Higher hippocampal diffusivity values in welders are associated with greater R2 in the red nucleus and lower psychomotor performance
Chronic excessive welding exposure may be related to higher metal accumulation and structural differences in different subcortical structures. We examined how welding affected brain structures and their associations with metal exposure and neurobehavioral consequences. Study includes 42 welders and...
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| Veröffentlicht in: | Neurotoxicology (Park Forest South) 2023-05, Vol.96, p.53-68 |
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| creator | Lee, Eun-Young Kim, Juhee Prado-Rico, Janina Manzieri Du, Guangwei Lewis, Mechelle M. Kong, Lan Kim, Byoung-Gwon Hong, Young-Seoub Yanosky, Jeff D. Mailman, Richard B. Huang, Xuemei |
| description | Chronic excessive welding exposure may be related to higher metal accumulation and structural differences in different subcortical structures. We examined how welding affected brain structures and their associations with metal exposure and neurobehavioral consequences.
Study includes 42 welders and 31 controls without a welding history. Welding-related structural differences were assessed by volume and diffusion tensor imaging (DTI) metrics in basal ganglia, red nucleus (RN), and hippocampus. Metal exposure was estimated by both exposure questionnaires and whole blood metal levels. Brain metal accumulations were estimated by R1 (for Mn) and R2* (for Fe). Neurobehavioral status was assessed by standard neuropsychological tests.
Compared to controls, welders displayed higher hippocampal mean (MD), axial (AD), and radial diffusivity (RD) (p’s 0.117). Welders had higher blood metal levels (p’s |
| doi_str_mv | 10.1016/j.neuro.2023.03.005 |
| format | Article |
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Study includes 42 welders and 31 controls without a welding history. Welding-related structural differences were assessed by volume and diffusion tensor imaging (DTI) metrics in basal ganglia, red nucleus (RN), and hippocampus. Metal exposure was estimated by both exposure questionnaires and whole blood metal levels. Brain metal accumulations were estimated by R1 (for Mn) and R2* (for Fe). Neurobehavioral status was assessed by standard neuropsychological tests.
Compared to controls, welders displayed higher hippocampal mean (MD), axial (AD), and radial diffusivity (RD) (p’s < 0.036), but similar DTI or volume in other ROIs (p’s > 0.117). Welders had higher blood metal levels (p’s < 0.004), higher caudate and RN R2* (p’s < 0.014), and lower performance on processing/psychomotor speed, executive function, and visuospatial processing tasks (p’s < 0.046). Higher caudate and RN R2* were associated with higher blood Fe and Pb (p’s < 0.043), respectively. RN R2* was a significant predictor of all hippocampal diffusivity metrics (p’s < 0.006). Higher hippocampal MD and RD values were associated with lower Trail Making Test-A scores (p’s < 0.025). A mediation analysis of both groups revealed blood Pb indirectly affected hippocampal diffusivity via RN R2* (p’s < 0.041).
Welding-related higher hippocampal diffusivity metrics may be associated with higher RN R2* and lower psychomotor speed performance. Future studies are warranted to test the role of Pb exposure in these findings.
•Welders had higher R2* values in the caudate and red nucleus (RN) that were associated with higher whole blood Fe and Pb.•Welders displayed higher hippocampal mean (MD), axial (AD), and radial diffusivity (RD) without volume differences.•Welders showed lower performance on processing/psychomotor speed, executive function, and visuospatial processing domains.•Higher hippocampal MD and RD values were associated with greater RN R2* values and lower Trail Making Test-A scores.•Blood Pb indirectly affected all hippocampal diffusivity metrics via RN R2*R2* when considering both groups together.]]></description><identifier>ISSN: 0161-813X</identifier><identifier>EISSN: 1872-9711</identifier><identifier>DOI: 10.1016/j.neuro.2023.03.005</identifier><identifier>PMID: 36966945</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Diffusion tensor imaging ; Diffusion Tensor Imaging - methods ; Hippocampus ; Hippocampus - diagnostic imaging ; Humans ; Lead - analysis ; Metal Workers ; Occupational Exposure - adverse effects ; Occupational Exposure - analysis ; Psychomotor Performance ; Psychomotor speed ; Red nucleus ; Red Nucleus - chemistry ; Welding</subject><ispartof>Neurotoxicology (Park Forest South), 2023-05, Vol.96, p.53-68</ispartof><rights>2023 Elsevier B.V.</rights><rights>Copyright © 2023 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c330t-bd437fc37e824dc81a5be12a78ec8314bddda3d2d5f823aca53efdbfcad2f15d3</citedby><cites>FETCH-LOGICAL-c330t-bd437fc37e824dc81a5be12a78ec8314bddda3d2d5f823aca53efdbfcad2f15d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0161813X23000463$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36966945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Eun-Young</creatorcontrib><creatorcontrib>Kim, Juhee</creatorcontrib><creatorcontrib>Prado-Rico, Janina Manzieri</creatorcontrib><creatorcontrib>Du, Guangwei</creatorcontrib><creatorcontrib>Lewis, Mechelle M.</creatorcontrib><creatorcontrib>Kong, Lan</creatorcontrib><creatorcontrib>Kim, Byoung-Gwon</creatorcontrib><creatorcontrib>Hong, Young-Seoub</creatorcontrib><creatorcontrib>Yanosky, Jeff D.</creatorcontrib><creatorcontrib>Mailman, Richard B.</creatorcontrib><creatorcontrib>Huang, Xuemei</creatorcontrib><title>Higher hippocampal diffusivity values in welders are associated with greater R2 in the red nucleus and lower psychomotor performance</title><title>Neurotoxicology (Park Forest South)</title><addtitle>Neurotoxicology</addtitle><description><![CDATA[Chronic excessive welding exposure may be related to higher metal accumulation and structural differences in different subcortical structures. We examined how welding affected brain structures and their associations with metal exposure and neurobehavioral consequences.
Study includes 42 welders and 31 controls without a welding history. Welding-related structural differences were assessed by volume and diffusion tensor imaging (DTI) metrics in basal ganglia, red nucleus (RN), and hippocampus. Metal exposure was estimated by both exposure questionnaires and whole blood metal levels. Brain metal accumulations were estimated by R1 (for Mn) and R2* (for Fe). Neurobehavioral status was assessed by standard neuropsychological tests.
Compared to controls, welders displayed higher hippocampal mean (MD), axial (AD), and radial diffusivity (RD) (p’s < 0.036), but similar DTI or volume in other ROIs (p’s > 0.117). Welders had higher blood metal levels (p’s < 0.004), higher caudate and RN R2* (p’s < 0.014), and lower performance on processing/psychomotor speed, executive function, and visuospatial processing tasks (p’s < 0.046). Higher caudate and RN R2* were associated with higher blood Fe and Pb (p’s < 0.043), respectively. RN R2* was a significant predictor of all hippocampal diffusivity metrics (p’s < 0.006). Higher hippocampal MD and RD values were associated with lower Trail Making Test-A scores (p’s < 0.025). A mediation analysis of both groups revealed blood Pb indirectly affected hippocampal diffusivity via RN R2* (p’s < 0.041).
Welding-related higher hippocampal diffusivity metrics may be associated with higher RN R2* and lower psychomotor speed performance. Future studies are warranted to test the role of Pb exposure in these findings.
•Welders had higher R2* values in the caudate and red nucleus (RN) that were associated with higher whole blood Fe and Pb.•Welders displayed higher hippocampal mean (MD), axial (AD), and radial diffusivity (RD) without volume differences.•Welders showed lower performance on processing/psychomotor speed, executive function, and visuospatial processing domains.•Higher hippocampal MD and RD values were associated with greater RN R2* values and lower Trail Making Test-A scores.•Blood Pb indirectly affected all hippocampal diffusivity metrics via RN R2*R2* when considering both groups together.]]></description><subject>Diffusion tensor imaging</subject><subject>Diffusion Tensor Imaging - methods</subject><subject>Hippocampus</subject><subject>Hippocampus - diagnostic imaging</subject><subject>Humans</subject><subject>Lead - analysis</subject><subject>Metal Workers</subject><subject>Occupational Exposure - adverse effects</subject><subject>Occupational Exposure - analysis</subject><subject>Psychomotor Performance</subject><subject>Psychomotor speed</subject><subject>Red nucleus</subject><subject>Red Nucleus - chemistry</subject><subject>Welding</subject><issn>0161-813X</issn><issn>1872-9711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UVtrFDEYDaLYbfUXCJJHX2bNZTKXBxEp1QoFQVrwLWSSLztZZiZjktll3_3hzXZrsS_CB0k4ly-cg9A7StaU0Orjdj3BEvyaEcbXJA8RL9CKNjUr2prSl2iVWbRoKP91hs5j3BJCRV21r9EZr9qqakuxQn-u3aaHgHs3z16rcVYDNs7aJbqdSwe8U8MCEbsJ72EwECJWAbCK0WunEhi8d6nHmwD5EfBPdmSmHnDI0LToAZasmAwe_D7jczzo3o8--XyHYH0Y1aThDXpl1RDh7eN5ge6-Xt1eXhc3P759v_xyU2jOSSo6U_Laal5Dw0qjG6pEB5SpugHdcFp2xhjFDTPCNowrrQQHazqrlWGWCsMv0OeT77x0IxgNUwpqkHNwowoH6ZWTz5HJ9XLjd5KSshSMltnhw6ND8L9zMEmOLmoYBjWBX6JkdUtr0hBRZyo_UXXwMQawT3sokccC5VY-FCiPBUqSh4isev_vF580fxvLhE8nAuSgdg6CjNpBDtG4ADpJ491_F9wDYGmzpQ</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Lee, Eun-Young</creator><creator>Kim, Juhee</creator><creator>Prado-Rico, Janina Manzieri</creator><creator>Du, Guangwei</creator><creator>Lewis, Mechelle M.</creator><creator>Kong, Lan</creator><creator>Kim, Byoung-Gwon</creator><creator>Hong, Young-Seoub</creator><creator>Yanosky, Jeff D.</creator><creator>Mailman, Richard B.</creator><creator>Huang, Xuemei</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230501</creationdate><title>Higher hippocampal diffusivity values in welders are associated with greater R2 in the red nucleus and lower psychomotor performance</title><author>Lee, Eun-Young ; Kim, Juhee ; Prado-Rico, Janina Manzieri ; Du, Guangwei ; Lewis, Mechelle M. ; Kong, Lan ; Kim, Byoung-Gwon ; Hong, Young-Seoub ; Yanosky, Jeff D. ; Mailman, Richard B. ; Huang, Xuemei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c330t-bd437fc37e824dc81a5be12a78ec8314bddda3d2d5f823aca53efdbfcad2f15d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Diffusion tensor imaging</topic><topic>Diffusion Tensor Imaging - methods</topic><topic>Hippocampus</topic><topic>Hippocampus - diagnostic imaging</topic><topic>Humans</topic><topic>Lead - analysis</topic><topic>Metal Workers</topic><topic>Occupational Exposure - adverse effects</topic><topic>Occupational Exposure - analysis</topic><topic>Psychomotor Performance</topic><topic>Psychomotor speed</topic><topic>Red nucleus</topic><topic>Red Nucleus - chemistry</topic><topic>Welding</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Eun-Young</creatorcontrib><creatorcontrib>Kim, Juhee</creatorcontrib><creatorcontrib>Prado-Rico, Janina Manzieri</creatorcontrib><creatorcontrib>Du, Guangwei</creatorcontrib><creatorcontrib>Lewis, Mechelle M.</creatorcontrib><creatorcontrib>Kong, Lan</creatorcontrib><creatorcontrib>Kim, Byoung-Gwon</creatorcontrib><creatorcontrib>Hong, Young-Seoub</creatorcontrib><creatorcontrib>Yanosky, Jeff D.</creatorcontrib><creatorcontrib>Mailman, Richard B.</creatorcontrib><creatorcontrib>Huang, Xuemei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurotoxicology (Park Forest South)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Eun-Young</au><au>Kim, Juhee</au><au>Prado-Rico, Janina Manzieri</au><au>Du, Guangwei</au><au>Lewis, Mechelle M.</au><au>Kong, Lan</au><au>Kim, Byoung-Gwon</au><au>Hong, Young-Seoub</au><au>Yanosky, Jeff D.</au><au>Mailman, Richard B.</au><au>Huang, Xuemei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Higher hippocampal diffusivity values in welders are associated with greater R2 in the red nucleus and lower psychomotor performance</atitle><jtitle>Neurotoxicology (Park Forest South)</jtitle><addtitle>Neurotoxicology</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>96</volume><spage>53</spage><epage>68</epage><pages>53-68</pages><issn>0161-813X</issn><eissn>1872-9711</eissn><abstract><![CDATA[Chronic excessive welding exposure may be related to higher metal accumulation and structural differences in different subcortical structures. We examined how welding affected brain structures and their associations with metal exposure and neurobehavioral consequences.
Study includes 42 welders and 31 controls without a welding history. Welding-related structural differences were assessed by volume and diffusion tensor imaging (DTI) metrics in basal ganglia, red nucleus (RN), and hippocampus. Metal exposure was estimated by both exposure questionnaires and whole blood metal levels. Brain metal accumulations were estimated by R1 (for Mn) and R2* (for Fe). Neurobehavioral status was assessed by standard neuropsychological tests.
Compared to controls, welders displayed higher hippocampal mean (MD), axial (AD), and radial diffusivity (RD) (p’s < 0.036), but similar DTI or volume in other ROIs (p’s > 0.117). Welders had higher blood metal levels (p’s < 0.004), higher caudate and RN R2* (p’s < 0.014), and lower performance on processing/psychomotor speed, executive function, and visuospatial processing tasks (p’s < 0.046). Higher caudate and RN R2* were associated with higher blood Fe and Pb (p’s < 0.043), respectively. RN R2* was a significant predictor of all hippocampal diffusivity metrics (p’s < 0.006). Higher hippocampal MD and RD values were associated with lower Trail Making Test-A scores (p’s < 0.025). A mediation analysis of both groups revealed blood Pb indirectly affected hippocampal diffusivity via RN R2* (p’s < 0.041).
Welding-related higher hippocampal diffusivity metrics may be associated with higher RN R2* and lower psychomotor speed performance. Future studies are warranted to test the role of Pb exposure in these findings.
•Welders had higher R2* values in the caudate and red nucleus (RN) that were associated with higher whole blood Fe and Pb.•Welders displayed higher hippocampal mean (MD), axial (AD), and radial diffusivity (RD) without volume differences.•Welders showed lower performance on processing/psychomotor speed, executive function, and visuospatial processing domains.•Higher hippocampal MD and RD values were associated with greater RN R2* values and lower Trail Making Test-A scores.•Blood Pb indirectly affected all hippocampal diffusivity metrics via RN R2*R2* when considering both groups together.]]></abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>36966945</pmid><doi>10.1016/j.neuro.2023.03.005</doi><tpages>16</tpages></addata></record> |
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| ispartof | Neurotoxicology (Park Forest South), 2023-05, Vol.96, p.53-68 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Diffusion tensor imaging Diffusion Tensor Imaging - methods Hippocampus Hippocampus - diagnostic imaging Humans Lead - analysis Metal Workers Occupational Exposure - adverse effects Occupational Exposure - analysis Psychomotor Performance Psychomotor speed Red nucleus Red Nucleus - chemistry Welding |
| title | Higher hippocampal diffusivity values in welders are associated with greater R2 in the red nucleus and lower psychomotor performance |
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