Transient naive reprogramming corrects hiPS cells functionally and epigenetically

Cells undergo a major epigenome reconfiguration when reprogrammed to human induced pluripotent stem cells (hiPS cells). However, the epigenomes of hiPS cells and human embryonic stem (hES) cells differ significantly, which affects hiPS cell function 1 – 8 . These differences include epigenetic memor...

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Veröffentlicht in:	Nature (London) 2023-08, Vol.620 (7975), p.863-872
Hauptverfasser:	Buckberry, Sam, Liu, Xiaodong, Poppe, Daniel, Tan, Jia Ping, Sun, Guizhi, Chen, Joseph, Nguyen, Trung Viet, de Mendoza, Alex, Pflueger, Jahnvi, Frazer, Thomas, Vargas-Landín, Dulce B., Paynter, Jacob M., Smits, Nathan, Liu, Ning, Ouyang, John F., Rossello, Fernando J., Chy, Hun S., Rackham, Owen J. L., Laslett, Andrew L., Breen, James, Faulkner, Geoffrey J., Nefzger, Christian M., Polo, Jose M., Lister, Ryan
Format:	Artikel
Sprache:	eng
Schlagworte:	45/100 45/15 45/22 45/23 45/91 631/136/2442 631/208/177 631/532/2435 Aberration Cell differentiation Cellular Reprogramming Chromatin Chromatin - genetics Chromatin - metabolism Demethylation Deoxyribonucleic acid Differentiation DNA DNA Demethylation DNA fingerprinting DNA Methylation DNA Transposable Elements Epigenesis, Genetic Epigenetics Fibroblasts Gene expression Genomes Genomic imprinting Human Embryonic Stem Cells - cytology Human Embryonic Stem Cells - metabolism Humanities and Social Sciences Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Lamin Type B multidisciplinary Pluripotency Reconfiguration Science Science (multidisciplinary) Somatic cells Stem cells Therapeutic applications Transcription factors
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