Cognitive functioning in postural orthostatic tachycardia syndrome among different body positions: a prospective pilot study (POTSKog study)

Purpose Approximately 96% of patients with postural orthostatic tachycardia syndrome (PoTS) report cognitive complaints. We investigated whether cognitive function is impaired during sitting and active standing in 30 patients with PoTS compared with 30 healthy controls (HCs) and whether it will impr...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Clinical autonomic research 2023-08, Vol.33 (4), p.459-468
Hauptverfasser: Maier, Andrea, Schopen, Lena, Thiel, Joana C., Müller, Katharina, Fimm, Bruno, Schulz, Jörg B.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 468
container_issue 4
container_start_page 459
container_title Clinical autonomic research
container_volume 33
creator Maier, Andrea
Schopen, Lena
Thiel, Joana C.
Müller, Katharina
Fimm, Bruno
Schulz, Jörg B.
description Purpose Approximately 96% of patients with postural orthostatic tachycardia syndrome (PoTS) report cognitive complaints. We investigated whether cognitive function is impaired during sitting and active standing in 30 patients with PoTS compared with 30 healthy controls (HCs) and whether it will improve with the counter manoeuvre of leg crossing. Methods In this prospective pilot study, patients with PoTS were compared to HCs matched for age, sex, and educational level. Baseline data included norepinephrine plasma levels, autonomic testing and baseline cognitive function in a seated position [the Montreal Cognitive Assessment, the Leistungsprüfsystem (LPS) subtests 1 and 2, and the Test of Attentional Performance (TAP)]. Cognitive functioning was examined in a randomized order in supine, upright and upright legs crossed position. The primary outcomes were the cognitive test scores between HCs and patients with PoTS at baseline testing, and among the different body positions. Results Patients with PoTS had impaired attention (TAP median reaction time) in the seated position and impaired executive functioning (Stroop) while standing compared with HC. Stroop was influenced by position (supine versus upright versus upright legs crossed) only in the PoTS group. Leg crossing did not result in an improvement in executive function. In patients with PoTS, there was a negative correlation of Stroop with norepinephrine plasma levels while standing. Conclusion Compared with HCs, PoTS participants showed impaired cognitive attention and executive function in the upright position that did not improve in the legs crossed position. Data provide further evidence for orthostatic cognitive deterioration in patients with PoTS. Trial Registration Information The study was registered at ClinicalTrials.gov (NCT03681080).
doi_str_mv 10.1007/s10286-023-00950-0
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10439038</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2853052389</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-9f25b0ba699f25b16c7f137bc9c34245425385dd81bd3873feb0aaa98b0c72673</originalsourceid><addsrcrecordid>eNp9Uctu1DAUtRCITgs_wAJZYtMuAn7Ejs0GoREvUalIlLXlOE7GVWIH26k0_8BH45mU8liw8rXvOefe4wPAM4xeYoSaVwkjIniFCK0QkgxV6AHYYI5lhRlHD8GmPMpKCoZPwGlKNwhhJih-DE5oQzjmlG_Aj20YvMvu1sJ-8Sa74J0foPNwDikvUY8wxLwrtc7OwKzNbm907JyGae-7GCYL9RQKpXN9b6P1Gbah2x_o7qCWXkMN5xjSbM1xzOzGkGHRLqDzL1fXXz-HYb1ePAGPej0m-_TuPAPf3r-73n6sLq8-fNq-vaxMTXiuZE9Yi1rN5bHC3DQ9pk1rpKE1qVlNGBWs6wRuOyoa2tsWaa2laJEpxht6Bt6suvPSTrYzZeliVM3RTTruVdBO_d3xbqeGcKswqqlEVBSF8zuFGL4vNmU1uWTsOGpvw5IUEQTzGgt5gL74B3oTluiLv4JiFDFChSwosqJM-aoUbX-_DUbqkLZa01YlbXVMW6FCev6nj3vKr3gLgK6AVFp-sPH37P_I_gQfE7j3</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2853052389</pqid></control><display><type>article</type><title>Cognitive functioning in postural orthostatic tachycardia syndrome among different body positions: a prospective pilot study (POTSKog study)</title><source>SpringerNature Journals</source><creator>Maier, Andrea ; Schopen, Lena ; Thiel, Joana C. ; Müller, Katharina ; Fimm, Bruno ; Schulz, Jörg B.</creator><creatorcontrib>Maier, Andrea ; Schopen, Lena ; Thiel, Joana C. ; Müller, Katharina ; Fimm, Bruno ; Schulz, Jörg B.</creatorcontrib><description>Purpose Approximately 96% of patients with postural orthostatic tachycardia syndrome (PoTS) report cognitive complaints. We investigated whether cognitive function is impaired during sitting and active standing in 30 patients with PoTS compared with 30 healthy controls (HCs) and whether it will improve with the counter manoeuvre of leg crossing. Methods In this prospective pilot study, patients with PoTS were compared to HCs matched for age, sex, and educational level. Baseline data included norepinephrine plasma levels, autonomic testing and baseline cognitive function in a seated position [the Montreal Cognitive Assessment, the Leistungsprüfsystem (LPS) subtests 1 and 2, and the Test of Attentional Performance (TAP)]. Cognitive functioning was examined in a randomized order in supine, upright and upright legs crossed position. The primary outcomes were the cognitive test scores between HCs and patients with PoTS at baseline testing, and among the different body positions. Results Patients with PoTS had impaired attention (TAP median reaction time) in the seated position and impaired executive functioning (Stroop) while standing compared with HC. Stroop was influenced by position (supine versus upright versus upright legs crossed) only in the PoTS group. Leg crossing did not result in an improvement in executive function. In patients with PoTS, there was a negative correlation of Stroop with norepinephrine plasma levels while standing. Conclusion Compared with HCs, PoTS participants showed impaired cognitive attention and executive function in the upright position that did not improve in the legs crossed position. Data provide further evidence for orthostatic cognitive deterioration in patients with PoTS. Trial Registration Information The study was registered at ClinicalTrials.gov (NCT03681080).</description><identifier>ISSN: 0959-9851</identifier><identifier>EISSN: 1619-1560</identifier><identifier>DOI: 10.1007/s10286-023-00950-0</identifier><identifier>PMID: 37261636</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cardiac arrhythmia ; Cardiology ; Cognitive ability ; Diabetes ; Endocrinology ; Executive function ; Gastroenterology ; Leg ; Medicine ; Medicine &amp; Public Health ; NCT ; NCT03681080 ; Neurology ; Norepinephrine ; Ophthalmology ; Pilot projects ; Plasma levels ; Posture ; Research Article ; Tachycardia</subject><ispartof>Clinical autonomic research, 2023-08, Vol.33 (4), p.459-468</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c426t-9f25b0ba699f25b16c7f137bc9c34245425385dd81bd3873feb0aaa98b0c72673</cites><orcidid>0000-0002-3427-4806 ; 0000-0002-8903-0593 ; 0000-0002-5818-9526</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10286-023-00950-0$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10286-023-00950-0$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37261636$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maier, Andrea</creatorcontrib><creatorcontrib>Schopen, Lena</creatorcontrib><creatorcontrib>Thiel, Joana C.</creatorcontrib><creatorcontrib>Müller, Katharina</creatorcontrib><creatorcontrib>Fimm, Bruno</creatorcontrib><creatorcontrib>Schulz, Jörg B.</creatorcontrib><title>Cognitive functioning in postural orthostatic tachycardia syndrome among different body positions: a prospective pilot study (POTSKog study)</title><title>Clinical autonomic research</title><addtitle>Clin Auton Res</addtitle><addtitle>Clin Auton Res</addtitle><description>Purpose Approximately 96% of patients with postural orthostatic tachycardia syndrome (PoTS) report cognitive complaints. We investigated whether cognitive function is impaired during sitting and active standing in 30 patients with PoTS compared with 30 healthy controls (HCs) and whether it will improve with the counter manoeuvre of leg crossing. Methods In this prospective pilot study, patients with PoTS were compared to HCs matched for age, sex, and educational level. Baseline data included norepinephrine plasma levels, autonomic testing and baseline cognitive function in a seated position [the Montreal Cognitive Assessment, the Leistungsprüfsystem (LPS) subtests 1 and 2, and the Test of Attentional Performance (TAP)]. Cognitive functioning was examined in a randomized order in supine, upright and upright legs crossed position. The primary outcomes were the cognitive test scores between HCs and patients with PoTS at baseline testing, and among the different body positions. Results Patients with PoTS had impaired attention (TAP median reaction time) in the seated position and impaired executive functioning (Stroop) while standing compared with HC. Stroop was influenced by position (supine versus upright versus upright legs crossed) only in the PoTS group. Leg crossing did not result in an improvement in executive function. In patients with PoTS, there was a negative correlation of Stroop with norepinephrine plasma levels while standing. Conclusion Compared with HCs, PoTS participants showed impaired cognitive attention and executive function in the upright position that did not improve in the legs crossed position. Data provide further evidence for orthostatic cognitive deterioration in patients with PoTS. Trial Registration Information The study was registered at ClinicalTrials.gov (NCT03681080).</description><subject>Cardiac arrhythmia</subject><subject>Cardiology</subject><subject>Cognitive ability</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Executive function</subject><subject>Gastroenterology</subject><subject>Leg</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>NCT</subject><subject>NCT03681080</subject><subject>Neurology</subject><subject>Norepinephrine</subject><subject>Ophthalmology</subject><subject>Pilot projects</subject><subject>Plasma levels</subject><subject>Posture</subject><subject>Research Article</subject><subject>Tachycardia</subject><issn>0959-9851</issn><issn>1619-1560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9Uctu1DAUtRCITgs_wAJZYtMuAn7Ejs0GoREvUalIlLXlOE7GVWIH26k0_8BH45mU8liw8rXvOefe4wPAM4xeYoSaVwkjIniFCK0QkgxV6AHYYI5lhRlHD8GmPMpKCoZPwGlKNwhhJih-DE5oQzjmlG_Aj20YvMvu1sJ-8Sa74J0foPNwDikvUY8wxLwrtc7OwKzNbm907JyGae-7GCYL9RQKpXN9b6P1Gbah2x_o7qCWXkMN5xjSbM1xzOzGkGHRLqDzL1fXXz-HYb1ePAGPej0m-_TuPAPf3r-73n6sLq8-fNq-vaxMTXiuZE9Yi1rN5bHC3DQ9pk1rpKE1qVlNGBWs6wRuOyoa2tsWaa2laJEpxht6Bt6suvPSTrYzZeliVM3RTTruVdBO_d3xbqeGcKswqqlEVBSF8zuFGL4vNmU1uWTsOGpvw5IUEQTzGgt5gL74B3oTluiLv4JiFDFChSwosqJM-aoUbX-_DUbqkLZa01YlbXVMW6FCev6nj3vKr3gLgK6AVFp-sPH37P_I_gQfE7j3</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Maier, Andrea</creator><creator>Schopen, Lena</creator><creator>Thiel, Joana C.</creator><creator>Müller, Katharina</creator><creator>Fimm, Bruno</creator><creator>Schulz, Jörg B.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3427-4806</orcidid><orcidid>https://orcid.org/0000-0002-8903-0593</orcidid><orcidid>https://orcid.org/0000-0002-5818-9526</orcidid></search><sort><creationdate>20230801</creationdate><title>Cognitive functioning in postural orthostatic tachycardia syndrome among different body positions: a prospective pilot study (POTSKog study)</title><author>Maier, Andrea ; Schopen, Lena ; Thiel, Joana C. ; Müller, Katharina ; Fimm, Bruno ; Schulz, Jörg B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-9f25b0ba699f25b16c7f137bc9c34245425385dd81bd3873feb0aaa98b0c72673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cardiac arrhythmia</topic><topic>Cardiology</topic><topic>Cognitive ability</topic><topic>Diabetes</topic><topic>Endocrinology</topic><topic>Executive function</topic><topic>Gastroenterology</topic><topic>Leg</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>NCT</topic><topic>NCT03681080</topic><topic>Neurology</topic><topic>Norepinephrine</topic><topic>Ophthalmology</topic><topic>Pilot projects</topic><topic>Plasma levels</topic><topic>Posture</topic><topic>Research Article</topic><topic>Tachycardia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maier, Andrea</creatorcontrib><creatorcontrib>Schopen, Lena</creatorcontrib><creatorcontrib>Thiel, Joana C.</creatorcontrib><creatorcontrib>Müller, Katharina</creatorcontrib><creatorcontrib>Fimm, Bruno</creatorcontrib><creatorcontrib>Schulz, Jörg B.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical autonomic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maier, Andrea</au><au>Schopen, Lena</au><au>Thiel, Joana C.</au><au>Müller, Katharina</au><au>Fimm, Bruno</au><au>Schulz, Jörg B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognitive functioning in postural orthostatic tachycardia syndrome among different body positions: a prospective pilot study (POTSKog study)</atitle><jtitle>Clinical autonomic research</jtitle><stitle>Clin Auton Res</stitle><addtitle>Clin Auton Res</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>33</volume><issue>4</issue><spage>459</spage><epage>468</epage><pages>459-468</pages><issn>0959-9851</issn><eissn>1619-1560</eissn><abstract>Purpose Approximately 96% of patients with postural orthostatic tachycardia syndrome (PoTS) report cognitive complaints. We investigated whether cognitive function is impaired during sitting and active standing in 30 patients with PoTS compared with 30 healthy controls (HCs) and whether it will improve with the counter manoeuvre of leg crossing. Methods In this prospective pilot study, patients with PoTS were compared to HCs matched for age, sex, and educational level. Baseline data included norepinephrine plasma levels, autonomic testing and baseline cognitive function in a seated position [the Montreal Cognitive Assessment, the Leistungsprüfsystem (LPS) subtests 1 and 2, and the Test of Attentional Performance (TAP)]. Cognitive functioning was examined in a randomized order in supine, upright and upright legs crossed position. The primary outcomes were the cognitive test scores between HCs and patients with PoTS at baseline testing, and among the different body positions. Results Patients with PoTS had impaired attention (TAP median reaction time) in the seated position and impaired executive functioning (Stroop) while standing compared with HC. Stroop was influenced by position (supine versus upright versus upright legs crossed) only in the PoTS group. Leg crossing did not result in an improvement in executive function. In patients with PoTS, there was a negative correlation of Stroop with norepinephrine plasma levels while standing. Conclusion Compared with HCs, PoTS participants showed impaired cognitive attention and executive function in the upright position that did not improve in the legs crossed position. Data provide further evidence for orthostatic cognitive deterioration in patients with PoTS. Trial Registration Information The study was registered at ClinicalTrials.gov (NCT03681080).</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37261636</pmid><doi>10.1007/s10286-023-00950-0</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-3427-4806</orcidid><orcidid>https://orcid.org/0000-0002-8903-0593</orcidid><orcidid>https://orcid.org/0000-0002-5818-9526</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0959-9851
ispartof Clinical autonomic research, 2023-08, Vol.33 (4), p.459-468
issn 0959-9851
1619-1560
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10439038
source SpringerNature Journals
subjects Cardiac arrhythmia
Cardiology
Cognitive ability
Diabetes
Endocrinology
Executive function
Gastroenterology
Leg
Medicine
Medicine & Public Health
NCT
NCT03681080
Neurology
Norepinephrine
Ophthalmology
Pilot projects
Plasma levels
Posture
Research Article
Tachycardia
title Cognitive functioning in postural orthostatic tachycardia syndrome among different body positions: a prospective pilot study (POTSKog study)
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T11%3A22%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cognitive%20functioning%20in%20postural%20orthostatic%20tachycardia%20syndrome%20among%20different%20body%20positions:%20a%20prospective%20pilot%20study%20(POTSKog%20study)&rft.jtitle=Clinical%20autonomic%20research&rft.au=Maier,%20Andrea&rft.date=2023-08-01&rft.volume=33&rft.issue=4&rft.spage=459&rft.epage=468&rft.pages=459-468&rft.issn=0959-9851&rft.eissn=1619-1560&rft_id=info:doi/10.1007/s10286-023-00950-0&rft_dat=%3Cproquest_pubme%3E2853052389%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2853052389&rft_id=info:pmid/37261636&rfr_iscdi=true