Temporal Evolution of Perihematomal Blood-Brain Barrier Compromise and Edema Growth After Intracerebral Hemorrhage
Purpose The aim of this study was to investigate the temporal evolution of perihematomal blood-brain barrier (BBB) compromise and edema growth and to determine the role of BBB compromise in edema growth. Methods Spontaneous intracerebral hemorrhage patients who underwent computed tomography perfusio...
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| Veröffentlicht in: | Clinical neuroradiology (Munich) 2023-09, Vol.33 (3), p.813-824 |
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| creator | Yang, Dan Wang, Xin Zhang, Xue Zhu, Huachen Sun, Shengjun Mane, Ravikiran Zhao, Xingquan Zhou, Jian |
| description | Purpose
The aim of this study was to investigate the temporal evolution of perihematomal blood-brain barrier (BBB) compromise and edema growth and to determine the role of BBB compromise in edema growth.
Methods
Spontaneous intracerebral hemorrhage patients who underwent computed tomography perfusion (CTP) were divided into five groups according to the time interval from symptom onset to CTP examination. Permeability-surface area product (PS) maps were generated using CTP source images. Ipsilateral and contralateral mean PS values were computed in the perihematomal and contralateral mirror regions. The relative PS (rPS) value was calculated as a ratio of ipsilateral to contralateral PS value. Hematoma and perihematomal edema volume were determined on non-contrast CT images.
Results
In the total of 101 intracerebral hemorrhage patients, the ipsilateral mean PS value was significantly higher than that in contralateral region (z = −8.284,
p
|
| doi_str_mv | 10.1007/s00062-023-01285-z |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10449681</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A762137478</galeid><sourcerecordid>A762137478</sourcerecordid><originalsourceid>FETCH-LOGICAL-c542t-19c1c2d054c3a125d18789bc2275aeb7550dfdcde080c6f4549dc40e32e116a43</originalsourceid><addsrcrecordid>eNp9kktr3DAUhU1paUKaP9BFMXTTjVM9LXlVZobJAwLtIl0LjXQ9o2BL02tPQvPrK2fSSVNK0cLC97sHncMpiveUnFFC1OeBEFKzijBeEcq0rB5eFcdU101FhVCvD3feHBWnw3CbccJ1I6V6WxxxRbWsa31c4A3024S2K5d3qduNIcUyteU3wLCB3o6pz6N5l5Kv5mhDLOcWMQCWi9RvMfVhgNJGXy59pssLTPfjppy1Yyau4ojWAcJqkr-EPiFu7BreFW9a2w1w-vQ9Kb6fL28Wl9X114urxey6clKwsaKNo455IoXjljLpqVa6WTnGlLSwUlIS33rngWji6lZI0XgnCHAGlNZW8JPiy153u1v14B1M7-nMFkNv8adJNpiXkxg2Zp3uDCVCNLWmWeHTkwKmHzsYRpP9Oug6GyHtBsM0FZIJXk_ox7_Q27TDmP1lKkfNOWfqmVrbDkyIbZoimkTNTNWMciWUztTZP6h8csbBpQhtyP9fLLD9gsM0DAjtwSQlZmqL2bfF5LaYx7aYh7z04c94Diu_u5EBvgeGPIprwGdL_5H9Bbt6yso</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2856633327</pqid></control><display><type>article</type><title>Temporal Evolution of Perihematomal Blood-Brain Barrier Compromise and Edema Growth After Intracerebral Hemorrhage</title><source>SpringerLink Journals</source><creator>Yang, Dan ; Wang, Xin ; Zhang, Xue ; Zhu, Huachen ; Sun, Shengjun ; Mane, Ravikiran ; Zhao, Xingquan ; Zhou, Jian</creator><creatorcontrib>Yang, Dan ; Wang, Xin ; Zhang, Xue ; Zhu, Huachen ; Sun, Shengjun ; Mane, Ravikiran ; Zhao, Xingquan ; Zhou, Jian</creatorcontrib><description>Purpose
The aim of this study was to investigate the temporal evolution of perihematomal blood-brain barrier (BBB) compromise and edema growth and to determine the role of BBB compromise in edema growth.
Methods
Spontaneous intracerebral hemorrhage patients who underwent computed tomography perfusion (CTP) were divided into five groups according to the time interval from symptom onset to CTP examination. Permeability-surface area product (PS) maps were generated using CTP source images. Ipsilateral and contralateral mean PS values were computed in the perihematomal and contralateral mirror regions. The relative PS (rPS) value was calculated as a ratio of ipsilateral to contralateral PS value. Hematoma and perihematomal edema volume were determined on non-contrast CT images.
Results
In the total of 101 intracerebral hemorrhage patients, the ipsilateral mean PS value was significantly higher than that in contralateral region (z = −8.284,
p
< 0.001). The perihematomal BBB permeability showed a course of dynamic changes including an increase in the hyperacute and acute phases, a decrease in the early subacute phase and a second increase in the late subacute phase and chronic phase. Perihematomal edema increased gradually until the late subacute phase and then slightly increased. There was a relationship between rPS value and edema volume (β = 0.254,
p
= 0.006).
Conclusion
The perihematomal BBB permeability is dynamic changes, and edema growth is gradually increased in patients following intracerebral hemorrhage. BBB compromise plays an essential role in edema growth. The quantitative assessment of BBB compromise may provide valuable information in therapeutic interventions of intracerebral hemorrhage patients.</description><identifier>ISSN: 1869-1439</identifier><identifier>EISSN: 1869-1447</identifier><identifier>DOI: 10.1007/s00062-023-01285-z</identifier><identifier>PMID: 37185668</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Blood-brain barrier ; Brain ; CT imaging ; Dropsy ; Edema ; Growth ; Hemorrhage ; Intracerebral hemorrhage ; Medicine ; Medicine & Public Health ; Neurology ; Neuroradiology ; Neurosurgery ; Original ; Original Article ; Permeability</subject><ispartof>Clinical neuroradiology (Munich), 2023-09, Vol.33 (3), p.813-824</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>COPYRIGHT 2023 Springer</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-19c1c2d054c3a125d18789bc2275aeb7550dfdcde080c6f4549dc40e32e116a43</citedby><cites>FETCH-LOGICAL-c542t-19c1c2d054c3a125d18789bc2275aeb7550dfdcde080c6f4549dc40e32e116a43</cites><orcidid>0000-0002-0822-8320</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00062-023-01285-z$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00062-023-01285-z$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37185668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Dan</creatorcontrib><creatorcontrib>Wang, Xin</creatorcontrib><creatorcontrib>Zhang, Xue</creatorcontrib><creatorcontrib>Zhu, Huachen</creatorcontrib><creatorcontrib>Sun, Shengjun</creatorcontrib><creatorcontrib>Mane, Ravikiran</creatorcontrib><creatorcontrib>Zhao, Xingquan</creatorcontrib><creatorcontrib>Zhou, Jian</creatorcontrib><title>Temporal Evolution of Perihematomal Blood-Brain Barrier Compromise and Edema Growth After Intracerebral Hemorrhage</title><title>Clinical neuroradiology (Munich)</title><addtitle>Clin Neuroradiol</addtitle><addtitle>Clin Neuroradiol</addtitle><description>Purpose
The aim of this study was to investigate the temporal evolution of perihematomal blood-brain barrier (BBB) compromise and edema growth and to determine the role of BBB compromise in edema growth.
Methods
Spontaneous intracerebral hemorrhage patients who underwent computed tomography perfusion (CTP) were divided into five groups according to the time interval from symptom onset to CTP examination. Permeability-surface area product (PS) maps were generated using CTP source images. Ipsilateral and contralateral mean PS values were computed in the perihematomal and contralateral mirror regions. The relative PS (rPS) value was calculated as a ratio of ipsilateral to contralateral PS value. Hematoma and perihematomal edema volume were determined on non-contrast CT images.
Results
In the total of 101 intracerebral hemorrhage patients, the ipsilateral mean PS value was significantly higher than that in contralateral region (z = −8.284,
p
< 0.001). The perihematomal BBB permeability showed a course of dynamic changes including an increase in the hyperacute and acute phases, a decrease in the early subacute phase and a second increase in the late subacute phase and chronic phase. Perihematomal edema increased gradually until the late subacute phase and then slightly increased. There was a relationship between rPS value and edema volume (β = 0.254,
p
= 0.006).
Conclusion
The perihematomal BBB permeability is dynamic changes, and edema growth is gradually increased in patients following intracerebral hemorrhage. BBB compromise plays an essential role in edema growth. The quantitative assessment of BBB compromise may provide valuable information in therapeutic interventions of intracerebral hemorrhage patients.</description><subject>Blood-brain barrier</subject><subject>Brain</subject><subject>CT imaging</subject><subject>Dropsy</subject><subject>Edema</subject><subject>Growth</subject><subject>Hemorrhage</subject><subject>Intracerebral hemorrhage</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosurgery</subject><subject>Original</subject><subject>Original Article</subject><subject>Permeability</subject><issn>1869-1439</issn><issn>1869-1447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kktr3DAUhU1paUKaP9BFMXTTjVM9LXlVZobJAwLtIl0LjXQ9o2BL02tPQvPrK2fSSVNK0cLC97sHncMpiveUnFFC1OeBEFKzijBeEcq0rB5eFcdU101FhVCvD3feHBWnw3CbccJ1I6V6WxxxRbWsa31c4A3024S2K5d3qduNIcUyteU3wLCB3o6pz6N5l5Kv5mhDLOcWMQCWi9RvMfVhgNJGXy59pssLTPfjppy1Yyau4ojWAcJqkr-EPiFu7BreFW9a2w1w-vQ9Kb6fL28Wl9X114urxey6clKwsaKNo455IoXjljLpqVa6WTnGlLSwUlIS33rngWji6lZI0XgnCHAGlNZW8JPiy153u1v14B1M7-nMFkNv8adJNpiXkxg2Zp3uDCVCNLWmWeHTkwKmHzsYRpP9Oug6GyHtBsM0FZIJXk_ox7_Q27TDmP1lKkfNOWfqmVrbDkyIbZoimkTNTNWMciWUztTZP6h8csbBpQhtyP9fLLD9gsM0DAjtwSQlZmqL2bfF5LaYx7aYh7z04c94Diu_u5EBvgeGPIprwGdL_5H9Bbt6yso</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Yang, Dan</creator><creator>Wang, Xin</creator><creator>Zhang, Xue</creator><creator>Zhu, Huachen</creator><creator>Sun, Shengjun</creator><creator>Mane, Ravikiran</creator><creator>Zhao, Xingquan</creator><creator>Zhou, Jian</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0822-8320</orcidid></search><sort><creationdate>20230901</creationdate><title>Temporal Evolution of Perihematomal Blood-Brain Barrier Compromise and Edema Growth After Intracerebral Hemorrhage</title><author>Yang, Dan ; Wang, Xin ; Zhang, Xue ; Zhu, Huachen ; Sun, Shengjun ; Mane, Ravikiran ; Zhao, Xingquan ; Zhou, Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-19c1c2d054c3a125d18789bc2275aeb7550dfdcde080c6f4549dc40e32e116a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Blood-brain barrier</topic><topic>Brain</topic><topic>CT imaging</topic><topic>Dropsy</topic><topic>Edema</topic><topic>Growth</topic><topic>Hemorrhage</topic><topic>Intracerebral hemorrhage</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosurgery</topic><topic>Original</topic><topic>Original Article</topic><topic>Permeability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Dan</creatorcontrib><creatorcontrib>Wang, Xin</creatorcontrib><creatorcontrib>Zhang, Xue</creatorcontrib><creatorcontrib>Zhu, Huachen</creatorcontrib><creatorcontrib>Sun, Shengjun</creatorcontrib><creatorcontrib>Mane, Ravikiran</creatorcontrib><creatorcontrib>Zhao, Xingquan</creatorcontrib><creatorcontrib>Zhou, Jian</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical neuroradiology (Munich)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Dan</au><au>Wang, Xin</au><au>Zhang, Xue</au><au>Zhu, Huachen</au><au>Sun, Shengjun</au><au>Mane, Ravikiran</au><au>Zhao, Xingquan</au><au>Zhou, Jian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temporal Evolution of Perihematomal Blood-Brain Barrier Compromise and Edema Growth After Intracerebral Hemorrhage</atitle><jtitle>Clinical neuroradiology (Munich)</jtitle><stitle>Clin Neuroradiol</stitle><addtitle>Clin Neuroradiol</addtitle><date>2023-09-01</date><risdate>2023</risdate><volume>33</volume><issue>3</issue><spage>813</spage><epage>824</epage><pages>813-824</pages><issn>1869-1439</issn><eissn>1869-1447</eissn><abstract>Purpose
The aim of this study was to investigate the temporal evolution of perihematomal blood-brain barrier (BBB) compromise and edema growth and to determine the role of BBB compromise in edema growth.
Methods
Spontaneous intracerebral hemorrhage patients who underwent computed tomography perfusion (CTP) were divided into five groups according to the time interval from symptom onset to CTP examination. Permeability-surface area product (PS) maps were generated using CTP source images. Ipsilateral and contralateral mean PS values were computed in the perihematomal and contralateral mirror regions. The relative PS (rPS) value was calculated as a ratio of ipsilateral to contralateral PS value. Hematoma and perihematomal edema volume were determined on non-contrast CT images.
Results
In the total of 101 intracerebral hemorrhage patients, the ipsilateral mean PS value was significantly higher than that in contralateral region (z = −8.284,
p
< 0.001). The perihematomal BBB permeability showed a course of dynamic changes including an increase in the hyperacute and acute phases, a decrease in the early subacute phase and a second increase in the late subacute phase and chronic phase. Perihematomal edema increased gradually until the late subacute phase and then slightly increased. There was a relationship between rPS value and edema volume (β = 0.254,
p
= 0.006).
Conclusion
The perihematomal BBB permeability is dynamic changes, and edema growth is gradually increased in patients following intracerebral hemorrhage. BBB compromise plays an essential role in edema growth. The quantitative assessment of BBB compromise may provide valuable information in therapeutic interventions of intracerebral hemorrhage patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37185668</pmid><doi>10.1007/s00062-023-01285-z</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-0822-8320</orcidid><oa>free_for_read</oa></addata></record> |
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| source | SpringerLink Journals |
| subjects | Blood-brain barrier Brain CT imaging Dropsy Edema Growth Hemorrhage Intracerebral hemorrhage Medicine Medicine & Public Health Neurology Neuroradiology Neurosurgery Original Original Article Permeability |
| title | Temporal Evolution of Perihematomal Blood-Brain Barrier Compromise and Edema Growth After Intracerebral Hemorrhage |
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