Association of Nasopharynx Cancer with Human Papillomavirus Infections
This population-based study aims to examine the association between nasopharyngeal carcinoma and human papillomavirus infections. This study included 2747 individuals aged 20 years and older who were diagnosed with nasopharynx cancer as cases and 13,735 propensity-score-matching controls. Multivaria...
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| Veröffentlicht in: | Cancers 2023-08, Vol.15 (16), p.4082 |
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| creator | Hung, Shih-Han Yang, Tzong-Hann Cheng, Yen-Fu Chen, Chin-Shyan Lin, Herng-Ching |
| description | This population-based study aims to examine the association between nasopharyngeal carcinoma and human papillomavirus infections. This study included 2747 individuals aged 20 years and older who were diagnosed with nasopharynx cancer as cases and 13,735 propensity-score-matching controls. Multivariate logistic regression models were employed to quantitatively assess the association of nasopharynx cancer with human papillomavirus infections while considering age, sex, monthly income, geographic location, and urbanization level of the patient’s residence as well as diabetes, hypertension, and hyperlipidemia. Our chi-squared test indicated a significant dissimilarity in previous human papillomavirus infection rates between nasopharynx cancer patients and controls (12.7% vs. 7.2%, p < 0.001). The adjusted odds ratio (OR) for prior human papillomavirus infections was found to be significantly higher for nasopharyngeal carcinoma cases compared to controls at a value of 1.869 with confidence interval ranging from 1.640 to 2.128. Among female participants, compared to controls, the adjusted OR of prior human papillomavirus infections was 2.150 (95% CI = 1.763–2.626) in patients with nasopharynx cancer. In male participants sampled in this study, we observed a statistically significant association between prior human papillomavirus infections and nasopharynx cancer (adjusted OR = 1.689; 95% CI = 1.421–2.008). Our study indicates a noteworthy association between previous human papillomavirus infections and nasopharyngeal carcinoma. |
| doi_str_mv | 10.3390/cancers15164082 |
| format | Article |
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This study included 2747 individuals aged 20 years and older who were diagnosed with nasopharynx cancer as cases and 13,735 propensity-score-matching controls. Multivariate logistic regression models were employed to quantitatively assess the association of nasopharynx cancer with human papillomavirus infections while considering age, sex, monthly income, geographic location, and urbanization level of the patient’s residence as well as diabetes, hypertension, and hyperlipidemia. Our chi-squared test indicated a significant dissimilarity in previous human papillomavirus infection rates between nasopharynx cancer patients and controls (12.7% vs. 7.2%, p < 0.001). The adjusted odds ratio (OR) for prior human papillomavirus infections was found to be significantly higher for nasopharyngeal carcinoma cases compared to controls at a value of 1.869 with confidence interval ranging from 1.640 to 2.128. Among female participants, compared to controls, the adjusted OR of prior human papillomavirus infections was 2.150 (95% CI = 1.763–2.626) in patients with nasopharynx cancer. In male participants sampled in this study, we observed a statistically significant association between prior human papillomavirus infections and nasopharynx cancer (adjusted OR = 1.689; 95% CI = 1.421–2.008). Our study indicates a noteworthy association between previous human papillomavirus infections and nasopharyngeal carcinoma.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers15164082</identifier><identifier>PMID: 37627110</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Age ; Ambulatory care ; Cervical cancer ; Comparative analysis ; Data science ; Diabetes ; Diabetes mellitus ; Disease susceptibility ; Epstein-Barr virus ; Health care industry ; Health care policy ; Human papillomavirus ; Hyperlipidemia ; Hypertension ; Infection ; Infections ; Medical research ; Medicine, Experimental ; Nasopharyngeal cancer ; Nasopharyngeal carcinoma ; Nasopharynx ; National health insurance ; Papillomavirus infections ; Papillomaviruses ; Patients ; Population studies ; Regression analysis ; Statistical analysis ; Urbanization</subject><ispartof>Cancers, 2023-08, Vol.15 (16), p.4082</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-e17a00067767162256c0ed239da101d41d39b913aa8062b0db7cf69e684de7e13</citedby><cites>FETCH-LOGICAL-c466t-e17a00067767162256c0ed239da101d41d39b913aa8062b0db7cf69e684de7e13</cites><orcidid>0000-0003-4661-959X ; 0000-0001-9591-5489 ; 0000-0003-1276-6292</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452438/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452438/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Hung, Shih-Han</creatorcontrib><creatorcontrib>Yang, Tzong-Hann</creatorcontrib><creatorcontrib>Cheng, Yen-Fu</creatorcontrib><creatorcontrib>Chen, Chin-Shyan</creatorcontrib><creatorcontrib>Lin, Herng-Ching</creatorcontrib><title>Association of Nasopharynx Cancer with Human Papillomavirus Infections</title><title>Cancers</title><description>This population-based study aims to examine the association between nasopharyngeal carcinoma and human papillomavirus infections. This study included 2747 individuals aged 20 years and older who were diagnosed with nasopharynx cancer as cases and 13,735 propensity-score-matching controls. Multivariate logistic regression models were employed to quantitatively assess the association of nasopharynx cancer with human papillomavirus infections while considering age, sex, monthly income, geographic location, and urbanization level of the patient’s residence as well as diabetes, hypertension, and hyperlipidemia. Our chi-squared test indicated a significant dissimilarity in previous human papillomavirus infection rates between nasopharynx cancer patients and controls (12.7% vs. 7.2%, p < 0.001). The adjusted odds ratio (OR) for prior human papillomavirus infections was found to be significantly higher for nasopharyngeal carcinoma cases compared to controls at a value of 1.869 with confidence interval ranging from 1.640 to 2.128. Among female participants, compared to controls, the adjusted OR of prior human papillomavirus infections was 2.150 (95% CI = 1.763–2.626) in patients with nasopharynx cancer. In male participants sampled in this study, we observed a statistically significant association between prior human papillomavirus infections and nasopharynx cancer (adjusted OR = 1.689; 95% CI = 1.421–2.008). Our study indicates a noteworthy association between previous human papillomavirus infections and nasopharyngeal carcinoma.</description><subject>Age</subject><subject>Ambulatory care</subject><subject>Cervical cancer</subject><subject>Comparative analysis</subject><subject>Data science</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Disease susceptibility</subject><subject>Epstein-Barr virus</subject><subject>Health care industry</subject><subject>Health care policy</subject><subject>Human papillomavirus</subject><subject>Hyperlipidemia</subject><subject>Hypertension</subject><subject>Infection</subject><subject>Infections</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Nasopharyngeal cancer</subject><subject>Nasopharyngeal carcinoma</subject><subject>Nasopharynx</subject><subject>National health insurance</subject><subject>Papillomavirus infections</subject><subject>Papillomaviruses</subject><subject>Patients</subject><subject>Population studies</subject><subject>Regression analysis</subject><subject>Statistical analysis</subject><subject>Urbanization</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptUT1PwzAQtRAIqsLMGomFpdRfsZMJVRVQpAoYYLZc50KNErvYSYF_j0sRX8IefDq_9-7dHULHBJ8xVuKx0c5AiCQnguOC7qABxZKOhCj57o_4AB3F-ITTYYxIIffRAZOCSkLwAF1OYvTG6s56l_k6u9HRr5Y6vLnXbPqhn73YbpnN-la77E6vbNP4Vq9t6GN27WowG2Y8RHu1biIcfb5D9HB5cT-djea3V9fTyXxkuBDdCIjUyYeQyQYRlObCYKgoKytNMKk4qVi5KAnTusCCLnC1kKYWJYiCVyCBsCE63-qu-kULlQHXBd2oVbBt8qy8tur3j7NL9ejXimCeU86KpHD6qRD8cw-xU62NBppGO_B9VLTIZZEzKmiCnvyBPvk-uNTfBiVKKjmT36hH3YCyrvapsNmIqkkaM5ecp8EP0dk_qHQraK3xDmqb8r8I4y3BBB9jgPqrSYLVZv3qz_rZO7evoMM</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Hung, Shih-Han</creator><creator>Yang, Tzong-Hann</creator><creator>Cheng, Yen-Fu</creator><creator>Chen, Chin-Shyan</creator><creator>Lin, Herng-Ching</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4661-959X</orcidid><orcidid>https://orcid.org/0000-0001-9591-5489</orcidid><orcidid>https://orcid.org/0000-0003-1276-6292</orcidid></search><sort><creationdate>20230801</creationdate><title>Association of Nasopharynx Cancer with Human Papillomavirus Infections</title><author>Hung, Shih-Han ; Yang, Tzong-Hann ; Cheng, Yen-Fu ; Chen, Chin-Shyan ; Lin, Herng-Ching</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-e17a00067767162256c0ed239da101d41d39b913aa8062b0db7cf69e684de7e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Age</topic><topic>Ambulatory care</topic><topic>Cervical cancer</topic><topic>Comparative analysis</topic><topic>Data science</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Disease susceptibility</topic><topic>Epstein-Barr virus</topic><topic>Health care industry</topic><topic>Health care policy</topic><topic>Human papillomavirus</topic><topic>Hyperlipidemia</topic><topic>Hypertension</topic><topic>Infection</topic><topic>Infections</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Nasopharyngeal cancer</topic><topic>Nasopharyngeal carcinoma</topic><topic>Nasopharynx</topic><topic>National health insurance</topic><topic>Papillomavirus infections</topic><topic>Papillomaviruses</topic><topic>Patients</topic><topic>Population studies</topic><topic>Regression analysis</topic><topic>Statistical analysis</topic><topic>Urbanization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hung, Shih-Han</creatorcontrib><creatorcontrib>Yang, Tzong-Hann</creatorcontrib><creatorcontrib>Cheng, Yen-Fu</creatorcontrib><creatorcontrib>Chen, Chin-Shyan</creatorcontrib><creatorcontrib>Lin, Herng-Ching</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hung, Shih-Han</au><au>Yang, Tzong-Hann</au><au>Cheng, Yen-Fu</au><au>Chen, Chin-Shyan</au><au>Lin, Herng-Ching</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Nasopharynx Cancer with Human Papillomavirus Infections</atitle><jtitle>Cancers</jtitle><date>2023-08-01</date><risdate>2023</risdate><volume>15</volume><issue>16</issue><spage>4082</spage><pages>4082-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>This population-based study aims to examine the association between nasopharyngeal carcinoma and human papillomavirus infections. This study included 2747 individuals aged 20 years and older who were diagnosed with nasopharynx cancer as cases and 13,735 propensity-score-matching controls. Multivariate logistic regression models were employed to quantitatively assess the association of nasopharynx cancer with human papillomavirus infections while considering age, sex, monthly income, geographic location, and urbanization level of the patient’s residence as well as diabetes, hypertension, and hyperlipidemia. Our chi-squared test indicated a significant dissimilarity in previous human papillomavirus infection rates between nasopharynx cancer patients and controls (12.7% vs. 7.2%, p < 0.001). The adjusted odds ratio (OR) for prior human papillomavirus infections was found to be significantly higher for nasopharyngeal carcinoma cases compared to controls at a value of 1.869 with confidence interval ranging from 1.640 to 2.128. Among female participants, compared to controls, the adjusted OR of prior human papillomavirus infections was 2.150 (95% CI = 1.763–2.626) in patients with nasopharynx cancer. In male participants sampled in this study, we observed a statistically significant association between prior human papillomavirus infections and nasopharynx cancer (adjusted OR = 1.689; 95% CI = 1.421–2.008). Our study indicates a noteworthy association between previous human papillomavirus infections and nasopharyngeal carcinoma.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>37627110</pmid><doi>10.3390/cancers15164082</doi><orcidid>https://orcid.org/0000-0003-4661-959X</orcidid><orcidid>https://orcid.org/0000-0001-9591-5489</orcidid><orcidid>https://orcid.org/0000-0003-1276-6292</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Ambulatory care Cervical cancer Comparative analysis Data science Diabetes Diabetes mellitus Disease susceptibility Epstein-Barr virus Health care industry Health care policy Human papillomavirus Hyperlipidemia Hypertension Infection Infections Medical research Medicine, Experimental Nasopharyngeal cancer Nasopharyngeal carcinoma Nasopharynx National health insurance Papillomavirus infections Papillomaviruses Patients Population studies Regression analysis Statistical analysis Urbanization |
| title | Association of Nasopharynx Cancer with Human Papillomavirus Infections |
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