COVID-19 vaccine triggered autoimmune hepatitis: case report
Autoimmune hepatitis (AIH) is a non-contagious, chronic, inflammatory autoimmune disease in which one’s own immune system attacks healthy, normal hepatic cells. The exact cause of AIH is unknown; however, the combination of genetic, environmental (eg, drugs and natural infection) and immunological f...
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| Veröffentlicht in: | European journal of hospital pharmacy. Science and practice 2023-09, Vol.30 (5), p.e1.6-e4 |
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| creator | Mathew, Merrin John, Sheba Baby Sebastian, Juny Ravi, Mandyam Dhati |
| description | Autoimmune hepatitis (AIH) is a non-contagious, chronic, inflammatory autoimmune disease in which one’s own immune system attacks healthy, normal hepatic cells. The exact cause of AIH is unknown; however, the combination of genetic, environmental (eg, drugs and natural infection) and immunological factors may lead to AIH. AIH may also be potentiated with the use of vaccines: this case reports one such event following immunisation, along with 1 year of follow-up. A female patient in her late 20s presented to the hospital with yellowish discolouration of eyes, urine and stools. Her medical history revealed that she had been vaccinated with the first dose of a COVID-19 vaccine 10 days earlier. She had a history of asymptomatic COVID-19 infection 3 months ago and a history of chronic analgesic consumption for migraine. She was diagnosed as having AIH through extensive clinical and laboratory workup. This case may be an immediate enhancement of a hidden autoimmune disorder triggered by the vaccination. This adverse event following immunisation has an adequate temporal relationship with her COVID-19 vaccine. The causality can be categorised as ‘indeterminate’ and may be considered as a potential signal following COVID-19 vaccination. |
| doi_str_mv | 10.1136/ejhpharm-2022-003485 |
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The exact cause of AIH is unknown; however, the combination of genetic, environmental (eg, drugs and natural infection) and immunological factors may lead to AIH. AIH may also be potentiated with the use of vaccines: this case reports one such event following immunisation, along with 1 year of follow-up. A female patient in her late 20s presented to the hospital with yellowish discolouration of eyes, urine and stools. Her medical history revealed that she had been vaccinated with the first dose of a COVID-19 vaccine 10 days earlier. She had a history of asymptomatic COVID-19 infection 3 months ago and a history of chronic analgesic consumption for migraine. She was diagnosed as having AIH through extensive clinical and laboratory workup. This case may be an immediate enhancement of a hidden autoimmune disorder triggered by the vaccination. This adverse event following immunisation has an adequate temporal relationship with her COVID-19 vaccine. The causality can be categorised as ‘indeterminate’ and may be considered as a potential signal following COVID-19 vaccination.</description><identifier>ISSN: 2047-9956</identifier><identifier>EISSN: 2047-9964</identifier><identifier>DOI: 10.1136/ejhpharm-2022-003485</identifier><identifier>PMID: 36207131</identifier><language>eng</language><publisher>London: British Medical Journal Publishing Group</publisher><subject>ALLERGY AND IMMUNOLOGY ; Analgesics ; Asymptomatic ; Autoimmune diseases ; Biopsy ; Caffeine ; Case Report ; Case reports ; Coronaviruses ; COVID-19 ; COVID-19 vaccines ; Drug dosages ; Drug therapy ; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS ; Genetic engineering ; Headaches ; Hepatitis ; Immunization ; Infections ; Liver ; Pharmacy ; PHARMACY SERVICE, HOSPITAL ; Safety ; Severe acute respiratory syndrome coronavirus 2 ; Steroids ; Toxicity ; Vectors (Biology) ; Viral infections</subject><ispartof>European journal of hospital pharmacy. Science and practice, 2023-09, Vol.30 (5), p.e1.6-e4</ispartof><rights>European Association of Hospital Pharmacists 2022. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>This article is made freely available for personal use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained. https://bmj.com/coronavirus/usage</rights><rights>European Association of Hospital Pharmacists 2023. No commercial re-use. See rights and permissions. 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Science and practice</title><addtitle>Eur J Hosp Pharm</addtitle><description>Autoimmune hepatitis (AIH) is a non-contagious, chronic, inflammatory autoimmune disease in which one’s own immune system attacks healthy, normal hepatic cells. The exact cause of AIH is unknown; however, the combination of genetic, environmental (eg, drugs and natural infection) and immunological factors may lead to AIH. AIH may also be potentiated with the use of vaccines: this case reports one such event following immunisation, along with 1 year of follow-up. A female patient in her late 20s presented to the hospital with yellowish discolouration of eyes, urine and stools. Her medical history revealed that she had been vaccinated with the first dose of a COVID-19 vaccine 10 days earlier. She had a history of asymptomatic COVID-19 infection 3 months ago and a history of chronic analgesic consumption for migraine. She was diagnosed as having AIH through extensive clinical and laboratory workup. This case may be an immediate enhancement of a hidden autoimmune disorder triggered by the vaccination. This adverse event following immunisation has an adequate temporal relationship with her COVID-19 vaccine. 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John, Sheba Baby ; Sebastian, Juny ; Ravi, Mandyam Dhati</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b483t-fcb59fa706a181a1864fee05d8023babf6acf0ce1cc4305facc134b7956bfd933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>ALLERGY AND IMMUNOLOGY</topic><topic>Analgesics</topic><topic>Asymptomatic</topic><topic>Autoimmune diseases</topic><topic>Biopsy</topic><topic>Caffeine</topic><topic>Case Report</topic><topic>Case reports</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 vaccines</topic><topic>Drug dosages</topic><topic>Drug therapy</topic><topic>DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS</topic><topic>Genetic engineering</topic><topic>Headaches</topic><topic>Hepatitis</topic><topic>Immunization</topic><topic>Infections</topic><topic>Liver</topic><topic>Pharmacy</topic><topic>PHARMACY SERVICE, HOSPITAL</topic><topic>Safety</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Steroids</topic><topic>Toxicity</topic><topic>Vectors (Biology)</topic><topic>Viral infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mathew, Merrin</creatorcontrib><creatorcontrib>John, Sheba Baby</creatorcontrib><creatorcontrib>Sebastian, Juny</creatorcontrib><creatorcontrib>Ravi, Mandyam Dhati</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of hospital pharmacy. Science and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mathew, Merrin</au><au>John, Sheba Baby</au><au>Sebastian, Juny</au><au>Ravi, Mandyam Dhati</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>COVID-19 vaccine triggered autoimmune hepatitis: case report</atitle><jtitle>European journal of hospital pharmacy. Science and practice</jtitle><stitle>Eur J Hosp Pharm</stitle><date>2023-09-01</date><risdate>2023</risdate><volume>30</volume><issue>5</issue><spage>e1.6</spage><epage>e4</epage><pages>e1.6-e4</pages><issn>2047-9956</issn><eissn>2047-9964</eissn><abstract>Autoimmune hepatitis (AIH) is a non-contagious, chronic, inflammatory autoimmune disease in which one’s own immune system attacks healthy, normal hepatic cells. 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| subjects | ALLERGY AND IMMUNOLOGY Analgesics Asymptomatic Autoimmune diseases Biopsy Caffeine Case Report Case reports Coronaviruses COVID-19 COVID-19 vaccines Drug dosages Drug therapy DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS Genetic engineering Headaches Hepatitis Immunization Infections Liver Pharmacy PHARMACY SERVICE, HOSPITAL Safety Severe acute respiratory syndrome coronavirus 2 Steroids Toxicity Vectors (Biology) Viral infections |
| title | COVID-19 vaccine triggered autoimmune hepatitis: case report |
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