Predictors of Testicular Cancer Mortality in Brazil: A 20-Year Ecological Study
Testicular cancer is common in young men, and early detection and multimodality treatment can lead to successful outcomes. This study aims to identify sociodemographic and risk factors associated with higher testicular cancer mortality and poorer survival rates, while examining the impact of diagnos...
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| Veröffentlicht in: | Cancers 2023-08, Vol.15 (16), p.4149 |
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| creator | Franco, Ana Paula de Souza Lima Figueiredo, Eric Renato Melo, Giovana Salomão Souza, Josiel de Souza e Gonçalves, Nelson Veiga Gomes, Fabiana de Campos Neto, João Simão de Melo |
| description | Testicular cancer is common in young men, and early detection and multimodality treatment can lead to successful outcomes. This study aims to identify sociodemographic and risk factors associated with higher testicular cancer mortality and poorer survival rates, while examining the impact of diagnostic and treatment procedures on reducing mortality. The retrospective ecological study analyzed mortality data from testicular cancer in Brazil from 2001 to 2020. Sociodemographic variables such as marital status, age, birth period, year of death (cohort), race, and geographic region were assessed. Risk factors included cryptorchidism and pesticide exposure. Data were subjected to statistical analysis, which revealed an increasing trend in mortality after 2011 among persons born after 1976 in the 15–40 age group. Individuals in the South Region, whites, and singles had higher age-standardized mortality rates (ASMRs), while singles had lower survival rates. The Northeast region had a higher survival rate. Fungicides and insecticides increase ASMR in Brazil. Herbicides increase ASMR in the Northeast and Midwest regions and insecticides increase ASMR in the Northeast, Southeast, and Midwest regions. High rates of implementation of diagnostic procedures in the Midwest were not sufficient to reduce ASMR. No treatment procedure was associated with mortality at the national or regional level. |
| doi_str_mv | 10.3390/cancers15164149 |
| format | Article |
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This study aims to identify sociodemographic and risk factors associated with higher testicular cancer mortality and poorer survival rates, while examining the impact of diagnostic and treatment procedures on reducing mortality. The retrospective ecological study analyzed mortality data from testicular cancer in Brazil from 2001 to 2020. Sociodemographic variables such as marital status, age, birth period, year of death (cohort), race, and geographic region were assessed. Risk factors included cryptorchidism and pesticide exposure. Data were subjected to statistical analysis, which revealed an increasing trend in mortality after 2011 among persons born after 1976 in the 15–40 age group. Individuals in the South Region, whites, and singles had higher age-standardized mortality rates (ASMRs), while singles had lower survival rates. The Northeast region had a higher survival rate. Fungicides and insecticides increase ASMR in Brazil. Herbicides increase ASMR in the Northeast and Midwest regions and insecticides increase ASMR in the Northeast, Southeast, and Midwest regions. High rates of implementation of diagnostic procedures in the Midwest were not sufficient to reduce ASMR. No treatment procedure was associated with mortality at the national or regional level.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers15164149</identifier><identifier>PMID: 37627177</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Age ; Biomarkers ; Biopsy ; Brazil ; Cancer ; Cancer therapies ; Cell cycle ; Cell growth ; Chemotherapy ; Cryptorchidism ; Ecological studies ; Fungicides ; Genes ; Herbicides ; Insecticides ; Medical prognosis ; Metastasis ; Mortality ; Oncology, Experimental ; Patient outcomes ; Pesticides ; Risk factors ; Sperm ; Statistical analysis ; Survival ; Testes ; Testicular cancer ; Tomography ; Tumors ; Ultrasonic imaging</subject><ispartof>Cancers, 2023-08, Vol.15 (16), p.4149</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-83bf10f60989498e31a380e1a78cbb51c4092623412143333350ce670f04337d3</citedby><cites>FETCH-LOGICAL-c466t-83bf10f60989498e31a380e1a78cbb51c4092623412143333350ce670f04337d3</cites><orcidid>0000-0002-9383-8392 ; 0000-0002-4681-8532 ; 0000-0003-0364-8526</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453307/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453307/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Franco, Ana Paula de Souza</creatorcontrib><creatorcontrib>Lima Figueiredo, Eric Renato</creatorcontrib><creatorcontrib>Melo, Giovana Salomão</creatorcontrib><creatorcontrib>Souza, Josiel de Souza e</creatorcontrib><creatorcontrib>Gonçalves, Nelson Veiga</creatorcontrib><creatorcontrib>Gomes, Fabiana de Campos</creatorcontrib><creatorcontrib>Neto, João Simão de Melo</creatorcontrib><title>Predictors of Testicular Cancer Mortality in Brazil: A 20-Year Ecological Study</title><title>Cancers</title><description>Testicular cancer is common in young men, and early detection and multimodality treatment can lead to successful outcomes. This study aims to identify sociodemographic and risk factors associated with higher testicular cancer mortality and poorer survival rates, while examining the impact of diagnostic and treatment procedures on reducing mortality. The retrospective ecological study analyzed mortality data from testicular cancer in Brazil from 2001 to 2020. Sociodemographic variables such as marital status, age, birth period, year of death (cohort), race, and geographic region were assessed. Risk factors included cryptorchidism and pesticide exposure. Data were subjected to statistical analysis, which revealed an increasing trend in mortality after 2011 among persons born after 1976 in the 15–40 age group. Individuals in the South Region, whites, and singles had higher age-standardized mortality rates (ASMRs), while singles had lower survival rates. The Northeast region had a higher survival rate. Fungicides and insecticides increase ASMR in Brazil. Herbicides increase ASMR in the Northeast and Midwest regions and insecticides increase ASMR in the Northeast, Southeast, and Midwest regions. High rates of implementation of diagnostic procedures in the Midwest were not sufficient to reduce ASMR. No treatment procedure was associated with mortality at the national or regional level.</description><subject>Age</subject><subject>Biomarkers</subject><subject>Biopsy</subject><subject>Brazil</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>Chemotherapy</subject><subject>Cryptorchidism</subject><subject>Ecological studies</subject><subject>Fungicides</subject><subject>Genes</subject><subject>Herbicides</subject><subject>Insecticides</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Mortality</subject><subject>Oncology, Experimental</subject><subject>Patient outcomes</subject><subject>Pesticides</subject><subject>Risk factors</subject><subject>Sperm</subject><subject>Statistical analysis</subject><subject>Survival</subject><subject>Testes</subject><subject>Testicular cancer</subject><subject>Tomography</subject><subject>Tumors</subject><subject>Ultrasonic imaging</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkktPAyEUhYnRWFNduyVx42Ysr4EZN6Y2vhJNTdSFK0IZptLQQWHGpP56qTVqGy8LLvDdA4dcAA4xOqG0RAOtGm1CxDnmDLNyC-wRJEjGecm2_-Q9cBDjDKWgFAsudkGPCk4EFmIPjO-DqaxufYjQ1_DRxNbqzqkAR1_q8M6HVjnbLqBt4HlQH9adwiEkKHs2ibrQ3vmp1crBh7arFvtgp1YumoPvuQ-eLi8eR9fZ7fjqZjS8zTTjvM0KOqkxqjkqi5KVhaFY0QIZrEShJ5Mca4ZKwgllmGBGl5EjbbhANUpLUdE-OFvpvnaTuam0adqgnHwNdq7CQnpl5fpJY1_k1L9LjFhOKRJJ4fhbIfi3LvmWcxu1cU41xndRkiIXRU6JIAk92kBnvgtN8rekeJkX6aW_1FQ5I21T-3SxXorKYfpvJhgTKFEn_1BpVGZutW9MbdP-WsFgVaCDjzGY-sckRnLZB3KjD-gnXEqhUw</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Franco, Ana Paula de Souza</creator><creator>Lima Figueiredo, Eric Renato</creator><creator>Melo, Giovana Salomão</creator><creator>Souza, Josiel de Souza e</creator><creator>Gonçalves, Nelson Veiga</creator><creator>Gomes, Fabiana de Campos</creator><creator>Neto, João Simão de Melo</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9383-8392</orcidid><orcidid>https://orcid.org/0000-0002-4681-8532</orcidid><orcidid>https://orcid.org/0000-0003-0364-8526</orcidid></search><sort><creationdate>20230801</creationdate><title>Predictors of Testicular Cancer Mortality in Brazil: A 20-Year Ecological Study</title><author>Franco, Ana Paula de Souza ; 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This study aims to identify sociodemographic and risk factors associated with higher testicular cancer mortality and poorer survival rates, while examining the impact of diagnostic and treatment procedures on reducing mortality. The retrospective ecological study analyzed mortality data from testicular cancer in Brazil from 2001 to 2020. Sociodemographic variables such as marital status, age, birth period, year of death (cohort), race, and geographic region were assessed. Risk factors included cryptorchidism and pesticide exposure. Data were subjected to statistical analysis, which revealed an increasing trend in mortality after 2011 among persons born after 1976 in the 15–40 age group. Individuals in the South Region, whites, and singles had higher age-standardized mortality rates (ASMRs), while singles had lower survival rates. The Northeast region had a higher survival rate. Fungicides and insecticides increase ASMR in Brazil. Herbicides increase ASMR in the Northeast and Midwest regions and insecticides increase ASMR in the Northeast, Southeast, and Midwest regions. High rates of implementation of diagnostic procedures in the Midwest were not sufficient to reduce ASMR. No treatment procedure was associated with mortality at the national or regional level.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>37627177</pmid><doi>10.3390/cancers15164149</doi><orcidid>https://orcid.org/0000-0002-9383-8392</orcidid><orcidid>https://orcid.org/0000-0002-4681-8532</orcidid><orcidid>https://orcid.org/0000-0003-0364-8526</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Age Biomarkers Biopsy Brazil Cancer Cancer therapies Cell cycle Cell growth Chemotherapy Cryptorchidism Ecological studies Fungicides Genes Herbicides Insecticides Medical prognosis Metastasis Mortality Oncology, Experimental Patient outcomes Pesticides Risk factors Sperm Statistical analysis Survival Testes Testicular cancer Tomography Tumors Ultrasonic imaging |
| title | Predictors of Testicular Cancer Mortality in Brazil: A 20-Year Ecological Study |
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