorders</subject><subject>Middle aged women</subject><subject>Morphology</subject><subject>Ovaries</subject><subject>Polycystic ovary syndrome</subject><subject>Questionnaires</subject><subject>Risk factors</subject><subject>Stein-Leventhal syndrome</subject><subject>Testosterone</subject><subject>Triglycerides</subject><subject>Ultrasonic imaging</subject><subject>Vitamin deficiency</subject><subject>Womens health</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkl1rFTEQhhdRbKm98g8EvBFkaz52N8mVHA71AyotVPEyZJPJnhx3k5rsVs6_N2uLtmJykcD7zDuZyVTVS4LPGJP47d5MhJKupbR7Uh1TzHmNmWBPH9yPqtOc97gsIRpK-PPqiPGOSsrJcfV9u9NhAOQD2gSb4gDBG3Q963nJSAeLtjpZHyeYdR_HIl2l6PwIKDr02Vs7Qr0ZwKJvBQnop5936CqOB3PIc4Evb3U6oOvD6jzBi-qZ02OG0_vzpPr6_vzL9mN9cfnh03ZzUZumbeaa9c5AiyXnUkprOseddFpbLjsroRetIRIbYECAdYwU0XIu-lZI3GBGKDup3t353iz9BNZAmJMe1U3yU3mOitqrx0rwOzXEW0Vw07YN5sXh9b1Dij8WyLOafDYwjjpAXLKiouWll1Kygr76B93HJYVS328Kc9F18i816BGUDy6WxGY1VZvyFw0XBK9eZ_-hyrYweRMDrJ1_HPDmLsCkmHMC96dIgtU6H-rBfLBftJerFA</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>van der Ham, Kim</creator><creator>Koster, Maria P. 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H</au><au>Velthuis, Birgitta K</au><au>Budde, Ricardo P. J</au><au>Fauser, Bart C. J. M</au><au>Laven, Joop S. E</au><au>Louwers, Yvonne V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Change in Androgenic Status and Cardiometabolic Profile of Middle-Aged Women with Polycystic Ovary Syndrome</atitle><jtitle>Journal of clinical medicine</jtitle><date>2023-08-01</date><risdate>2023</risdate><volume>12</volume><issue>16</issue><spage>5226</spage><pages>5226-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Understanding the cardiovascular disease (CVD) risk for women with polycystic ovary syndrome (PCOS) at reproductive age is crucial. To investigate this, we compared the cardiometabolic profiles of different PCOS groups over a median interval of 15.8 years. The study focused on three groups: (1) women with PCOS who were hyperandrogenic at both initial and follow-up screening (HA-HA), (2) those who transitioned from hyperandrogenic to normoandrogenic (HA-NA), and (3) those who remained normoandrogenic (NA-NA). At initial and follow-up screenings, both HA-HA and HA-NA groups showed higher body mass indexes compared to the NA-NA group. Additionally, at follow-up, the HA-HA and HA-NA groups exhibited higher blood pressure, a higher prevalence of hypertension, elevated serum triglycerides and insulin levels, and lower levels of HDL cholesterol compared to the NA-NA group. Even after adjusting for BMI, significant differences persisted in HDL cholesterol levels and hypertension prevalence among the groups (HA-HA: 53.8%, HA-NA: 53.1%, NA-NA: 14.3%, p < 0.01). However, calcium scores and the prevalence of coronary plaques on CT scans were similar across all groups. In conclusion, women with PCOS and hyperandrogenism during their reproductive years exhibited an unfavorable cardiometabolic profile during their post-reproductive years, even if they changed to a normoandrogenic status.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>37629271</pmid><doi>10.3390/jcm12165226</doi><orcidid>https://orcid.org/0000-0003-3401-4585</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Androgens Atherosclerosis Blood pressure Calcification Cardiovascular disease Cardiovascular diseases Clinical medicine Complications and side effects Coronary vessels Diabetes Diagnosis Estrogens Gonadal disorders Health aspects High density lipoprotein Housework Hypertension Menstruation Metabolic disorders Middle aged women Morphology Ovaries Polycystic ovary syndrome Questionnaires Risk factors Stein-Leventhal syndrome Testosterone Triglycerides Ultrasonic imaging Vitamin deficiency Womens health |
| title | Change in Androgenic Status and Cardiometabolic Profile of Middle-Aged Women with Polycystic Ovary Syndrome |
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