Genetic events associated with venetoclax resistance in CLL identified by whole-exome sequencing of patient samples

•Clonal evolution on venetoclax selects for 8p deletion, which leads to increased venetoclax resistance in vitro.•Elevated Erk signaling and constitutively high BCR signaling are associated with venetoclax progression. [Display omitted] Although BCL2 mutations are reported as later occurring events...

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Veröffentlicht in:	Blood 2023-08, Vol.142 (5), p.421-433
Hauptverfasser:	Khalsa, Jasneet Kaur, Cha, Justin, Utro, Filippo, Naeem, Aishath, Murali, Ishwarya, Kuang, Yanan, Vasquez, Kevin, Li, Liang, Tyekucheva, Svitlana, Fernandes, Stacey M., Veronese, Lauren, Guieze, Romain, Sasi, Binu Kandathilparambil, Wang, Zixu, Machado, John-Hanson, Bai, Harrison, Alasfour, Maryam, Rhrissorrakrai, Kahn, Levovitz, Chaya, Danysh, Brian P., Slowik, Kara, Jacobs, Raquel A., Davids, Matthew S., Paweletz, Cloud P., Leshchiner, Ignaty, Parida, Laxmi, Getz, Gad, Brown, Jennifer R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Bridged Bicyclo Compounds, Heterocyclic - pharmacology Drug Resistance, Neoplasm - genetics Exome Sequencing Humans Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - pathology Lymphoid Neoplasia Myeloid Cell Leukemia Sequence 1 Protein - genetics Proto-Oncogene Proteins c-bcl-2
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