Localized malignant mesothelioma, an unusual and poorly characterized neoplasm of serosal origin: best current evidence from the literature and the International Mesothelioma Panel
Localized malignant mesotheliomas (LMM) is an uncommon and poorly recognized neoplasm. Its pathologic diagnosis is often surprising in patients with serosal/subserosal based localized tumors that are clinically suspicious for metastatic lesions or primary sarcomas. Once a tumor is diagnosed as “meso...
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| Veröffentlicht in: | Modern pathology 2020-02, Vol.33 (2), p.281-296 |
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| creator | Marchevsky, Alberto M. Khoor, Andras Walts, Ann E. Nicholson, Andrew G. Zhang, Yu Zhi Roggli, Victor Carney, John Roden, Anja C. Tazelaar, Henry D. Larsen, Brandon T. LeStang, Nolwenn Chirieac, Lucian R. Klebe, Sonja Tsao, Ming-Sound De Perrot, Marc Pierre, Andrew Hwang, David M. Hung, Yin P. Mino-Kenudson, Mari Travis, William Sauter, Jennifer Beasley, Mary Beth Galateau-Sallé, Françoise |
| description | Localized malignant mesotheliomas (LMM) is an uncommon and poorly recognized neoplasm. Its pathologic diagnosis is often surprising in patients with serosal/subserosal based localized tumors that are clinically suspicious for metastatic lesions or primary sarcomas. Once a tumor is diagnosed as “mesothelioma”, LMM is often mistaken for diffuse malignant mesothelioma (DMM). Best currently available evidence about LMM was collected from the literature and cases diagnosed by members of the International Mesothelioma Panel (IMP). One hundred and one (101) LMM have been reported in the English literature. Patients had localized tumors with identical histopathologic features to DMM. Patients ranged in age from 6 to 82 years; 75% were men. Most (82%) of the tumors were intrathoracic. Others presented as intrahepatic, mesenteric, gastric, pancreatic, umbilical, splenic, and abdominal wall lesions. Tumors varied in size from 0.6 to 15 cm. Most patients underwent surgical resection and/or chemotherapy or radiation therapy. Median survival in a subset of patients was 29 months. Seventy two additional LMM from IMP institutions ranged in age from 28 to 95 years; 58.3% were men. Sixty tumors (83.3%) were intrathoracic, others presented in intraabdominal sites. Tumors varied in size from 1.2 to 19 cm. Median survival for 51 cases was 134 months. Best evidence was used to formulate guidelines for the diagnosis of LMM. It is important to distinguish LMM from DMM as their treatment and prognosis is different. A multidisciplinary approach is needed for the diagnosis of LMM as it shows identical histopathology and immunophenotype to DMM. |
| doi_str_mv | 10.1038/s41379-019-0352-3 |
| format | Article |
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Its pathologic diagnosis is often surprising in patients with serosal/subserosal based localized tumors that are clinically suspicious for metastatic lesions or primary sarcomas. Once a tumor is diagnosed as “mesothelioma”, LMM is often mistaken for diffuse malignant mesothelioma (DMM). Best currently available evidence about LMM was collected from the literature and cases diagnosed by members of the International Mesothelioma Panel (IMP). One hundred and one (101) LMM have been reported in the English literature. Patients had localized tumors with identical histopathologic features to DMM. Patients ranged in age from 6 to 82 years; 75% were men. Most (82%) of the tumors were intrathoracic. Others presented as intrahepatic, mesenteric, gastric, pancreatic, umbilical, splenic, and abdominal wall lesions. Tumors varied in size from 0.6 to 15 cm. Most patients underwent surgical resection and/or chemotherapy or radiation therapy. Median survival in a subset of patients was 29 months. Seventy two additional LMM from IMP institutions ranged in age from 28 to 95 years; 58.3% were men. Sixty tumors (83.3%) were intrathoracic, others presented in intraabdominal sites. Tumors varied in size from 1.2 to 19 cm. Median survival for 51 cases was 134 months. Best evidence was used to formulate guidelines for the diagnosis of LMM. It is important to distinguish LMM from DMM as their treatment and prognosis is different. A multidisciplinary approach is needed for the diagnosis of LMM as it shows identical histopathology and immunophenotype to DMM.</description><identifier>ISSN: 0893-3952</identifier><identifier>EISSN: 1530-0285</identifier><identifier>DOI: 10.1038/s41379-019-0352-3</identifier><identifier>PMID: 31485011</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>13/51 ; 692/308/409 ; 692/699/67/1059 ; Abdominal wall ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy ; Chemotherapy ; Child ; Diagnosis ; Diagnosis, Differential ; Evidence-Based Medicine ; Female ; Humans ; Laboratory Medicine ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Mesothelioma ; Mesothelioma, Malignant - diagnostic imaging ; Mesothelioma, Malignant - mortality ; Mesothelioma, Malignant - pathology ; Mesothelioma, Malignant - therapy ; Metastases ; Middle Aged ; Pancreas ; Pathology ; Pleural Neoplasms - diagnostic imaging ; Pleural Neoplasms - mortality ; Pleural Neoplasms - pathology ; Pleural Neoplasms - therapy ; Predictive Value of Tests ; Prognosis ; Radiation therapy ; Solitary Fibrous Tumor, Pleural - diagnostic imaging ; Solitary Fibrous Tumor, Pleural - mortality ; Solitary Fibrous Tumor, Pleural - pathology ; Solitary Fibrous Tumor, Pleural - therapy ; Spleen ; Survival ; Tumor Burden ; Tumors ; Young Adult</subject><ispartof>Modern pathology, 2020-02, Vol.33 (2), p.281-296</ispartof><rights>United States & Canadian Academy of Pathology 2019</rights><rights>2019© United States & Canadian Academy of Pathology 2019</rights><rights>United States & Canadian Academy of Pathology 2019.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-ac44715487dad5ed51ad321953793e42ed85177450714cb7ac83ae5cc44328a13</citedby><cites>FETCH-LOGICAL-c565t-ac44715487dad5ed51ad321953793e42ed85177450714cb7ac83ae5cc44328a13</cites><orcidid>0000-0002-8568-1591</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2475025838?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,27923,27924,64384,64386,64388,72240</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31485011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marchevsky, Alberto M.</creatorcontrib><creatorcontrib>Khoor, Andras</creatorcontrib><creatorcontrib>Walts, Ann E.</creatorcontrib><creatorcontrib>Nicholson, Andrew G.</creatorcontrib><creatorcontrib>Zhang, Yu Zhi</creatorcontrib><creatorcontrib>Roggli, Victor</creatorcontrib><creatorcontrib>Carney, John</creatorcontrib><creatorcontrib>Roden, Anja C.</creatorcontrib><creatorcontrib>Tazelaar, Henry D.</creatorcontrib><creatorcontrib>Larsen, Brandon T.</creatorcontrib><creatorcontrib>LeStang, Nolwenn</creatorcontrib><creatorcontrib>Chirieac, Lucian R.</creatorcontrib><creatorcontrib>Klebe, Sonja</creatorcontrib><creatorcontrib>Tsao, Ming-Sound</creatorcontrib><creatorcontrib>De Perrot, Marc</creatorcontrib><creatorcontrib>Pierre, Andrew</creatorcontrib><creatorcontrib>Hwang, David M.</creatorcontrib><creatorcontrib>Hung, Yin P.</creatorcontrib><creatorcontrib>Mino-Kenudson, Mari</creatorcontrib><creatorcontrib>Travis, William</creatorcontrib><creatorcontrib>Sauter, Jennifer</creatorcontrib><creatorcontrib>Beasley, Mary Beth</creatorcontrib><creatorcontrib>Galateau-Sallé, Françoise</creatorcontrib><title>Localized malignant mesothelioma, an unusual and poorly characterized neoplasm of serosal origin: best current evidence from the literature and the International Mesothelioma Panel</title><title>Modern pathology</title><addtitle>Mod Pathol</addtitle><addtitle>Mod Pathol</addtitle><description>Localized malignant mesotheliomas (LMM) is an uncommon and poorly recognized neoplasm. Its pathologic diagnosis is often surprising in patients with serosal/subserosal based localized tumors that are clinically suspicious for metastatic lesions or primary sarcomas. Once a tumor is diagnosed as “mesothelioma”, LMM is often mistaken for diffuse malignant mesothelioma (DMM). Best currently available evidence about LMM was collected from the literature and cases diagnosed by members of the International Mesothelioma Panel (IMP). One hundred and one (101) LMM have been reported in the English literature. Patients had localized tumors with identical histopathologic features to DMM. Patients ranged in age from 6 to 82 years; 75% were men. Most (82%) of the tumors were intrathoracic. Others presented as intrahepatic, mesenteric, gastric, pancreatic, umbilical, splenic, and abdominal wall lesions. Tumors varied in size from 0.6 to 15 cm. Most patients underwent surgical resection and/or chemotherapy or radiation therapy. Median survival in a subset of patients was 29 months. Seventy two additional LMM from IMP institutions ranged in age from 28 to 95 years; 58.3% were men. Sixty tumors (83.3%) were intrathoracic, others presented in intraabdominal sites. Tumors varied in size from 1.2 to 19 cm. Median survival for 51 cases was 134 months. Best evidence was used to formulate guidelines for the diagnosis of LMM. It is important to distinguish LMM from DMM as their treatment and prognosis is different. A multidisciplinary approach is needed for the diagnosis of LMM as it shows identical histopathology and immunophenotype to DMM.</description><subject>13/51</subject><subject>692/308/409</subject><subject>692/699/67/1059</subject><subject>Abdominal wall</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biopsy</subject><subject>Chemotherapy</subject><subject>Child</subject><subject>Diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Evidence-Based Medicine</subject><subject>Female</subject><subject>Humans</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mesothelioma</subject><subject>Mesothelioma, Malignant - diagnostic imaging</subject><subject>Mesothelioma, Malignant - mortality</subject><subject>Mesothelioma, Malignant - pathology</subject><subject>Mesothelioma, Malignant - therapy</subject><subject>Metastases</subject><subject>Middle Aged</subject><subject>Pancreas</subject><subject>Pathology</subject><subject>Pleural Neoplasms - diagnostic imaging</subject><subject>Pleural Neoplasms - mortality</subject><subject>Pleural Neoplasms - pathology</subject><subject>Pleural Neoplasms - therapy</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Radiation therapy</subject><subject>Solitary Fibrous Tumor, Pleural - diagnostic imaging</subject><subject>Solitary Fibrous Tumor, Pleural - mortality</subject><subject>Solitary Fibrous Tumor, Pleural - pathology</subject><subject>Solitary Fibrous Tumor, Pleural - therapy</subject><subject>Spleen</subject><subject>Survival</subject><subject>Tumor Burden</subject><subject>Tumors</subject><subject>Young 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neoplasm of serosal origin: best current evidence from the literature and the International Mesothelioma Panel</atitle><jtitle>Modern pathology</jtitle><stitle>Mod Pathol</stitle><addtitle>Mod Pathol</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>33</volume><issue>2</issue><spage>281</spage><epage>296</epage><pages>281-296</pages><issn>0893-3952</issn><eissn>1530-0285</eissn><abstract>Localized malignant mesotheliomas (LMM) is an uncommon and poorly recognized neoplasm. Its pathologic diagnosis is often surprising in patients with serosal/subserosal based localized tumors that are clinically suspicious for metastatic lesions or primary sarcomas. Once a tumor is diagnosed as “mesothelioma”, LMM is often mistaken for diffuse malignant mesothelioma (DMM). Best currently available evidence about LMM was collected from the literature and cases diagnosed by members of the International Mesothelioma Panel (IMP). One hundred and one (101) LMM have been reported in the English literature. Patients had localized tumors with identical histopathologic features to DMM. Patients ranged in age from 6 to 82 years; 75% were men. Most (82%) of the tumors were intrathoracic. Others presented as intrahepatic, mesenteric, gastric, pancreatic, umbilical, splenic, and abdominal wall lesions. Tumors varied in size from 0.6 to 15 cm. Most patients underwent surgical resection and/or chemotherapy or radiation therapy. Median survival in a subset of patients was 29 months. Seventy two additional LMM from IMP institutions ranged in age from 28 to 95 years; 58.3% were men. Sixty tumors (83.3%) were intrathoracic, others presented in intraabdominal sites. Tumors varied in size from 1.2 to 19 cm. Median survival for 51 cases was 134 months. Best evidence was used to formulate guidelines for the diagnosis of LMM. It is important to distinguish LMM from DMM as their treatment and prognosis is different. A multidisciplinary approach is needed for the diagnosis of LMM as it shows identical histopathology and immunophenotype to DMM.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>31485011</pmid><doi>10.1038/s41379-019-0352-3</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-8568-1591</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0893-3952 |
| ispartof | Modern pathology, 2020-02, Vol.33 (2), p.281-296 |
| issn | 0893-3952 1530-0285 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10428660 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; Alma/SFX Local Collection |
| subjects | 13/51 692/308/409 692/699/67/1059 Abdominal wall Adolescent Adult Aged Aged, 80 and over Biopsy Chemotherapy Child Diagnosis Diagnosis, Differential Evidence-Based Medicine Female Humans Laboratory Medicine Male Medical prognosis Medicine Medicine & Public Health Mesothelioma Mesothelioma, Malignant - diagnostic imaging Mesothelioma, Malignant - mortality Mesothelioma, Malignant - pathology Mesothelioma, Malignant - therapy Metastases Middle Aged Pancreas Pathology Pleural Neoplasms - diagnostic imaging Pleural Neoplasms - mortality Pleural Neoplasms - pathology Pleural Neoplasms - therapy Predictive Value of Tests Prognosis Radiation therapy Solitary Fibrous Tumor, Pleural - diagnostic imaging Solitary Fibrous Tumor, Pleural - mortality Solitary Fibrous Tumor, Pleural - pathology Solitary Fibrous Tumor, Pleural - therapy Spleen Survival Tumor Burden Tumors Young Adult |
| title | Localized malignant mesothelioma, an unusual and poorly characterized neoplasm of serosal origin: best current evidence from the literature and the International Mesothelioma Panel |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T10%3A47%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Localized%20malignant%20mesothelioma,%20an%20unusual%20and%20poorly%20characterized%20neoplasm%20of%20serosal%20origin:%20best%20current%20evidence%20from%20the%20literature%20and%20the%20International%20Mesothelioma%20Panel&rft.jtitle=Modern%20pathology&rft.au=Marchevsky,%20Alberto%20M.&rft.date=2020-02-01&rft.volume=33&rft.issue=2&rft.spage=281&rft.epage=296&rft.pages=281-296&rft.issn=0893-3952&rft.eissn=1530-0285&rft_id=info:doi/10.1038/s41379-019-0352-3&rft_dat=%3Cproquest_pubme%3E2349174917%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2349174917&rft_id=info:pmid/31485011&rfr_iscdi=true |