Characterization of an HNA aptamer suggests a non-canonical G-quadruplex motif

Abstract Nucleic acids not only form the basis of heredity, but are increasingly a source of novel nano-structures, -devices and drugs. This has spurred the development of chemically modified alternatives (xeno nucleic acids (XNAs)) comprising chemical configurations not found in nature to extend th...

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Veröffentlicht in:	Nucleic acids research 2023-08, Vol.51 (15), p.7736-7748
Hauptverfasser:	Schofield, Peter, Taylor, Alexander I, Rihon, Jérôme, Peña Martinez, Cristian D, Zinn, Sacha, Mattelaer, Charles-Alexandre, Jackson, Jennifer, Dhaliwal, Gurpreet, Schepers, Guy, Herdewijn, Piet, Lescrinier, Eveline, Christ, Daniel, Holliger, Philipp
Format:	Artikel
Sprache:	eng
Schlagworte:	Aptamers, Nucleotide - chemistry Chemical Biology and Nucleic Acid Chemistry G-Quadruplexes Ligands Molecular Dynamics Simulation Nucleic Acids - chemistry SELEX Aptamer Technique
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