Postoperative infectious complications following laparoscopic versus open hepatectomy for hepatocellular carcinoma: a multicenter propensity score analysis of 3876 patients

OBJECTIVESHepatocellular carcinoma (HCC) is a common indication for hepatectomy that is often complicated by postoperative complication. The authors sought to investigate the relationship between the open with laparoscopic approach of hepatectomy and incidences of postoperative infectious complicati...

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Veröffentlicht in:International journal of surgery (London, England) England), 2023-08, Vol.109 (8), p.2267-2275
Hauptverfasser: Pu, Jia-Le, Xu, Xiao, Chen, Lan-Lan, Li, Chao, Jia, Hang-Dong, Fan, Zhong-Qi, Li, Ju-Dong, Guan, Ming-Cheng, Liang, Ying-Jian, Zhou, Ya-Hao, Wang, Xian-Ming, Gu, Wei-Min, Wang, Hong, Li, Jie, Chen, Zhi-Yu, Chen, Ting-Hao, Zhang, Yao-Ming, Chen, Zi-Xiang, Yao, Lan-Qing, Diao, Yong-Kang, Wang, Ming-Da, Shen, Feng, Pawlik, Timothy M., Lau, Wan Yee, Chen, Zhong, Yang, Tian, Lv, Guo-Yue
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container_title International journal of surgery (London, England)
container_volume 109
creator Pu, Jia-Le
Xu, Xiao
Chen, Lan-Lan
Li, Chao
Jia, Hang-Dong
Fan, Zhong-Qi
Li, Ju-Dong
Guan, Ming-Cheng
Liang, Ying-Jian
Zhou, Ya-Hao
Wang, Xian-Ming
Gu, Wei-Min
Wang, Hong
Li, Jie
Chen, Zhi-Yu
Chen, Ting-Hao
Zhang, Yao-Ming
Chen, Zi-Xiang
Yao, Lan-Qing
Diao, Yong-Kang
Wang, Ming-Da
Shen, Feng
Pawlik, Timothy M.
Lau, Wan Yee
Chen, Zhong
Yang, Tian
Lv, Guo-Yue
description OBJECTIVESHepatocellular carcinoma (HCC) is a common indication for hepatectomy that is often complicated by postoperative complication. The authors sought to investigate the relationship between the open with laparoscopic approach of hepatectomy and incidences of postoperative infectious complications. PATIENTS AND METHODSUsing a multicenter database, HCC patients who underwent laparoscopic hepatectomy (LH) or open hepatectomy (OH) were reviewed and analyzed. Propensity score matching (PSM), inverse probability of treatment weight (IPTW), and multivariate logistic regression analyses were utilized to assess the association of the operative approach with postoperative infectious complications, including incisional surgical site infection (SSI), organ/space SSI, and remote infection (RI). RESULTSAmong 3876 patients, 845 (21.8%) and 3031 (78.2%) patients underwent LH and OH, respectively. The overall incidence of infection was 6.9 versus 14.6% among patients who underwent LH versus OH, respectively ( P
doi_str_mv 10.1097/JS9.0000000000000446
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The authors sought to investigate the relationship between the open with laparoscopic approach of hepatectomy and incidences of postoperative infectious complications. PATIENTS AND METHODSUsing a multicenter database, HCC patients who underwent laparoscopic hepatectomy (LH) or open hepatectomy (OH) were reviewed and analyzed. Propensity score matching (PSM), inverse probability of treatment weight (IPTW), and multivariate logistic regression analyses were utilized to assess the association of the operative approach with postoperative infectious complications, including incisional surgical site infection (SSI), organ/space SSI, and remote infection (RI). RESULTSAmong 3876 patients, 845 (21.8%) and 3031 (78.2%) patients underwent LH and OH, respectively. The overall incidence of infection was 6.9 versus 14.6% among patients who underwent LH versus OH, respectively ( P &lt;0.001). Of note, the incidences of incisional SSI (1.8 vs. 6.3%, P &lt;0.001), organ/space SSI (1.8 vs. 4.6%, P &lt;0.001), and RI (3.8 vs. 9.8%, P &lt;0.001) were all significantly lower among patients who underwent LH versus OH. After PSM (6.9, 1.8, 1.8, and 3.8% vs. 18.5, 8.4, 5.2, and 12.8%, respectively) and IPTW (9.5, 2.3, 2.1, and 5.5% vs. 14.3, 6.3, 4.5, and 9.8%, respectively), LH remained associated with statistically lower incidences of all types of infectious complications. After adjustment for other confounding factors on multivariate analyses, LH remained independently associated with lower incidences of overall infection, incisional SSI, organ/space SSI, and RI in the overall, PSM, and IPTW cohorts, respectively. CONCLUSIONCompared with open approach, laparoscopic approach was independently associated with lower incidences of postoperative infectious complications following hepatectomy for HCC.</description><identifier>ISSN: 1743-9159</identifier><identifier>ISSN: 1743-9191</identifier><identifier>EISSN: 1743-9159</identifier><identifier>DOI: 10.1097/JS9.0000000000000446</identifier><identifier>PMID: 37161522</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams &amp; Wilkins</publisher><subject>Original Research</subject><ispartof>International journal of surgery (London, England), 2023-08, Vol.109 (8), p.2267-2275</ispartof><rights>Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-817f4e00e6ddd977eee6f9aef3ddeb53a14309824e38b1e46048bbfea937030f3</citedby><cites>FETCH-LOGICAL-c386t-817f4e00e6ddd977eee6f9aef3ddeb53a14309824e38b1e46048bbfea937030f3</cites><orcidid>0000-0002-9707-3390 ; 0000-0002-1075-5592 ; 0000-0002-3425-4688 ; 0000-0001-6984-3290 ; 0000-0001-7638-2605</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,865,886,27928,27929</link.rule.ids></links><search><creatorcontrib>Pu, Jia-Le</creatorcontrib><creatorcontrib>Xu, Xiao</creatorcontrib><creatorcontrib>Chen, Lan-Lan</creatorcontrib><creatorcontrib>Li, Chao</creatorcontrib><creatorcontrib>Jia, Hang-Dong</creatorcontrib><creatorcontrib>Fan, Zhong-Qi</creatorcontrib><creatorcontrib>Li, Ju-Dong</creatorcontrib><creatorcontrib>Guan, Ming-Cheng</creatorcontrib><creatorcontrib>Liang, Ying-Jian</creatorcontrib><creatorcontrib>Zhou, Ya-Hao</creatorcontrib><creatorcontrib>Wang, Xian-Ming</creatorcontrib><creatorcontrib>Gu, Wei-Min</creatorcontrib><creatorcontrib>Wang, Hong</creatorcontrib><creatorcontrib>Li, Jie</creatorcontrib><creatorcontrib>Chen, Zhi-Yu</creatorcontrib><creatorcontrib>Chen, Ting-Hao</creatorcontrib><creatorcontrib>Zhang, Yao-Ming</creatorcontrib><creatorcontrib>Chen, Zi-Xiang</creatorcontrib><creatorcontrib>Yao, Lan-Qing</creatorcontrib><creatorcontrib>Diao, Yong-Kang</creatorcontrib><creatorcontrib>Wang, Ming-Da</creatorcontrib><creatorcontrib>Shen, Feng</creatorcontrib><creatorcontrib>Pawlik, Timothy M.</creatorcontrib><creatorcontrib>Lau, Wan Yee</creatorcontrib><creatorcontrib>Chen, Zhong</creatorcontrib><creatorcontrib>Yang, Tian</creatorcontrib><creatorcontrib>Lv, Guo-Yue</creatorcontrib><title>Postoperative infectious complications following laparoscopic versus open hepatectomy for hepatocellular carcinoma: a multicenter propensity score analysis of 3876 patients</title><title>International journal of surgery (London, England)</title><description>OBJECTIVESHepatocellular carcinoma (HCC) is a common indication for hepatectomy that is often complicated by postoperative complication. The authors sought to investigate the relationship between the open with laparoscopic approach of hepatectomy and incidences of postoperative infectious complications. PATIENTS AND METHODSUsing a multicenter database, HCC patients who underwent laparoscopic hepatectomy (LH) or open hepatectomy (OH) were reviewed and analyzed. Propensity score matching (PSM), inverse probability of treatment weight (IPTW), and multivariate logistic regression analyses were utilized to assess the association of the operative approach with postoperative infectious complications, including incisional surgical site infection (SSI), organ/space SSI, and remote infection (RI). RESULTSAmong 3876 patients, 845 (21.8%) and 3031 (78.2%) patients underwent LH and OH, respectively. The overall incidence of infection was 6.9 versus 14.6% among patients who underwent LH versus OH, respectively ( P &lt;0.001). Of note, the incidences of incisional SSI (1.8 vs. 6.3%, P &lt;0.001), organ/space SSI (1.8 vs. 4.6%, P &lt;0.001), and RI (3.8 vs. 9.8%, P &lt;0.001) were all significantly lower among patients who underwent LH versus OH. After PSM (6.9, 1.8, 1.8, and 3.8% vs. 18.5, 8.4, 5.2, and 12.8%, respectively) and IPTW (9.5, 2.3, 2.1, and 5.5% vs. 14.3, 6.3, 4.5, and 9.8%, respectively), LH remained associated with statistically lower incidences of all types of infectious complications. After adjustment for other confounding factors on multivariate analyses, LH remained independently associated with lower incidences of overall infection, incisional SSI, organ/space SSI, and RI in the overall, PSM, and IPTW cohorts, respectively. CONCLUSIONCompared with open approach, laparoscopic approach was independently associated with lower incidences of postoperative infectious complications following hepatectomy for HCC.</description><subject>Original Research</subject><issn>1743-9159</issn><issn>1743-9191</issn><issn>1743-9159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkc2OFSEQhYnROOPoG7hg6eaO0NDd4MaYib-ZRBN1TarpYgZDQwv0NfedfEi5uRMzygYKTn1UziHkOWeXnOnx5aev-pLdX1IOD8g5H6XYad7rh_fOZ-RJKT-ahCmuHpMzMfKB9113Tn5_SaWmFTNUv0fqo0NbfdoKtWlZg7ftPsVCXQoh_fLxhgZYIadi0-ot3WMuTdsAkd7iCrV1p-XQ5PlUJ4shbAEytZCtj2mBVxTosoXqLcaKma752F58PdBGzUghQjgU37COCjUOtHF805an5JGDUPDZ3X5Bvr97--3qw-768_uPV2-ud1aooe4UH51ExnCY51mPIyIOTgM6Mc849QK4FEyrTqJQE0c5MKmmySFoMTLBnLggr0_cdZsWnI9zZghmzX6BfDAJvPn3Jfpbc5P2hrcQOqb6RnhxR8jp54almsWXoxUQsZlrOsW5bsP2Q5PKk9Q2V0tG9_cfzswxadOSNv8nLf4AhJ2hyg</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Pu, Jia-Le</creator><creator>Xu, Xiao</creator><creator>Chen, Lan-Lan</creator><creator>Li, Chao</creator><creator>Jia, Hang-Dong</creator><creator>Fan, Zhong-Qi</creator><creator>Li, Ju-Dong</creator><creator>Guan, Ming-Cheng</creator><creator>Liang, Ying-Jian</creator><creator>Zhou, Ya-Hao</creator><creator>Wang, Xian-Ming</creator><creator>Gu, Wei-Min</creator><creator>Wang, Hong</creator><creator>Li, Jie</creator><creator>Chen, Zhi-Yu</creator><creator>Chen, Ting-Hao</creator><creator>Zhang, Yao-Ming</creator><creator>Chen, Zi-Xiang</creator><creator>Yao, Lan-Qing</creator><creator>Diao, Yong-Kang</creator><creator>Wang, Ming-Da</creator><creator>Shen, Feng</creator><creator>Pawlik, Timothy M.</creator><creator>Lau, Wan Yee</creator><creator>Chen, Zhong</creator><creator>Yang, Tian</creator><creator>Lv, Guo-Yue</creator><general>Lippincott Williams &amp; Wilkins</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9707-3390</orcidid><orcidid>https://orcid.org/0000-0002-1075-5592</orcidid><orcidid>https://orcid.org/0000-0002-3425-4688</orcidid><orcidid>https://orcid.org/0000-0001-6984-3290</orcidid><orcidid>https://orcid.org/0000-0001-7638-2605</orcidid></search><sort><creationdate>20230801</creationdate><title>Postoperative infectious complications following laparoscopic versus open hepatectomy for hepatocellular carcinoma: a multicenter propensity score analysis of 3876 patients</title><author>Pu, Jia-Le ; Xu, Xiao ; Chen, Lan-Lan ; Li, Chao ; Jia, Hang-Dong ; Fan, Zhong-Qi ; Li, Ju-Dong ; Guan, Ming-Cheng ; Liang, Ying-Jian ; Zhou, Ya-Hao ; Wang, Xian-Ming ; Gu, Wei-Min ; Wang, Hong ; Li, Jie ; Chen, Zhi-Yu ; Chen, Ting-Hao ; Zhang, Yao-Ming ; Chen, Zi-Xiang ; Yao, Lan-Qing ; Diao, Yong-Kang ; Wang, Ming-Da ; Shen, Feng ; Pawlik, Timothy M. ; Lau, Wan Yee ; Chen, Zhong ; Yang, Tian ; Lv, Guo-Yue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-817f4e00e6ddd977eee6f9aef3ddeb53a14309824e38b1e46048bbfea937030f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Original Research</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pu, Jia-Le</creatorcontrib><creatorcontrib>Xu, Xiao</creatorcontrib><creatorcontrib>Chen, Lan-Lan</creatorcontrib><creatorcontrib>Li, Chao</creatorcontrib><creatorcontrib>Jia, Hang-Dong</creatorcontrib><creatorcontrib>Fan, Zhong-Qi</creatorcontrib><creatorcontrib>Li, Ju-Dong</creatorcontrib><creatorcontrib>Guan, Ming-Cheng</creatorcontrib><creatorcontrib>Liang, Ying-Jian</creatorcontrib><creatorcontrib>Zhou, Ya-Hao</creatorcontrib><creatorcontrib>Wang, Xian-Ming</creatorcontrib><creatorcontrib>Gu, Wei-Min</creatorcontrib><creatorcontrib>Wang, Hong</creatorcontrib><creatorcontrib>Li, Jie</creatorcontrib><creatorcontrib>Chen, Zhi-Yu</creatorcontrib><creatorcontrib>Chen, Ting-Hao</creatorcontrib><creatorcontrib>Zhang, Yao-Ming</creatorcontrib><creatorcontrib>Chen, Zi-Xiang</creatorcontrib><creatorcontrib>Yao, Lan-Qing</creatorcontrib><creatorcontrib>Diao, Yong-Kang</creatorcontrib><creatorcontrib>Wang, Ming-Da</creatorcontrib><creatorcontrib>Shen, Feng</creatorcontrib><creatorcontrib>Pawlik, Timothy M.</creatorcontrib><creatorcontrib>Lau, Wan Yee</creatorcontrib><creatorcontrib>Chen, Zhong</creatorcontrib><creatorcontrib>Yang, Tian</creatorcontrib><creatorcontrib>Lv, Guo-Yue</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of surgery (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pu, Jia-Le</au><au>Xu, Xiao</au><au>Chen, Lan-Lan</au><au>Li, Chao</au><au>Jia, Hang-Dong</au><au>Fan, Zhong-Qi</au><au>Li, Ju-Dong</au><au>Guan, Ming-Cheng</au><au>Liang, Ying-Jian</au><au>Zhou, Ya-Hao</au><au>Wang, Xian-Ming</au><au>Gu, Wei-Min</au><au>Wang, Hong</au><au>Li, Jie</au><au>Chen, Zhi-Yu</au><au>Chen, Ting-Hao</au><au>Zhang, Yao-Ming</au><au>Chen, Zi-Xiang</au><au>Yao, Lan-Qing</au><au>Diao, Yong-Kang</au><au>Wang, Ming-Da</au><au>Shen, Feng</au><au>Pawlik, Timothy M.</au><au>Lau, Wan Yee</au><au>Chen, Zhong</au><au>Yang, Tian</au><au>Lv, Guo-Yue</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postoperative infectious complications following laparoscopic versus open hepatectomy for hepatocellular carcinoma: a multicenter propensity score analysis of 3876 patients</atitle><jtitle>International journal of surgery (London, England)</jtitle><date>2023-08-01</date><risdate>2023</risdate><volume>109</volume><issue>8</issue><spage>2267</spage><epage>2275</epage><pages>2267-2275</pages><issn>1743-9159</issn><issn>1743-9191</issn><eissn>1743-9159</eissn><abstract>OBJECTIVESHepatocellular carcinoma (HCC) is a common indication for hepatectomy that is often complicated by postoperative complication. The authors sought to investigate the relationship between the open with laparoscopic approach of hepatectomy and incidences of postoperative infectious complications. PATIENTS AND METHODSUsing a multicenter database, HCC patients who underwent laparoscopic hepatectomy (LH) or open hepatectomy (OH) were reviewed and analyzed. Propensity score matching (PSM), inverse probability of treatment weight (IPTW), and multivariate logistic regression analyses were utilized to assess the association of the operative approach with postoperative infectious complications, including incisional surgical site infection (SSI), organ/space SSI, and remote infection (RI). RESULTSAmong 3876 patients, 845 (21.8%) and 3031 (78.2%) patients underwent LH and OH, respectively. The overall incidence of infection was 6.9 versus 14.6% among patients who underwent LH versus OH, respectively ( P &lt;0.001). Of note, the incidences of incisional SSI (1.8 vs. 6.3%, P &lt;0.001), organ/space SSI (1.8 vs. 4.6%, P &lt;0.001), and RI (3.8 vs. 9.8%, P &lt;0.001) were all significantly lower among patients who underwent LH versus OH. After PSM (6.9, 1.8, 1.8, and 3.8% vs. 18.5, 8.4, 5.2, and 12.8%, respectively) and IPTW (9.5, 2.3, 2.1, and 5.5% vs. 14.3, 6.3, 4.5, and 9.8%, respectively), LH remained associated with statistically lower incidences of all types of infectious complications. After adjustment for other confounding factors on multivariate analyses, LH remained independently associated with lower incidences of overall infection, incisional SSI, organ/space SSI, and RI in the overall, PSM, and IPTW cohorts, respectively. CONCLUSIONCompared with open approach, laparoscopic approach was independently associated with lower incidences of postoperative infectious complications following hepatectomy for HCC.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams &amp; Wilkins</pub><pmid>37161522</pmid><doi>10.1097/JS9.0000000000000446</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9707-3390</orcidid><orcidid>https://orcid.org/0000-0002-1075-5592</orcidid><orcidid>https://orcid.org/0000-0002-3425-4688</orcidid><orcidid>https://orcid.org/0000-0001-6984-3290</orcidid><orcidid>https://orcid.org/0000-0001-7638-2605</orcidid><oa>free_for_read</oa></addata></record>
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title Postoperative infectious complications following laparoscopic versus open hepatectomy for hepatocellular carcinoma: a multicenter propensity score analysis of 3876 patients
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