Sex-specific association between prenatal androgenization (second-to-fourth digit length ratio) and frontal brain volumes in adolescents
Prenatal androgenization associates sex-dependently with behavior and mental health in adolescence and adulthood, including risk-taking, emotionality, substance use, and depression. However, still little is known on how it affects underlying neural correlates, like frontal brain control regions. Thu...
Gespeichert in:
| Veröffentlicht in: | European archives of psychiatry and clinical neuroscience 2023-09, Vol.273 (6), p.1243-1254 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1254 |
|---|---|
| container_issue | 6 |
| container_start_page | 1243 |
| container_title | European archives of psychiatry and clinical neuroscience |
| container_volume | 273 |
| creator | Lenz, Bernd Gerhardt, Sarah Boroumand-Jazi, Rafat Eichler, Anna Buchholz, Verena Nadine Fasching, Peter A. Kornhuber, Johannes Banaschewski, Tobias Flor, Herta Guldner, Stella Prignitz, Maren Nees, Frauke |
| description | Prenatal androgenization associates sex-dependently with behavior and mental health in adolescence and adulthood, including risk-taking, emotionality, substance use, and depression. However, still little is known on how it affects underlying neural correlates, like frontal brain control regions. Thus, we tested whether prenatal androgen load is sex-dependently related to frontal cortex volumes in a sex-balanced adolescent sample. In a cross-sectional magnetic resonance imaging study, we examined 61 adolescents (28 males, 33 females; aged 14 or 16 years) and analyzed associations of frontal brain region volumes with the second-to-fourth digit length ratio (2D:4D), an established marker for prenatal androgenization, using voxel-based morphometry in a region-of-interest approach. Lower 2D:4D (indicative of higher prenatal androgen load) correlated significantly with smaller volumes of the right anterior cingulate cortex (r-ACC;
β
= 0.45) in male adolescents and with larger volumes of the left inferior frontal gyrus orbital part (l-IFGorb;
β
= – 0.38) in female adolescents. The regression slopes of 2D:4D on the r-ACC also differed significantly between males and females. The study provides novel evidence that prenatal androgenization may influence the development of the frontal brain in a sex- and frontal brain region-specific manner. These effects might contribute to the well-known sex differences in risk-taking, emotionality, substance use, and depression. Future research is needed to elucidate the role of prenatal androgenization within the biopsychosocial model. |
| doi_str_mv | 10.1007/s00406-022-01515-4 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10449726</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A762138493</galeid><sourcerecordid>A762138493</sourcerecordid><originalsourceid>FETCH-LOGICAL-c519t-1fb31ea7c32c21bcb81f2263ac912b1391768f2e13c1e3be22dc5f6744e552273</originalsourceid><addsrcrecordid>eNp9kstu1TAQhi0EoocDL8AqEpt24eKxndsKVVW5SJVYAGvLccapq8Q-2EkLPAGPjUMqqiKEvPDt-2c845-Ql8BOgbH6dWJMsooyzimDEkoqH5EdSCFoI1t4THaslYyCEPKIPEvpmrGMcfaUHIlKZoKJHfn5Cb_RdEDjrDOFTikYp2cXfNHhfIvoi0NEr2c9Ftr3MQzo3Y8NOE5ogu_pHKgNS5yvit4Nbi5G9EPexJU6WVWFjcGvEbqonS9uwrhMmIq81H0YMRn0c3pOnlg9JnxxN-_Jl7cXn8_f08uP7z6cn11SU0I7U7CdANS1Edxw6EzXgOW8Etq0wDsQLdRVYzmCMICiQ857U9qqlhLLkvNa7MmbLe5h6Sbs19xRj-oQ3aTjdxW0Uw9vvLtSQ7hRwHLP6pxqT47vIsTwdcE0q8nlGsZRewxLUryWomRlK9uMvvoLvc6d8rk-xZuyqmRdNtU9NegRlfM25MRmDarO6oqDyN8pMnX6DyqPHieXPwKty-cPBHwTmBhSimj_FAlMrQZSm4FUNpD6bSAls0hsopRhP2C8f_F_VL8AEqHIbw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2856647586</pqid></control><display><type>article</type><title>Sex-specific association between prenatal androgenization (second-to-fourth digit length ratio) and frontal brain volumes in adolescents</title><source>SpringerLink Journals - AutoHoldings</source><creator>Lenz, Bernd ; Gerhardt, Sarah ; Boroumand-Jazi, Rafat ; Eichler, Anna ; Buchholz, Verena Nadine ; Fasching, Peter A. ; Kornhuber, Johannes ; Banaschewski, Tobias ; Flor, Herta ; Guldner, Stella ; Prignitz, Maren ; Nees, Frauke</creator><creatorcontrib>Lenz, Bernd ; Gerhardt, Sarah ; Boroumand-Jazi, Rafat ; Eichler, Anna ; Buchholz, Verena Nadine ; Fasching, Peter A. ; Kornhuber, Johannes ; Banaschewski, Tobias ; Flor, Herta ; Guldner, Stella ; Prignitz, Maren ; Nees, Frauke ; IMAC-Mind Consortium</creatorcontrib><description>Prenatal androgenization associates sex-dependently with behavior and mental health in adolescence and adulthood, including risk-taking, emotionality, substance use, and depression. However, still little is known on how it affects underlying neural correlates, like frontal brain control regions. Thus, we tested whether prenatal androgen load is sex-dependently related to frontal cortex volumes in a sex-balanced adolescent sample. In a cross-sectional magnetic resonance imaging study, we examined 61 adolescents (28 males, 33 females; aged 14 or 16 years) and analyzed associations of frontal brain region volumes with the second-to-fourth digit length ratio (2D:4D), an established marker for prenatal androgenization, using voxel-based morphometry in a region-of-interest approach. Lower 2D:4D (indicative of higher prenatal androgen load) correlated significantly with smaller volumes of the right anterior cingulate cortex (r-ACC;
β
= 0.45) in male adolescents and with larger volumes of the left inferior frontal gyrus orbital part (l-IFGorb;
β
= – 0.38) in female adolescents. The regression slopes of 2D:4D on the r-ACC also differed significantly between males and females. The study provides novel evidence that prenatal androgenization may influence the development of the frontal brain in a sex- and frontal brain region-specific manner. These effects might contribute to the well-known sex differences in risk-taking, emotionality, substance use, and depression. Future research is needed to elucidate the role of prenatal androgenization within the biopsychosocial model.</description><identifier>ISSN: 0940-1334</identifier><identifier>EISSN: 1433-8491</identifier><identifier>DOI: 10.1007/s00406-022-01515-4</identifier><identifier>PMID: 36449103</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescence ; Adolescents ; Androgens ; Brain ; Cortex (cingulate) ; Cortex (frontal) ; Drug use ; Emotions ; Frontal gyrus ; Magnetic resonance imaging ; Males ; Medicine ; Medicine & Public Health ; Mental depression ; Mental health ; Morphometry ; Neuroimaging ; Neurosciences ; Original Paper ; Pregnant women ; Psychiatry ; Sex differences ; Substance abuse ; Substance use ; Teenage girls ; Teenagers</subject><ispartof>European archives of psychiatry and clinical neuroscience, 2023-09, Vol.273 (6), p.1243-1254</ispartof><rights>The Author(s) 2022</rights><rights>COPYRIGHT 2023 Springer</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-1fb31ea7c32c21bcb81f2263ac912b1391768f2e13c1e3be22dc5f6744e552273</citedby><cites>FETCH-LOGICAL-c519t-1fb31ea7c32c21bcb81f2263ac912b1391768f2e13c1e3be22dc5f6744e552273</cites><orcidid>0000-0001-6086-0924 ; 0000-0002-8096-3987 ; 0000-0003-4595-1144 ; 0000-0003-4885-8471 ; 0000-0001-5584-0961 ; 0000-0001-5896-2294 ; 0000-0001-9570-7874 ; 0000-0001-7085-881X ; 0000-0002-7796-8234 ; 0000-0003-4809-5398 ; 0000-0001-7060-7711 ; 0000-0001-6607-8490</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00406-022-01515-4$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00406-022-01515-4$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,778,782,883,27907,27908,41471,42540,51302</link.rule.ids></links><search><creatorcontrib>Lenz, Bernd</creatorcontrib><creatorcontrib>Gerhardt, Sarah</creatorcontrib><creatorcontrib>Boroumand-Jazi, Rafat</creatorcontrib><creatorcontrib>Eichler, Anna</creatorcontrib><creatorcontrib>Buchholz, Verena Nadine</creatorcontrib><creatorcontrib>Fasching, Peter A.</creatorcontrib><creatorcontrib>Kornhuber, Johannes</creatorcontrib><creatorcontrib>Banaschewski, Tobias</creatorcontrib><creatorcontrib>Flor, Herta</creatorcontrib><creatorcontrib>Guldner, Stella</creatorcontrib><creatorcontrib>Prignitz, Maren</creatorcontrib><creatorcontrib>Nees, Frauke</creatorcontrib><creatorcontrib>IMAC-Mind Consortium</creatorcontrib><title>Sex-specific association between prenatal androgenization (second-to-fourth digit length ratio) and frontal brain volumes in adolescents</title><title>European archives of psychiatry and clinical neuroscience</title><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><description>Prenatal androgenization associates sex-dependently with behavior and mental health in adolescence and adulthood, including risk-taking, emotionality, substance use, and depression. However, still little is known on how it affects underlying neural correlates, like frontal brain control regions. Thus, we tested whether prenatal androgen load is sex-dependently related to frontal cortex volumes in a sex-balanced adolescent sample. In a cross-sectional magnetic resonance imaging study, we examined 61 adolescents (28 males, 33 females; aged 14 or 16 years) and analyzed associations of frontal brain region volumes with the second-to-fourth digit length ratio (2D:4D), an established marker for prenatal androgenization, using voxel-based morphometry in a region-of-interest approach. Lower 2D:4D (indicative of higher prenatal androgen load) correlated significantly with smaller volumes of the right anterior cingulate cortex (r-ACC;
β
= 0.45) in male adolescents and with larger volumes of the left inferior frontal gyrus orbital part (l-IFGorb;
β
= – 0.38) in female adolescents. The regression slopes of 2D:4D on the r-ACC also differed significantly between males and females. The study provides novel evidence that prenatal androgenization may influence the development of the frontal brain in a sex- and frontal brain region-specific manner. These effects might contribute to the well-known sex differences in risk-taking, emotionality, substance use, and depression. Future research is needed to elucidate the role of prenatal androgenization within the biopsychosocial model.</description><subject>Adolescence</subject><subject>Adolescents</subject><subject>Androgens</subject><subject>Brain</subject><subject>Cortex (cingulate)</subject><subject>Cortex (frontal)</subject><subject>Drug use</subject><subject>Emotions</subject><subject>Frontal gyrus</subject><subject>Magnetic resonance imaging</subject><subject>Males</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental depression</subject><subject>Mental health</subject><subject>Morphometry</subject><subject>Neuroimaging</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Pregnant women</subject><subject>Psychiatry</subject><subject>Sex differences</subject><subject>Substance abuse</subject><subject>Substance use</subject><subject>Teenage girls</subject><subject>Teenagers</subject><issn>0940-1334</issn><issn>1433-8491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kstu1TAQhi0EoocDL8AqEpt24eKxndsKVVW5SJVYAGvLccapq8Q-2EkLPAGPjUMqqiKEvPDt-2c845-Ql8BOgbH6dWJMsooyzimDEkoqH5EdSCFoI1t4THaslYyCEPKIPEvpmrGMcfaUHIlKZoKJHfn5Cb_RdEDjrDOFTikYp2cXfNHhfIvoi0NEr2c9Ftr3MQzo3Y8NOE5ogu_pHKgNS5yvit4Nbi5G9EPexJU6WVWFjcGvEbqonS9uwrhMmIq81H0YMRn0c3pOnlg9JnxxN-_Jl7cXn8_f08uP7z6cn11SU0I7U7CdANS1Edxw6EzXgOW8Etq0wDsQLdRVYzmCMICiQ857U9qqlhLLkvNa7MmbLe5h6Sbs19xRj-oQ3aTjdxW0Uw9vvLtSQ7hRwHLP6pxqT47vIsTwdcE0q8nlGsZRewxLUryWomRlK9uMvvoLvc6d8rk-xZuyqmRdNtU9NegRlfM25MRmDarO6oqDyN8pMnX6DyqPHieXPwKty-cPBHwTmBhSimj_FAlMrQZSm4FUNpD6bSAls0hsopRhP2C8f_F_VL8AEqHIbw</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Lenz, Bernd</creator><creator>Gerhardt, Sarah</creator><creator>Boroumand-Jazi, Rafat</creator><creator>Eichler, Anna</creator><creator>Buchholz, Verena Nadine</creator><creator>Fasching, Peter A.</creator><creator>Kornhuber, Johannes</creator><creator>Banaschewski, Tobias</creator><creator>Flor, Herta</creator><creator>Guldner, Stella</creator><creator>Prignitz, Maren</creator><creator>Nees, Frauke</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6086-0924</orcidid><orcidid>https://orcid.org/0000-0002-8096-3987</orcidid><orcidid>https://orcid.org/0000-0003-4595-1144</orcidid><orcidid>https://orcid.org/0000-0003-4885-8471</orcidid><orcidid>https://orcid.org/0000-0001-5584-0961</orcidid><orcidid>https://orcid.org/0000-0001-5896-2294</orcidid><orcidid>https://orcid.org/0000-0001-9570-7874</orcidid><orcidid>https://orcid.org/0000-0001-7085-881X</orcidid><orcidid>https://orcid.org/0000-0002-7796-8234</orcidid><orcidid>https://orcid.org/0000-0003-4809-5398</orcidid><orcidid>https://orcid.org/0000-0001-7060-7711</orcidid><orcidid>https://orcid.org/0000-0001-6607-8490</orcidid></search><sort><creationdate>20230901</creationdate><title>Sex-specific association between prenatal androgenization (second-to-fourth digit length ratio) and frontal brain volumes in adolescents</title><author>Lenz, Bernd ; Gerhardt, Sarah ; Boroumand-Jazi, Rafat ; Eichler, Anna ; Buchholz, Verena Nadine ; Fasching, Peter A. ; Kornhuber, Johannes ; Banaschewski, Tobias ; Flor, Herta ; Guldner, Stella ; Prignitz, Maren ; Nees, Frauke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-1fb31ea7c32c21bcb81f2263ac912b1391768f2e13c1e3be22dc5f6744e552273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adolescence</topic><topic>Adolescents</topic><topic>Androgens</topic><topic>Brain</topic><topic>Cortex (cingulate)</topic><topic>Cortex (frontal)</topic><topic>Drug use</topic><topic>Emotions</topic><topic>Frontal gyrus</topic><topic>Magnetic resonance imaging</topic><topic>Males</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental depression</topic><topic>Mental health</topic><topic>Morphometry</topic><topic>Neuroimaging</topic><topic>Neurosciences</topic><topic>Original Paper</topic><topic>Pregnant women</topic><topic>Psychiatry</topic><topic>Sex differences</topic><topic>Substance abuse</topic><topic>Substance use</topic><topic>Teenage girls</topic><topic>Teenagers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lenz, Bernd</creatorcontrib><creatorcontrib>Gerhardt, Sarah</creatorcontrib><creatorcontrib>Boroumand-Jazi, Rafat</creatorcontrib><creatorcontrib>Eichler, Anna</creatorcontrib><creatorcontrib>Buchholz, Verena Nadine</creatorcontrib><creatorcontrib>Fasching, Peter A.</creatorcontrib><creatorcontrib>Kornhuber, Johannes</creatorcontrib><creatorcontrib>Banaschewski, Tobias</creatorcontrib><creatorcontrib>Flor, Herta</creatorcontrib><creatorcontrib>Guldner, Stella</creatorcontrib><creatorcontrib>Prignitz, Maren</creatorcontrib><creatorcontrib>Nees, Frauke</creatorcontrib><creatorcontrib>IMAC-Mind Consortium</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European archives of psychiatry and clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lenz, Bernd</au><au>Gerhardt, Sarah</au><au>Boroumand-Jazi, Rafat</au><au>Eichler, Anna</au><au>Buchholz, Verena Nadine</au><au>Fasching, Peter A.</au><au>Kornhuber, Johannes</au><au>Banaschewski, Tobias</au><au>Flor, Herta</au><au>Guldner, Stella</au><au>Prignitz, Maren</au><au>Nees, Frauke</au><aucorp>IMAC-Mind Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex-specific association between prenatal androgenization (second-to-fourth digit length ratio) and frontal brain volumes in adolescents</atitle><jtitle>European archives of psychiatry and clinical neuroscience</jtitle><stitle>Eur Arch Psychiatry Clin Neurosci</stitle><date>2023-09-01</date><risdate>2023</risdate><volume>273</volume><issue>6</issue><spage>1243</spage><epage>1254</epage><pages>1243-1254</pages><issn>0940-1334</issn><eissn>1433-8491</eissn><abstract>Prenatal androgenization associates sex-dependently with behavior and mental health in adolescence and adulthood, including risk-taking, emotionality, substance use, and depression. However, still little is known on how it affects underlying neural correlates, like frontal brain control regions. Thus, we tested whether prenatal androgen load is sex-dependently related to frontal cortex volumes in a sex-balanced adolescent sample. In a cross-sectional magnetic resonance imaging study, we examined 61 adolescents (28 males, 33 females; aged 14 or 16 years) and analyzed associations of frontal brain region volumes with the second-to-fourth digit length ratio (2D:4D), an established marker for prenatal androgenization, using voxel-based morphometry in a region-of-interest approach. Lower 2D:4D (indicative of higher prenatal androgen load) correlated significantly with smaller volumes of the right anterior cingulate cortex (r-ACC;
β
= 0.45) in male adolescents and with larger volumes of the left inferior frontal gyrus orbital part (l-IFGorb;
β
= – 0.38) in female adolescents. The regression slopes of 2D:4D on the r-ACC also differed significantly between males and females. The study provides novel evidence that prenatal androgenization may influence the development of the frontal brain in a sex- and frontal brain region-specific manner. These effects might contribute to the well-known sex differences in risk-taking, emotionality, substance use, and depression. Future research is needed to elucidate the role of prenatal androgenization within the biopsychosocial model.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36449103</pmid><doi>10.1007/s00406-022-01515-4</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-6086-0924</orcidid><orcidid>https://orcid.org/0000-0002-8096-3987</orcidid><orcidid>https://orcid.org/0000-0003-4595-1144</orcidid><orcidid>https://orcid.org/0000-0003-4885-8471</orcidid><orcidid>https://orcid.org/0000-0001-5584-0961</orcidid><orcidid>https://orcid.org/0000-0001-5896-2294</orcidid><orcidid>https://orcid.org/0000-0001-9570-7874</orcidid><orcidid>https://orcid.org/0000-0001-7085-881X</orcidid><orcidid>https://orcid.org/0000-0002-7796-8234</orcidid><orcidid>https://orcid.org/0000-0003-4809-5398</orcidid><orcidid>https://orcid.org/0000-0001-7060-7711</orcidid><orcidid>https://orcid.org/0000-0001-6607-8490</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0940-1334 |
| ispartof | European archives of psychiatry and clinical neuroscience, 2023-09, Vol.273 (6), p.1243-1254 |
| issn | 0940-1334 1433-8491 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10449726 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Adolescence Adolescents Androgens Brain Cortex (cingulate) Cortex (frontal) Drug use Emotions Frontal gyrus Magnetic resonance imaging Males Medicine Medicine & Public Health Mental depression Mental health Morphometry Neuroimaging Neurosciences Original Paper Pregnant women Psychiatry Sex differences Substance abuse Substance use Teenage girls Teenagers |
| title | Sex-specific association between prenatal androgenization (second-to-fourth digit length ratio) and frontal brain volumes in adolescents |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T23%3A01%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sex-specific%20association%20between%20prenatal%20androgenization%20(second-to-fourth%20digit%20length%20ratio)%20and%20frontal%20brain%20volumes%20in%20adolescents&rft.jtitle=European%20archives%20of%20psychiatry%20and%20clinical%20neuroscience&rft.au=Lenz,%20Bernd&rft.aucorp=IMAC-Mind%20Consortium&rft.date=2023-09-01&rft.volume=273&rft.issue=6&rft.spage=1243&rft.epage=1254&rft.pages=1243-1254&rft.issn=0940-1334&rft.eissn=1433-8491&rft_id=info:doi/10.1007/s00406-022-01515-4&rft_dat=%3Cgale_pubme%3EA762138493%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2856647586&rft_id=info:pmid/36449103&rft_galeid=A762138493&rfr_iscdi=true |