The Gut-Heart Axis: Updated Review for The Roles of Microbiome in Cardiovascular Health
Cardiovascular diseases (CVDs), including coronary artery disease, stroke, heart failure, and hypertension, are the global leading causes of death, accounting for more than 30% of deaths worldwide. Although the risk factors of CVDs have been well understood and various treatment and preventive measu...
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Veröffentlicht in: | Korean circulation journal 2023-08, Vol.53 (8), p.499-518 |
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description | Cardiovascular diseases (CVDs), including coronary artery disease, stroke, heart failure, and hypertension, are the global leading causes of death, accounting for more than 30% of deaths worldwide. Although the risk factors of CVDs have been well understood and various treatment and preventive measures have been established, the mortality rate and the financial burden of CVDs are expected to grow exponentially over time due to the changes in lifestyles and increasing life expectancies of the present generation. Recent advancements in metagenomics and metabolomics analysis have identified gut microbiome and its associated metabolites as potential risk factors for CVDs, suggesting the possibility of developing more effective novel therapeutic strategies against CVD. In addition, increasing evidence has demonstrated the alterations in the ratio of
to
and the imbalance of microbial-dependent metabolites, including short-chain fatty acids and trimethylamine N-oxide, play a crucial role in the pathogenesis of CVD. However, the exact mechanism of action remains undefined to this day. In this review, we focus on the compositional changes in the gut microbiome and its related metabolites in various CVDs. Moreover, the potential treatment and preventive strategies targeting the gut microbiome and its metabolites are discussed. |
doi_str_mv | 10.4070/kcj.2023.0048 |
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to
and the imbalance of microbial-dependent metabolites, including short-chain fatty acids and trimethylamine N-oxide, play a crucial role in the pathogenesis of CVD. However, the exact mechanism of action remains undefined to this day. In this review, we focus on the compositional changes in the gut microbiome and its related metabolites in various CVDs. Moreover, the potential treatment and preventive strategies targeting the gut microbiome and its metabolites are discussed.</description><identifier>ISSN: 1738-5520</identifier><identifier>EISSN: 1738-5555</identifier><identifier>DOI: 10.4070/kcj.2023.0048</identifier><identifier>PMID: 37525495</identifier><language>eng</language><publisher>Korea (South): The Korean Society of Cardiology</publisher><subject>State of the Art Review</subject><ispartof>Korean circulation journal, 2023-08, Vol.53 (8), p.499-518</ispartof><rights>Copyright © 2023. The Korean Society of Cardiology.</rights><rights>Copyright © 2023. The Korean Society of Cardiology 2023 The Korean Society of Cardiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-a15f58b97ab2c4331130ef143c793a9864fd4fa18de8160ee77fb809546f66a03</citedby><cites>FETCH-LOGICAL-c388t-a15f58b97ab2c4331130ef143c793a9864fd4fa18de8160ee77fb809546f66a03</cites><orcidid>0000-0002-4423-5990 ; 0000-0003-0720-1449 ; 0009-0008-4603-7438 ; 0000-0003-0805-5439 ; 0000-0002-2747-6119 ; 0009-0007-3052-5042 ; 0000-0001-8009-9546</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435824/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435824/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,887,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37525495$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bui, Thi Van Anh</creatorcontrib><creatorcontrib>Hwangbo, Hyesoo</creatorcontrib><creatorcontrib>Lai, Yimin</creatorcontrib><creatorcontrib>Hong, Seok Beom</creatorcontrib><creatorcontrib>Choi, Yeon-Jik</creatorcontrib><creatorcontrib>Park, Hun-Jun</creatorcontrib><creatorcontrib>Ban, Kiwon</creatorcontrib><title>The Gut-Heart Axis: Updated Review for The Roles of Microbiome in Cardiovascular Health</title><title>Korean circulation journal</title><addtitle>Korean Circ J</addtitle><description>Cardiovascular diseases (CVDs), including coronary artery disease, stroke, heart failure, and hypertension, are the global leading causes of death, accounting for more than 30% of deaths worldwide. Although the risk factors of CVDs have been well understood and various treatment and preventive measures have been established, the mortality rate and the financial burden of CVDs are expected to grow exponentially over time due to the changes in lifestyles and increasing life expectancies of the present generation. Recent advancements in metagenomics and metabolomics analysis have identified gut microbiome and its associated metabolites as potential risk factors for CVDs, suggesting the possibility of developing more effective novel therapeutic strategies against CVD. In addition, increasing evidence has demonstrated the alterations in the ratio of
to
and the imbalance of microbial-dependent metabolites, including short-chain fatty acids and trimethylamine N-oxide, play a crucial role in the pathogenesis of CVD. However, the exact mechanism of action remains undefined to this day. In this review, we focus on the compositional changes in the gut microbiome and its related metabolites in various CVDs. Moreover, the potential treatment and preventive strategies targeting the gut microbiome and its metabolites are discussed.</description><subject>State of the Art Review</subject><issn>1738-5520</issn><issn>1738-5555</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpVkU1LAzEQhoMoVqtHr5Kjl63JJtlkvUgpfoEilBaPIbs7sdFtU5Pdqv_eLa1F5zID8_DOx4vQGSUDTiS5fC_fBilJ2YAQrvbQEZVMJaKL_V2dkh46jvGNkIzzND9EPSZFKngujtDLZAb4rm2SezChwcMvF6_wdFmZBio8hpWDT2x9wGts7GuI2Fv85MrgC-fngN0Cj0yonF-ZWLa1CbgTqpvZCTqwpo5wus19NL29mYzuk8fnu4fR8DEpmVJNYqiwQhW5NEVacsYoZQQs5ayUOTO5yrituDVUVaBoRgCktIUiueCZzTJDWB9db3SXbTGHqoRFE0ytl8HNTfjW3jj9v7NwM_3qV5oSzoRKeadwsVUI_qOF2Oi5iyXUtVmAb6NOFeeZzAWTHZps0O78GAPY3RxK9NoN3bmh127otRsdf_53uR39-372A7-ghaM</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Bui, Thi Van Anh</creator><creator>Hwangbo, Hyesoo</creator><creator>Lai, Yimin</creator><creator>Hong, Seok Beom</creator><creator>Choi, Yeon-Jik</creator><creator>Park, Hun-Jun</creator><creator>Ban, Kiwon</creator><general>The Korean Society of Cardiology</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4423-5990</orcidid><orcidid>https://orcid.org/0000-0003-0720-1449</orcidid><orcidid>https://orcid.org/0009-0008-4603-7438</orcidid><orcidid>https://orcid.org/0000-0003-0805-5439</orcidid><orcidid>https://orcid.org/0000-0002-2747-6119</orcidid><orcidid>https://orcid.org/0009-0007-3052-5042</orcidid><orcidid>https://orcid.org/0000-0001-8009-9546</orcidid></search><sort><creationdate>20230801</creationdate><title>The Gut-Heart Axis: Updated Review for The Roles of Microbiome in Cardiovascular Health</title><author>Bui, Thi Van Anh ; Hwangbo, Hyesoo ; Lai, Yimin ; Hong, Seok Beom ; Choi, Yeon-Jik ; Park, Hun-Jun ; Ban, Kiwon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-a15f58b97ab2c4331130ef143c793a9864fd4fa18de8160ee77fb809546f66a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>State of the Art Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bui, Thi Van Anh</creatorcontrib><creatorcontrib>Hwangbo, Hyesoo</creatorcontrib><creatorcontrib>Lai, Yimin</creatorcontrib><creatorcontrib>Hong, Seok Beom</creatorcontrib><creatorcontrib>Choi, Yeon-Jik</creatorcontrib><creatorcontrib>Park, Hun-Jun</creatorcontrib><creatorcontrib>Ban, Kiwon</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Korean circulation journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bui, Thi Van Anh</au><au>Hwangbo, Hyesoo</au><au>Lai, Yimin</au><au>Hong, Seok Beom</au><au>Choi, Yeon-Jik</au><au>Park, Hun-Jun</au><au>Ban, Kiwon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Gut-Heart Axis: Updated Review for The Roles of Microbiome in Cardiovascular Health</atitle><jtitle>Korean circulation journal</jtitle><addtitle>Korean Circ J</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>53</volume><issue>8</issue><spage>499</spage><epage>518</epage><pages>499-518</pages><issn>1738-5520</issn><eissn>1738-5555</eissn><abstract>Cardiovascular diseases (CVDs), including coronary artery disease, stroke, heart failure, and hypertension, are the global leading causes of death, accounting for more than 30% of deaths worldwide. Although the risk factors of CVDs have been well understood and various treatment and preventive measures have been established, the mortality rate and the financial burden of CVDs are expected to grow exponentially over time due to the changes in lifestyles and increasing life expectancies of the present generation. Recent advancements in metagenomics and metabolomics analysis have identified gut microbiome and its associated metabolites as potential risk factors for CVDs, suggesting the possibility of developing more effective novel therapeutic strategies against CVD. In addition, increasing evidence has demonstrated the alterations in the ratio of
to
and the imbalance of microbial-dependent metabolites, including short-chain fatty acids and trimethylamine N-oxide, play a crucial role in the pathogenesis of CVD. However, the exact mechanism of action remains undefined to this day. In this review, we focus on the compositional changes in the gut microbiome and its related metabolites in various CVDs. Moreover, the potential treatment and preventive strategies targeting the gut microbiome and its metabolites are discussed.</abstract><cop>Korea (South)</cop><pub>The Korean Society of Cardiology</pub><pmid>37525495</pmid><doi>10.4070/kcj.2023.0048</doi><tpages>20</tpages><orcidid>https://orcid.org/0000-0002-4423-5990</orcidid><orcidid>https://orcid.org/0000-0003-0720-1449</orcidid><orcidid>https://orcid.org/0009-0008-4603-7438</orcidid><orcidid>https://orcid.org/0000-0003-0805-5439</orcidid><orcidid>https://orcid.org/0000-0002-2747-6119</orcidid><orcidid>https://orcid.org/0009-0007-3052-5042</orcidid><orcidid>https://orcid.org/0000-0001-8009-9546</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | State of the Art Review |
title | The Gut-Heart Axis: Updated Review for The Roles of Microbiome in Cardiovascular Health |
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