Naringin and naringenin counteract taxol-induced liver injury in Wistar rats via suppression of oxidative stress, apoptosis and inflammation
This research aimed to evaluate the preventing effects of naringin, naringenin, and their combination on liver injury induced by Taxol (paclitaxel) in Wistar rats. Male Wistar rats received 2 mg/kg Taxol intraperitoneal injections twice weekly on the second and fifth days of each week for 6 weeks. D...
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| Veröffentlicht in: | Environmental science and pollution research international 2023-08, Vol.30 (39), p.90892-90905 |
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| creator | Khaled, Shimaa S. Soliman, Hanan A. Abdel-Gabbar, Mohammed Ahmed, Noha A. El-Nahass, El-Shaymaa Ahmed, Osama M. |
| description | This research aimed to evaluate the preventing effects of naringin, naringenin, and their combination on liver injury induced by Taxol (paclitaxel) in Wistar rats. Male Wistar rats received 2 mg/kg Taxol intraperitoneal injections twice weekly on the second and fifth days of each week for 6 weeks. During the same period as Taxol administration, rats were given naringin, naringenin, or a combination of the two (10 mg/kg b.wt) every other day. Treatment with naringin and/or naringenin reduced the abnormally high serum levels of total bilirubin, aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and gamma-glutamyl transferase in Taxol-treated rats. It also significantly increased the level of serum albumin, indicating an improvement in the liver. The perturbed histological liver changes were markedly improved due to the naringin and/or naringenin treatment in Taxol-administered rats. Additionally, the treatments reduced high hepatic lipid peroxidation and increased liver glutathione content as well as the activities of superoxide dismutase and glutathione peroxidase. Furthermore, the treatments reduced the levels of alpha-fetoprotein and caspase-3, a pro-apoptotic mediator. The naringin and naringenin mixture appeared more effective in improving organ function and structural integrity. In conclusion, naringin and naringenin are suggested to employ their hepatoprotective benefits via boosting the body’s antioxidant defense system, reducing inflammation, and suppressing apoptosis.
Graphical Abstract |
| doi_str_mv | 10.1007/s11356-023-28454-4 |
| format | Article |
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The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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Male Wistar rats received 2 mg/kg Taxol intraperitoneal injections twice weekly on the second and fifth days of each week for 6 weeks. During the same period as Taxol administration, rats were given naringin, naringenin, or a combination of the two (10 mg/kg b.wt) every other day. Treatment with naringin and/or naringenin reduced the abnormally high serum levels of total bilirubin, aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and gamma-glutamyl transferase in Taxol-treated rats. It also significantly increased the level of serum albumin, indicating an improvement in the liver. The perturbed histological liver changes were markedly improved due to the naringin and/or naringenin treatment in Taxol-administered rats. Additionally, the treatments reduced high hepatic lipid peroxidation and increased liver glutathione content as well as the activities of superoxide dismutase and glutathione peroxidase. Furthermore, the treatments reduced the levels of alpha-fetoprotein and caspase-3, a pro-apoptotic mediator. The naringin and naringenin mixture appeared more effective in improving organ function and structural integrity. In conclusion, naringin and naringenin are suggested to employ their hepatoprotective benefits via boosting the body’s antioxidant defense system, reducing inflammation, and suppressing apoptosis.
Graphical Abstract</description><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Alanine Transaminase - metabolism</subject><subject>Alkaline phosphatase</subject><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Antioxidants - pharmacology</subject><subject>Apoptosis</subject><subject>Aquatic Pollution</subject><subject>Aspartate transaminase</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Bilirubin</subject><subject>Caspase-3</subject><subject>Chemical and Drug Induced Liver Injury - metabolism</subject><subject>Chemical and Drug Induced Liver Injury, Chronic - metabolism</subject><subject>Chemical and Drug Induced Liver Injury, Chronic - pathology</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Glutathione</subject><subject>Glutathione peroxidase</subject><subject>Inflammation</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - metabolism</subject><subject>Injury prevention</subject><subject>L-Lactate dehydrogenase</subject><subject>Lactate dehydrogenase</subject><subject>Lipid Peroxidation</subject><subject>Lipids</subject><subject>Liver</subject><subject>Male</subject><subject>Naringenin</subject><subject>Oxidation</subject><subject>Oxidative Stress</subject><subject>Paclitaxel</subject><subject>Paclitaxel - metabolism</subject><subject>Paclitaxel - toxicity</subject><subject>Peroxidase</subject><subject>Peroxidation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Research Article</subject><subject>Serum albumin</subject><subject>Serum levels</subject><subject>Structural integrity</subject><subject>Superoxide dismutase</subject><subject>Taxol</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><subject>α-Fetoprotein</subject><subject>γ-Glutamyltransferase</subject><issn>1614-7499</issn><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUtuFDEQhluIiITABVggS2xY0MGvbtsrFEW8pChsQCytGrcdPOq2G9s9Sg7BHTgLJ8Mzk4TAglW5yl_95fLfNM8IPiEYi9eZENb1LaaspZJ3vOUPmiPSE94KrtTDe-fD5nHOa4wpVlQ8ag6Z4H0vmTpqflxA8uHSBwRhQGGX2FBTE5dQbAJTUIGrOLY-DIuxAxr9xibkw3pJ1zWgrz4XSChByWjjAeVlnpPN2ceAokPxyg9Qag_KZVt-hWCOc4nZ5-3IXz99cCNMU2VieNIcOBizfXoTj5sv795-PvvQnn96__Hs9Lw1XHSlVUIClR0GC10nFVVDB4wTKleYCQyOOCkoJtxJZ4zojbKcKzCwwoIP1Al23LzZ687LarKDsaEkGPWc_ATpWkfw-u-b4L_py7jRBHOmJN8qvLxRSPH7YnPRk8_GjiMEG5esaf1dwbGgpKIv_kHXcUmh7lepjhHGFFGVonvKpJhzsu7uNQTrrd16b7euduud3ZrXpuf397hrufW3AmwP5HnnbPoz-z-yvwGFZbqU</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Khaled, Shimaa S.</creator><creator>Soliman, Hanan A.</creator><creator>Abdel-Gabbar, Mohammed</creator><creator>Ahmed, Noha A.</creator><creator>El-Nahass, El-Shaymaa</creator><creator>Ahmed, Osama M.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SN</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>P64</scope><scope>PATMY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5080-0933</orcidid></search><sort><creationdate>20230801</creationdate><title>Naringin and naringenin counteract taxol-induced liver injury in Wistar rats via suppression of oxidative stress, apoptosis and inflammation</title><author>Khaled, Shimaa S. ; Soliman, Hanan A. ; Abdel-Gabbar, Mohammed ; Ahmed, Noha A. ; El-Nahass, El-Shaymaa ; Ahmed, Osama M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-978a2850aea558929d5a34128b0370af1f872014f8fcc76c9e449acab074d2f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Alanine Transaminase - metabolism</topic><topic>Alkaline phosphatase</topic><topic>Animals</topic><topic>Antioxidants - metabolism</topic><topic>Antioxidants - pharmacology</topic><topic>Apoptosis</topic><topic>Aquatic Pollution</topic><topic>Aspartate transaminase</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Bilirubin</topic><topic>Caspase-3</topic><topic>Chemical and Drug Induced Liver Injury - metabolism</topic><topic>Chemical and Drug Induced Liver Injury, Chronic - metabolism</topic><topic>Chemical and Drug Induced Liver Injury, Chronic - pathology</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Environmental science</topic><topic>Glutathione</topic><topic>Glutathione peroxidase</topic><topic>Inflammation</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - metabolism</topic><topic>Injury prevention</topic><topic>L-Lactate dehydrogenase</topic><topic>Lactate dehydrogenase</topic><topic>Lipid Peroxidation</topic><topic>Lipids</topic><topic>Liver</topic><topic>Male</topic><topic>Naringenin</topic><topic>Oxidation</topic><topic>Oxidative Stress</topic><topic>Paclitaxel</topic><topic>Paclitaxel - metabolism</topic><topic>Paclitaxel - toxicity</topic><topic>Peroxidase</topic><topic>Peroxidation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Research Article</topic><topic>Serum albumin</topic><topic>Serum levels</topic><topic>Structural integrity</topic><topic>Superoxide dismutase</topic><topic>Taxol</topic><topic>Waste Water Technology</topic><topic>Water Management</topic><topic>Water Pollution Control</topic><topic>α-Fetoprotein</topic><topic>γ-Glutamyltransferase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khaled, Shimaa S.</creatorcontrib><creatorcontrib>Soliman, Hanan A.</creatorcontrib><creatorcontrib>Abdel-Gabbar, Mohammed</creatorcontrib><creatorcontrib>Ahmed, Noha A.</creatorcontrib><creatorcontrib>El-Nahass, El-Shaymaa</creatorcontrib><creatorcontrib>Ahmed, Osama M.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ecology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Access via ABI/INFORM (ProQuest)</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ABI/INFORM Global</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khaled, Shimaa S.</au><au>Soliman, Hanan A.</au><au>Abdel-Gabbar, Mohammed</au><au>Ahmed, Noha A.</au><au>El-Nahass, El-Shaymaa</au><au>Ahmed, Osama M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Naringin and naringenin counteract taxol-induced liver injury in Wistar rats via suppression of oxidative stress, apoptosis and inflammation</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>30</volume><issue>39</issue><spage>90892</spage><epage>90905</epage><pages>90892-90905</pages><issn>1614-7499</issn><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>This research aimed to evaluate the preventing effects of naringin, naringenin, and their combination on liver injury induced by Taxol (paclitaxel) in Wistar rats. Male Wistar rats received 2 mg/kg Taxol intraperitoneal injections twice weekly on the second and fifth days of each week for 6 weeks. During the same period as Taxol administration, rats were given naringin, naringenin, or a combination of the two (10 mg/kg b.wt) every other day. Treatment with naringin and/or naringenin reduced the abnormally high serum levels of total bilirubin, aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and gamma-glutamyl transferase in Taxol-treated rats. It also significantly increased the level of serum albumin, indicating an improvement in the liver. The perturbed histological liver changes were markedly improved due to the naringin and/or naringenin treatment in Taxol-administered rats. Additionally, the treatments reduced high hepatic lipid peroxidation and increased liver glutathione content as well as the activities of superoxide dismutase and glutathione peroxidase. Furthermore, the treatments reduced the levels of alpha-fetoprotein and caspase-3, a pro-apoptotic mediator. The naringin and naringenin mixture appeared more effective in improving organ function and structural integrity. In conclusion, naringin and naringenin are suggested to employ their hepatoprotective benefits via boosting the body’s antioxidant defense system, reducing inflammation, and suppressing apoptosis.
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| ispartof | Environmental science and pollution research international, 2023-08, Vol.30 (39), p.90892-90905 |
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| language | eng |
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| subjects | Alanine Alanine transaminase Alanine Transaminase - metabolism Alkaline phosphatase Animals Antioxidants - metabolism Antioxidants - pharmacology Apoptosis Aquatic Pollution Aspartate transaminase Atmospheric Protection/Air Quality Control/Air Pollution Bilirubin Caspase-3 Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury, Chronic - metabolism Chemical and Drug Induced Liver Injury, Chronic - pathology Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Glutathione Glutathione peroxidase Inflammation Inflammation - chemically induced Inflammation - metabolism Injury prevention L-Lactate dehydrogenase Lactate dehydrogenase Lipid Peroxidation Lipids Liver Male Naringenin Oxidation Oxidative Stress Paclitaxel Paclitaxel - metabolism Paclitaxel - toxicity Peroxidase Peroxidation Rats Rats, Wistar Research Article Serum albumin Serum levels Structural integrity Superoxide dismutase Taxol Waste Water Technology Water Management Water Pollution Control α-Fetoprotein γ-Glutamyltransferase |
| title | Naringin and naringenin counteract taxol-induced liver injury in Wistar rats via suppression of oxidative stress, apoptosis and inflammation |
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