Chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review

Chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review

Abstract Chromophobe renal cell carcinoma (CRCC) is a subtype of renal cell carcinoma (RCC) with a favorable prognosis. Sarcomatoid differentiation in RCC is assumed to be the outcome of the parent tumor’s dedifferentiation and associated with poorer prognosis. Sarcomatoid differentiation can be det...

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Veröffentlicht in:Journal of surgical case reports 2023-08, Vol.2023 (8)
Hauptverfasser: Abuorouq, Saleh, Sahawneh, Firas, Halalsheh, Omar, Haddad, Husam K, Mekail, Raed, Alzoubi, Hiba, Alrjoub, Mo’ath, Serhan, Hashem A
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Case Series
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container_issue 8
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container_title Journal of surgical case reports
container_volume 2023
creator Abuorouq, Saleh
Sahawneh, Firas
Halalsheh, Omar
Haddad, Husam K
Mekail, Raed
Alzoubi, Hiba
Alrjoub, Mo’ath
Serhan, Hashem A
description Abstract Chromophobe renal cell carcinoma (CRCC) is a subtype of renal cell carcinoma (RCC) with a favorable prognosis. Sarcomatoid differentiation in RCC is assumed to be the outcome of the parent tumor’s dedifferentiation and associated with poorer prognosis. Sarcomatoid differentiation can be detected in CRCC as well as other subtypes, but the occurrence of divergent osteosarcoma-like components in sarcomatoid CRCC is extremely unusual. Only six cases have been previously reported in the literature, we reviewed them and presented the seventh case in a 71-year-old male who had a left kidney heterogeneous mass. The resected tumor showed a sarcoma-like spindle cell area with an adjacent osteosarcoma area producing lacy bone material and bony trabeculae in a hard area mixed with a typical CRCC. In conclusion, sarcomatoid CRCC with osteosarcomatous differentiation is a very rare tumor and should be kept in mind especially when dealing with small or frozen sections biopsies.
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title Chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review
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