Postoperative infectious complications following laparoscopic versus open hepatectomy for hepatocellular carcinoma: a multicenter propensity score analysis of 3876 patients
OBJECTIVESHepatocellular carcinoma (HCC) is a common indication for hepatectomy that is often complicated by postoperative complication. The authors sought to investigate the relationship between the open with laparoscopic approach of hepatectomy and incidences of postoperative infectious complicati...
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Veröffentlicht in: | International journal of surgery (London, England) England), 2023-08, Vol.109 (8), p.2267-2275 |
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creator | Pu, Jia-Le Xu, Xiao Chen, Lan-Lan Li, Chao Jia, Hang-Dong Fan, Zhong-Qi Li, Ju-Dong Guan, Ming-Cheng Liang, Ying-Jian Zhou, Ya-Hao Wang, Xian-Ming Gu, Wei-Min Wang, Hong Li, Jie Chen, Zhi-Yu Chen, Ting-Hao Zhang, Yao-Ming Chen, Zi-Xiang Yao, Lan-Qing Diao, Yong-Kang Wang, Ming-Da Shen, Feng Pawlik, Timothy M. Lau, Wan Yee Chen, Zhong Yang, Tian Lv, Guo-Yue |
description | OBJECTIVESHepatocellular carcinoma (HCC) is a common indication for hepatectomy that is often complicated by postoperative complication. The authors sought to investigate the relationship between the open with laparoscopic approach of hepatectomy and incidences of postoperative infectious complications. PATIENTS AND METHODSUsing a multicenter database, HCC patients who underwent laparoscopic hepatectomy (LH) or open hepatectomy (OH) were reviewed and analyzed. Propensity score matching (PSM), inverse probability of treatment weight (IPTW), and multivariate logistic regression analyses were utilized to assess the association of the operative approach with postoperative infectious complications, including incisional surgical site infection (SSI), organ/space SSI, and remote infection (RI). RESULTSAmong 3876 patients, 845 (21.8%) and 3031 (78.2%) patients underwent LH and OH, respectively. The overall incidence of infection was 6.9 versus 14.6% among patients who underwent LH versus OH, respectively ( P |
doi_str_mv | 10.1097/JS9.0000000000000446 |
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fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10442085</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2811938656</sourcerecordid><originalsourceid>FETCH-LOGICAL-c386t-817f4e00e6ddd977eee6f9aef3ddeb53a14309824e38b1e46048bbfea937030f3</originalsourceid><addsrcrecordid>eNpdkc2OFSEQhYnROOPoG7hg6eaO0NDd4MaYib-ZRBN1TarpYgZDQwv0NfedfEi5uRMzygYKTn1UziHkOWeXnOnx5aev-pLdX1IOD8g5H6XYad7rh_fOZ-RJKT-ahCmuHpMzMfKB9113Tn5_SaWmFTNUv0fqo0NbfdoKtWlZg7ftPsVCXQoh_fLxhgZYIadi0-ot3WMuTdsAkd7iCrV1p-XQ5PlUJ4shbAEytZCtj2mBVxTosoXqLcaKma752F58PdBGzUghQjgU37COCjUOtHF805an5JGDUPDZ3X5Bvr97--3qw-768_uPV2-ud1aooe4UH51ExnCY51mPIyIOTgM6Mc849QK4FEyrTqJQE0c5MKmmySFoMTLBnLggr0_cdZsWnI9zZghmzX6BfDAJvPn3Jfpbc5P2hrcQOqb6RnhxR8jp54almsWXoxUQsZlrOsW5bsP2Q5PKk9Q2V0tG9_cfzswxadOSNv8nLf4AhJ2hyg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2811938656</pqid></control><display><type>article</type><title>Postoperative infectious complications following laparoscopic versus open hepatectomy for hepatocellular carcinoma: a multicenter propensity score analysis of 3876 patients</title><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Pu, Jia-Le ; Xu, Xiao ; Chen, Lan-Lan ; Li, Chao ; Jia, Hang-Dong ; Fan, Zhong-Qi ; Li, Ju-Dong ; Guan, Ming-Cheng ; Liang, Ying-Jian ; Zhou, Ya-Hao ; Wang, Xian-Ming ; Gu, Wei-Min ; Wang, Hong ; Li, Jie ; Chen, Zhi-Yu ; Chen, Ting-Hao ; Zhang, Yao-Ming ; Chen, Zi-Xiang ; Yao, Lan-Qing ; Diao, Yong-Kang ; Wang, Ming-Da ; Shen, Feng ; Pawlik, Timothy M. ; Lau, Wan Yee ; Chen, Zhong ; Yang, Tian ; Lv, Guo-Yue</creator><creatorcontrib>Pu, Jia-Le ; Xu, Xiao ; Chen, Lan-Lan ; Li, Chao ; Jia, Hang-Dong ; Fan, Zhong-Qi ; Li, Ju-Dong ; Guan, Ming-Cheng ; Liang, Ying-Jian ; Zhou, Ya-Hao ; Wang, Xian-Ming ; Gu, Wei-Min ; Wang, Hong ; Li, Jie ; Chen, Zhi-Yu ; Chen, Ting-Hao ; Zhang, Yao-Ming ; Chen, Zi-Xiang ; Yao, Lan-Qing ; Diao, Yong-Kang ; Wang, Ming-Da ; Shen, Feng ; Pawlik, Timothy M. ; Lau, Wan Yee ; Chen, Zhong ; Yang, Tian ; Lv, Guo-Yue</creatorcontrib><description>OBJECTIVESHepatocellular carcinoma (HCC) is a common indication for hepatectomy that is often complicated by postoperative complication. The authors sought to investigate the relationship between the open with laparoscopic approach of hepatectomy and incidences of postoperative infectious complications. PATIENTS AND METHODSUsing a multicenter database, HCC patients who underwent laparoscopic hepatectomy (LH) or open hepatectomy (OH) were reviewed and analyzed. Propensity score matching (PSM), inverse probability of treatment weight (IPTW), and multivariate logistic regression analyses were utilized to assess the association of the operative approach with postoperative infectious complications, including incisional surgical site infection (SSI), organ/space SSI, and remote infection (RI). RESULTSAmong 3876 patients, 845 (21.8%) and 3031 (78.2%) patients underwent LH and OH, respectively. The overall incidence of infection was 6.9 versus 14.6% among patients who underwent LH versus OH, respectively ( P <0.001). Of note, the incidences of incisional SSI (1.8 vs. 6.3%, P <0.001), organ/space SSI (1.8 vs. 4.6%, P <0.001), and RI (3.8 vs. 9.8%, P <0.001) were all significantly lower among patients who underwent LH versus OH. After PSM (6.9, 1.8, 1.8, and 3.8% vs. 18.5, 8.4, 5.2, and 12.8%, respectively) and IPTW (9.5, 2.3, 2.1, and 5.5% vs. 14.3, 6.3, 4.5, and 9.8%, respectively), LH remained associated with statistically lower incidences of all types of infectious complications. After adjustment for other confounding factors on multivariate analyses, LH remained independently associated with lower incidences of overall infection, incisional SSI, organ/space SSI, and RI in the overall, PSM, and IPTW cohorts, respectively. CONCLUSIONCompared with open approach, laparoscopic approach was independently associated with lower incidences of postoperative infectious complications following hepatectomy for HCC.</description><identifier>ISSN: 1743-9159</identifier><identifier>ISSN: 1743-9191</identifier><identifier>EISSN: 1743-9159</identifier><identifier>DOI: 10.1097/JS9.0000000000000446</identifier><identifier>PMID: 37161522</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Original Research</subject><ispartof>International journal of surgery (London, England), 2023-08, Vol.109 (8), p.2267-2275</ispartof><rights>Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-817f4e00e6ddd977eee6f9aef3ddeb53a14309824e38b1e46048bbfea937030f3</citedby><cites>FETCH-LOGICAL-c386t-817f4e00e6ddd977eee6f9aef3ddeb53a14309824e38b1e46048bbfea937030f3</cites><orcidid>0000-0002-9707-3390 ; 0000-0002-1075-5592 ; 0000-0002-3425-4688 ; 0000-0001-6984-3290 ; 0000-0001-7638-2605</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,865,886,27928,27929</link.rule.ids></links><search><creatorcontrib>Pu, Jia-Le</creatorcontrib><creatorcontrib>Xu, Xiao</creatorcontrib><creatorcontrib>Chen, Lan-Lan</creatorcontrib><creatorcontrib>Li, Chao</creatorcontrib><creatorcontrib>Jia, Hang-Dong</creatorcontrib><creatorcontrib>Fan, Zhong-Qi</creatorcontrib><creatorcontrib>Li, Ju-Dong</creatorcontrib><creatorcontrib>Guan, Ming-Cheng</creatorcontrib><creatorcontrib>Liang, Ying-Jian</creatorcontrib><creatorcontrib>Zhou, Ya-Hao</creatorcontrib><creatorcontrib>Wang, Xian-Ming</creatorcontrib><creatorcontrib>Gu, Wei-Min</creatorcontrib><creatorcontrib>Wang, Hong</creatorcontrib><creatorcontrib>Li, Jie</creatorcontrib><creatorcontrib>Chen, Zhi-Yu</creatorcontrib><creatorcontrib>Chen, Ting-Hao</creatorcontrib><creatorcontrib>Zhang, Yao-Ming</creatorcontrib><creatorcontrib>Chen, Zi-Xiang</creatorcontrib><creatorcontrib>Yao, Lan-Qing</creatorcontrib><creatorcontrib>Diao, Yong-Kang</creatorcontrib><creatorcontrib>Wang, Ming-Da</creatorcontrib><creatorcontrib>Shen, Feng</creatorcontrib><creatorcontrib>Pawlik, Timothy M.</creatorcontrib><creatorcontrib>Lau, Wan Yee</creatorcontrib><creatorcontrib>Chen, Zhong</creatorcontrib><creatorcontrib>Yang, Tian</creatorcontrib><creatorcontrib>Lv, Guo-Yue</creatorcontrib><title>Postoperative infectious complications following laparoscopic versus open hepatectomy for hepatocellular carcinoma: a multicenter propensity score analysis of 3876 patients</title><title>International journal of surgery (London, England)</title><description>OBJECTIVESHepatocellular carcinoma (HCC) is a common indication for hepatectomy that is often complicated by postoperative complication. The authors sought to investigate the relationship between the open with laparoscopic approach of hepatectomy and incidences of postoperative infectious complications. PATIENTS AND METHODSUsing a multicenter database, HCC patients who underwent laparoscopic hepatectomy (LH) or open hepatectomy (OH) were reviewed and analyzed. Propensity score matching (PSM), inverse probability of treatment weight (IPTW), and multivariate logistic regression analyses were utilized to assess the association of the operative approach with postoperative infectious complications, including incisional surgical site infection (SSI), organ/space SSI, and remote infection (RI). RESULTSAmong 3876 patients, 845 (21.8%) and 3031 (78.2%) patients underwent LH and OH, respectively. The overall incidence of infection was 6.9 versus 14.6% among patients who underwent LH versus OH, respectively ( P <0.001). Of note, the incidences of incisional SSI (1.8 vs. 6.3%, P <0.001), organ/space SSI (1.8 vs. 4.6%, P <0.001), and RI (3.8 vs. 9.8%, P <0.001) were all significantly lower among patients who underwent LH versus OH. After PSM (6.9, 1.8, 1.8, and 3.8% vs. 18.5, 8.4, 5.2, and 12.8%, respectively) and IPTW (9.5, 2.3, 2.1, and 5.5% vs. 14.3, 6.3, 4.5, and 9.8%, respectively), LH remained associated with statistically lower incidences of all types of infectious complications. After adjustment for other confounding factors on multivariate analyses, LH remained independently associated with lower incidences of overall infection, incisional SSI, organ/space SSI, and RI in the overall, PSM, and IPTW cohorts, respectively. CONCLUSIONCompared with open approach, laparoscopic approach was independently associated with lower incidences of postoperative infectious complications following hepatectomy for HCC.</description><subject>Original Research</subject><issn>1743-9159</issn><issn>1743-9191</issn><issn>1743-9159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkc2OFSEQhYnROOPoG7hg6eaO0NDd4MaYib-ZRBN1TarpYgZDQwv0NfedfEi5uRMzygYKTn1UziHkOWeXnOnx5aev-pLdX1IOD8g5H6XYad7rh_fOZ-RJKT-ahCmuHpMzMfKB9113Tn5_SaWmFTNUv0fqo0NbfdoKtWlZg7ftPsVCXQoh_fLxhgZYIadi0-ot3WMuTdsAkd7iCrV1p-XQ5PlUJ4shbAEytZCtj2mBVxTosoXqLcaKma752F58PdBGzUghQjgU37COCjUOtHF805an5JGDUPDZ3X5Bvr97--3qw-768_uPV2-ud1aooe4UH51ExnCY51mPIyIOTgM6Mc849QK4FEyrTqJQE0c5MKmmySFoMTLBnLggr0_cdZsWnI9zZghmzX6BfDAJvPn3Jfpbc5P2hrcQOqb6RnhxR8jp54almsWXoxUQsZlrOsW5bsP2Q5PKk9Q2V0tG9_cfzswxadOSNv8nLf4AhJ2hyg</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Pu, Jia-Le</creator><creator>Xu, Xiao</creator><creator>Chen, Lan-Lan</creator><creator>Li, Chao</creator><creator>Jia, Hang-Dong</creator><creator>Fan, Zhong-Qi</creator><creator>Li, Ju-Dong</creator><creator>Guan, Ming-Cheng</creator><creator>Liang, Ying-Jian</creator><creator>Zhou, Ya-Hao</creator><creator>Wang, Xian-Ming</creator><creator>Gu, Wei-Min</creator><creator>Wang, Hong</creator><creator>Li, Jie</creator><creator>Chen, Zhi-Yu</creator><creator>Chen, Ting-Hao</creator><creator>Zhang, Yao-Ming</creator><creator>Chen, Zi-Xiang</creator><creator>Yao, Lan-Qing</creator><creator>Diao, Yong-Kang</creator><creator>Wang, Ming-Da</creator><creator>Shen, Feng</creator><creator>Pawlik, Timothy M.</creator><creator>Lau, Wan Yee</creator><creator>Chen, Zhong</creator><creator>Yang, Tian</creator><creator>Lv, Guo-Yue</creator><general>Lippincott Williams & Wilkins</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9707-3390</orcidid><orcidid>https://orcid.org/0000-0002-1075-5592</orcidid><orcidid>https://orcid.org/0000-0002-3425-4688</orcidid><orcidid>https://orcid.org/0000-0001-6984-3290</orcidid><orcidid>https://orcid.org/0000-0001-7638-2605</orcidid></search><sort><creationdate>20230801</creationdate><title>Postoperative infectious complications following laparoscopic versus open hepatectomy for hepatocellular carcinoma: a multicenter propensity score analysis of 3876 patients</title><author>Pu, Jia-Le ; Xu, Xiao ; Chen, Lan-Lan ; Li, Chao ; Jia, Hang-Dong ; Fan, Zhong-Qi ; Li, Ju-Dong ; Guan, Ming-Cheng ; Liang, Ying-Jian ; Zhou, Ya-Hao ; Wang, Xian-Ming ; Gu, Wei-Min ; Wang, Hong ; Li, Jie ; Chen, Zhi-Yu ; Chen, Ting-Hao ; Zhang, Yao-Ming ; Chen, Zi-Xiang ; Yao, Lan-Qing ; Diao, Yong-Kang ; Wang, Ming-Da ; Shen, Feng ; Pawlik, Timothy M. ; Lau, Wan Yee ; Chen, Zhong ; Yang, Tian ; Lv, Guo-Yue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-817f4e00e6ddd977eee6f9aef3ddeb53a14309824e38b1e46048bbfea937030f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Original Research</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pu, Jia-Le</creatorcontrib><creatorcontrib>Xu, Xiao</creatorcontrib><creatorcontrib>Chen, Lan-Lan</creatorcontrib><creatorcontrib>Li, Chao</creatorcontrib><creatorcontrib>Jia, Hang-Dong</creatorcontrib><creatorcontrib>Fan, Zhong-Qi</creatorcontrib><creatorcontrib>Li, Ju-Dong</creatorcontrib><creatorcontrib>Guan, Ming-Cheng</creatorcontrib><creatorcontrib>Liang, Ying-Jian</creatorcontrib><creatorcontrib>Zhou, Ya-Hao</creatorcontrib><creatorcontrib>Wang, Xian-Ming</creatorcontrib><creatorcontrib>Gu, Wei-Min</creatorcontrib><creatorcontrib>Wang, Hong</creatorcontrib><creatorcontrib>Li, Jie</creatorcontrib><creatorcontrib>Chen, Zhi-Yu</creatorcontrib><creatorcontrib>Chen, Ting-Hao</creatorcontrib><creatorcontrib>Zhang, Yao-Ming</creatorcontrib><creatorcontrib>Chen, Zi-Xiang</creatorcontrib><creatorcontrib>Yao, Lan-Qing</creatorcontrib><creatorcontrib>Diao, Yong-Kang</creatorcontrib><creatorcontrib>Wang, Ming-Da</creatorcontrib><creatorcontrib>Shen, Feng</creatorcontrib><creatorcontrib>Pawlik, Timothy M.</creatorcontrib><creatorcontrib>Lau, Wan Yee</creatorcontrib><creatorcontrib>Chen, Zhong</creatorcontrib><creatorcontrib>Yang, Tian</creatorcontrib><creatorcontrib>Lv, Guo-Yue</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of surgery (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pu, Jia-Le</au><au>Xu, Xiao</au><au>Chen, Lan-Lan</au><au>Li, Chao</au><au>Jia, Hang-Dong</au><au>Fan, Zhong-Qi</au><au>Li, Ju-Dong</au><au>Guan, Ming-Cheng</au><au>Liang, Ying-Jian</au><au>Zhou, Ya-Hao</au><au>Wang, Xian-Ming</au><au>Gu, Wei-Min</au><au>Wang, Hong</au><au>Li, Jie</au><au>Chen, Zhi-Yu</au><au>Chen, Ting-Hao</au><au>Zhang, Yao-Ming</au><au>Chen, Zi-Xiang</au><au>Yao, Lan-Qing</au><au>Diao, Yong-Kang</au><au>Wang, Ming-Da</au><au>Shen, Feng</au><au>Pawlik, Timothy M.</au><au>Lau, Wan Yee</au><au>Chen, Zhong</au><au>Yang, Tian</au><au>Lv, Guo-Yue</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postoperative infectious complications following laparoscopic versus open hepatectomy for hepatocellular carcinoma: a multicenter propensity score analysis of 3876 patients</atitle><jtitle>International journal of surgery (London, England)</jtitle><date>2023-08-01</date><risdate>2023</risdate><volume>109</volume><issue>8</issue><spage>2267</spage><epage>2275</epage><pages>2267-2275</pages><issn>1743-9159</issn><issn>1743-9191</issn><eissn>1743-9159</eissn><abstract>OBJECTIVESHepatocellular carcinoma (HCC) is a common indication for hepatectomy that is often complicated by postoperative complication. The authors sought to investigate the relationship between the open with laparoscopic approach of hepatectomy and incidences of postoperative infectious complications. PATIENTS AND METHODSUsing a multicenter database, HCC patients who underwent laparoscopic hepatectomy (LH) or open hepatectomy (OH) were reviewed and analyzed. Propensity score matching (PSM), inverse probability of treatment weight (IPTW), and multivariate logistic regression analyses were utilized to assess the association of the operative approach with postoperative infectious complications, including incisional surgical site infection (SSI), organ/space SSI, and remote infection (RI). RESULTSAmong 3876 patients, 845 (21.8%) and 3031 (78.2%) patients underwent LH and OH, respectively. The overall incidence of infection was 6.9 versus 14.6% among patients who underwent LH versus OH, respectively ( P <0.001). Of note, the incidences of incisional SSI (1.8 vs. 6.3%, P <0.001), organ/space SSI (1.8 vs. 4.6%, P <0.001), and RI (3.8 vs. 9.8%, P <0.001) were all significantly lower among patients who underwent LH versus OH. After PSM (6.9, 1.8, 1.8, and 3.8% vs. 18.5, 8.4, 5.2, and 12.8%, respectively) and IPTW (9.5, 2.3, 2.1, and 5.5% vs. 14.3, 6.3, 4.5, and 9.8%, respectively), LH remained associated with statistically lower incidences of all types of infectious complications. After adjustment for other confounding factors on multivariate analyses, LH remained independently associated with lower incidences of overall infection, incisional SSI, organ/space SSI, and RI in the overall, PSM, and IPTW cohorts, respectively. CONCLUSIONCompared with open approach, laparoscopic approach was independently associated with lower incidences of postoperative infectious complications following hepatectomy for HCC.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>37161522</pmid><doi>10.1097/JS9.0000000000000446</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9707-3390</orcidid><orcidid>https://orcid.org/0000-0002-1075-5592</orcidid><orcidid>https://orcid.org/0000-0002-3425-4688</orcidid><orcidid>https://orcid.org/0000-0001-6984-3290</orcidid><orcidid>https://orcid.org/0000-0001-7638-2605</orcidid><oa>free_for_read</oa></addata></record> |
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title | Postoperative infectious complications following laparoscopic versus open hepatectomy for hepatocellular carcinoma: a multicenter propensity score analysis of 3876 patients |
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