PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice

HNF4α regulates various genes to maintain liver function. There have been reports linking HNF4α expression to the development of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis. In this study, liver-specific Hnf4a-deficient mice (Hnf4aΔHep mice) developed hepatosteatosis...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 2023-04, Vol.173 (5), p.393-411
Hauptverfasser:	Kasano-Camones, Carlos Ichiro, Takizawa, Masayuki, Ohshima, Noriyasu, Saito, Chinatsu, Iwasaki, Wakana, Nakagawa, Yuko, Fujitani, Yoshio, Yoshida, Ryo, Saito, Yoshifumi, Izumi, Takashi, Terawaki, Shin-Ichi, Sakaguchi, Masakiyo, Gonzalez, Frank J, Inoue, Yusuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Hepatocyte Nuclear Factor 4 - genetics Hepatocyte Nuclear Factor 4 - metabolism Lipid Metabolism Liver - metabolism Liver Cirrhosis - metabolism Mice Mice, Inbred C57BL Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - pathology PPAR alpha - genetics PPAR alpha - metabolism Regular Paper
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