The 3′ Non-Coding Sequence Negatively Regulates PD-L1 Expression, and Its Regulators Are Systematically Identified in Pan-Cancer

The 3′-untranslated region (3′-UTR) of PD-L1 is significantly longer than the coding sequences (CDSs). However, its role and regulators have been little studied. We deleted whole 3′-UTR region by CRISPR-Cas9. Prognostic analysis was performed using online tools. Immune infiltration analysis was perf...

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Veröffentlicht in:	Genes 2023-08, Vol.14 (8), p.1620
Hauptverfasser:	Chen, Zike, Pi, Hui, Zheng, Wen, Guo, Xiaohong, Shi, Conglin, Wang, Zhiyang, Zhang, Jie, Qu, Xuanhao, Liu, Lehan, Shen, Haoliang, Lu, Yang, Chen, Miaomiao, Zhang, Weibing, Sun, Rong, Fan, Yihui
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Antibodies B cells Cancer Cancer therapies Cells CRISPR Gene expression Immune checkpoint inhibitors Immunotherapy Lymphoma Medical research Medicine, Experimental Melanoma Metastases MicroRNAs miRNA PD-L1 protein Plasmids Protein binding RNA RNA-binding protein Software Tumor cell lines Tumor microenvironment Tumors
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